Novel genetic markers of therapy resistance in rectal cancer
Whole exome sequencing was used to identify genetic variants linked to the response to preoperative chemoradiotherapy in locally advanced rectal cancer. Non-responders exhibited mutations in genes related to cell cycle regulation, adhesion, and migration, while good responders had mutations in genes associated with extracellular matrix remodeling and immune function. Six variants in transmembrane transporter genes were validated in a larger cohort, with two emerging as promising biomarkers of therapy resistance.
This research was carried out in collaboration with colleagues from the University Clinical Center of Serbia and the Faculty of Medicine, University of Belgrade.