Human Molecular Genetics
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Research of Group for Human Molecular Genetics is dedicated to in vitro disease modeling. It has modern equipment and highly competent collaborators for research in human molecular genetics.
The main research topics of the Group are:
Modeling brain diseases - We study the molecular mechanisms underlying neurodevelopmental and neurodegenerative diseases. To study molecular mechanisms, we mastered the reprogramming of somatic cells into pluripotent stem cells, the formation of brain organoids, RNA sequencing, and whole genome and exome sequencing. Also, we are studying the effects of selected genes and microRNA expression modulations on the malignant potential of glioblastoma cells.
Neural differentiation -Within this research area, we analyze the roles of SOX genes and microRNAs in the astrocytes' reactivation. We are also studying the effects of energy drink consumption, as well as alcohol in combination with energy drinks, on the morphology and function of neural progenitors, neurons, and astrocytes. Part of the research focuses on studying the role of SOX genes and microRNAs and their potential interactions in diseases associated with brain ischemia.
Modeling of malignant diseases - To study the malignant phenotype of different types of tumors (osteosarcoma, pancreatic, and breast carcinoma) and the role of the tumor microenvironment, we develop 3D-model systems and co-cultures. Also, we study the anti-tumor potential of natural and synthetic compounds and elucidate their mechanism of action. In our research, we apply in vitro assays on many permanent cell lines originating from different types of tumors or normal tissues and in vivo assays using zebrafish as a model.
Group for Human Molecular Genetics offers:
Analysis of the DNA fragmentation level of spermatozoa as an addition to existing protocols in the treatments of male sterility.
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Danijela Drakulic, Full Research Professor
E-mail: danijela.drakulic@imgge.bg.ac.rs
Tel: +381 65 3976212
Vojvode Stepe 444a, 11042 Belgrade 152, Serbia -
FULL RESEARCH PROFESSOR
ASSOCIATE RESEARCH PROFESSOR
- Marija Mojsin
- Nataša Kovačević Grujičić
- Andrijana Lazić
- Danijela Drakulić
- Isidora Petrović
- Danijela Stanisavljević Ninković
ASSISTANT RESEARCH PROFESSOR
RESEARCH ASSISTANT
JUNIOR RESEARCHERS
IMGGE work program for 2024 - Ministry of Science, Technological Development and Innovation of the Republic of Serbia, 451-03-66/2024-03/200042, 2024
Strengthening regional stem cells based research for advancement of multi modal innovative strategy for modelling neurodevelopmental disorders (STREAMLINE) (2022-2025)
