2017 – 2021 - Leukemia Gene Discovery by data sharing, mining and collaboration - LEGEND (CA16223) – (COST, 2017-2021), učesnik
2013 – 2016 - Strengthening the Research Potential of IMGGE through Reinforcement of Biomedical Science of Rare Diseases in Serbia – en route for innovation, SERBORDISinn (EU-FP7-REGPOT, 316088, 2013-2016), rukovodilac WP2c

2011 – 2019 - „Retke bolesti: molekularna patofiziologija, dijagnostički i terapijski modaliteti i socijalni, etički i pravni aspekti“ (MPNTR, III 41004, 2011-2019), rukovodilac projektnih zadataka u okviru potprojekata 3 i 4: „Dijagnostički i prognostički molekularni markeri kod limfoproliferativnih oboljenja“ i „Molekularnogenetički i imunofenotipski markeri klonskog preobražaja matičnih ćelija hematopoeze“

2006 – 2010 - Strukturalni elementi genoma u modulaciji fenotipa (MNTRS, 143051, 2006-2010), učesnik

2006 – 2009 - Health Improvement in Serbia through Reinforcement of Biomedical Science and Technology -HISERBS (EU FP6 SSA INCO-026357, 2006-2009), učesnik

2003 – 2005 - Mutirani gen u kontekstu drugih gena (MNZŽS, 1417, 2002-2005), učesnik

2000 - 2003 - volonter u Laboratoriji za imunologiju, Zavod za transfuziju Srbije, Beograd
1999 – 2000 - istraživač u Laboratoriji za antioksidativne enzime, Institut Vinča, Beograd 

OSTALE AKTIVNOSTI

2012-2021 - predavač na doktorskim studijama na Biološkom fakultetu, UB, u okviru studijskog programa molekularna biologija (predmeti „Molekularna genetika bolesti čoveka“, „Molekularna hematologija“  i „Personalizovana medicina i farmakogenetika“)  

 2019 - član Naučnog veća IMGGI, UB

OBLAST NAUČNOG INTERESOVANJA

Istraživanja u oblasti genetike kancera sa fokusom na hematološke malignitete. Detekcija genetičkih promena koji leže u osnovi procesa kancerogeneze.  Molekularni markeri značajni za dijagnozu i terapiju kancera.

ODABRANI NAUČNI RADOVI

Celokupna lista radova je dostupna na linku https://scholar.google.com/citations?user=k921DjoAAAAJ&hl=sr

Marjanovic I, Karan-Djurasevic T, Kostic T, Virijevic M, Vukovic NS, Pavlovic S, Tosic N. Prognostic significance of combined BAALC and MN1 gene expression level in acute myeloid leukemia with normal karyotype. Int J Lab Hematol. 2021 Jun;43(3):433-440. doi: 10.1111/ijlh.13405

Vesovic N, Tosic N, Karan Djurasevic T, Andric Z, Zdravkovic D, Pavlovic S, Jovanovic D. Expression pattern of circulating long non-coding RNA GAS5 as a novel biomarker in non-small cell lung cancer patients. Arch Med Sci. 2020 https://doi.org/10.5114/aoms.2020.98815          

Mitrovic M, Kostic T, Virijevic M, Karan-Djurasevic T, Suvajdzic Vukovic N, Pavlovic S, Tosic N. The influence of Wilms' tumor 1 gene expression level on prognosis and risk stratification of acute promyelocytic leukemia patients. Int J Lab Hematol, 2020;42(1):82-87. doi: 10.1111/ijlh.13144

Tosic N, Petrovic I, Grujicic NK, Davidovic S, Virijevic M, Vukovic NS, Pavlovic S, Stevanovic M. Prognostic significance of SOX2, SOX3, SOX11, SOX14 and SOX18 gene expression in adult de novo acute myeloid leukemia. Leuk Res. 2018 Apr;67:32-38. doi:10.1016/j.leukres.2018.02.001

Todorovic Balint M, Jelicic J, Mihaljevic B, Kostic J, Stanic B, Balint B, Pejanovic N, Lucic B, Tosic N, Marjanovic I, Stojiljkovic M, Karan-Djurasevic T, Perisic O, Rakocevic G, Popovic M, Raicevic S, Bila J, Antic D, Andjelic B, Pavlovic S. Gene Mutation Profiles in Primary Diffuse Large B Cell Lymphoma of Central Nervous System: Next Generation Sequencing Analyses. Int J Mol Sci. 2016 May 6;17(5):683. doi: 10.3390/ijms17050683

Marjanovic I, Kostic J, Stanic B, Pejanovic N, Lucic B, Karan-Djurasevic T, Janic D, Dokmanovic L, Jankovic S, Vukovic NS, Tomin D, Perisic O, Rakocevic G, Popovic M, Pavlovic S, Tosic N. Parallel targeted next generation sequencing of childhood and adult acute myeloid leukemia patients reveals uniform genomic profile of the disease. Tumour Biol. 2016 Oct;37(10):13391-13401. doi: 10.1007/s13277-016-5142-7

Hackl H, Steinleitner K, Lind K, Hofer S, Tosic N, Pavlovic S, Suvajdzic N, Sill H, Wieser R. A gene expression profile associated with relapse of cytogenetically normal acute myeloid leukemia is enriched for leukemia stem cell genes. Leuk Lymphoma. 2015;56(4):1126-1128. doi: 10.3109/10428194.2014.944523

Puda A, Milosevic JD, Berg T, Klampfl T, Harutyunyan AS, Gisslinger B, Rumi E, Pietra D, Malcovati L, Elena C, Doubek M, Steurer M, Tosic N, Pavlovic S, Guglielmelli P, Pieri L, Vannucchi AM, Gisslinger H, Cazzola M, Kralovics R. Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies. Am J Hematol, 2012;87(3):245-250. doi: 10.1002/ajh.22257

Milosevic JD, Puda A, Malcovati L, Berg T, Hofbauer M, Stukalov A, Klampfl T, Harutyunyan AS, Gisslinger H, Gisslinger B, Burjanivova T, Rumi E, Pietra D, Elena C, Vannucchi AM, Doubek M, Dvorakova D, Robesova B, Wieser R, Koller E, Suvajdzic N, Tomin D, Tosic N, Colinge J, Racil Z, Steurer M, Pavlovic S, Cazzola M, Kralovics R. Clinical significance of genetic aberrations in secondary acute myeloid leukemia. Am J Hematol. 2012;87(11):1010-1016. doi: 10.1002/ajh.23309

Thomadaki H, Floros KV, Pavlovic S, Tosic N, Gourgiotis D, Colovic M, Scorilas A. Overexpression of the novel member of the BCL2 gene family, BCL2L12, is associated with the disease outcome in patients with acute myeloid leukemia. Clin Biochem. 2012;45(16-17):1362-1367. doi: 10.1016/j.clinbiochem.2012.06.012

Krstovski N, Tosic N, Janic D, Dokmanovic L, Kuzmanovic M, Spasovski V, Pavlovic S. Incidence of FLT3 and nucleophosmin gene mutations in childhood acute myeloid leukemia: Serbian experience and the review of the literature. Med Oncol. 2010 Sep;27(3):640-5. doi: 10.1007/s12032-009-9261-5

Lazić J, Tošić N, Dokmanović L, Krstovski N, Rodić P, Pavlović S, Janić D. Clinical features of the most common fusion genes in childhood acute lymphoblastic leukemia. Med Oncol. 2010;27(2):449-453. doi: 10.1007/s12032-009-9232-x

 Tošić N, Stojiljković M, Čolović N, Čolović M, Pavlović S. Acute myeloid leukemia with NUP98-HOXC13 fusion and FLT3-ITD mutation: case report and review of the literature. Cancer Genet Cytogenet. 2009;193(2):98-103. doi: 10.1016/j.cancergencyto.2009.03.007

Čolović N, Tošić N, Aveić S, Djurić M, Milić N, Bumbaširević V, Čolović M, Pavlović S. Importance of early detection and follow-up of FLT3 mutations in patients with acute myeloid leukemia. Ann Hematol. 2007;86(10):741-7. doi: 10.1007/s00277-007-0325-3

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