Valentina Djordjević

Associate Research Professor
Laboratory for Molecular Biology (LMB)

Institute of molecular genetics and genetic engineering (IMGGE),
University of Belgrade

Vojvode Stepe 444a, 11042 Belgrade 152, Serbia
Mobile:      +381 65  3976658        
Phone:      +381 11 3976658
Fax:          +381 11 397 58 08
E-mail: valentina@imgge.bg.ac.rs

EDUCATION

2010 - PhD in Biology, Faculty of Biology (FB), UB
(“Analysis of human prothrombin gene 3' end influence on prothrombin gene expression and pathogenesis of thrombophilia”)
2002 - M.Sc. in Molecular Genetics and Genetic Engineering, FB, UB
2000 - B.Sc. in Molecular Biology and Physiology, FB, UB

RESEARCH EXPERIENCE

2015 - Senior Research Associate, LMB, IMGGE
2010 - 2015 - Research Associate LMB,IMGGE
2002 - 2010 - Research Assistant LMB, IMGGE
2000 - 2002 - Postgraduate fellow of national Ministry of Science LMB, IMGGE

CAREER HISTORY

2014 - Chair of Ethic Committe IMGGE, UB
2011 - Lecturer on Doctoral studies in Molecular Biology, FB, UB
2011 - Work package leader: project-Complex diseases as a model system for phenotype modulation- structural and functional analysis of molecular biomarkers, funded by MSTD of Republic of Serbia (173008); WP1- Cardiovascular phenotype

RESEARCH INTEREST

prothrombin,  functional analysis of 3'end prothrombin gene variants, regulation of prothrombin gene expression, prothrombin  in etiology of thrombophilia, cancer and  inflammation, prothrombin Belgrade mutation  (FII c.1787G>A),  screening for new thrombophilia markers, inherited thrombophilia.

SELECTED PUBLICATION

Clinical and biochemical characterization of the prothrombin Belgrade mutation in a large Serbian pedigree: new insights into the antithrombin resistance mechanism. Miljic P, Gvozdenov M, Takagi Y, Takagi A, Pruner I, Dragojevic M, Tomic B, Bodrozic J, Kojima T, Radojkovic D, Djordjevic V. J Thromb Haemost. 2017 Apr; 15(4): 670-677. [https://www.ncbi.nlm.nih.gov/pubmed/28075532]

Poor pregnancy outcome in women with homozygous type-II HBS antithrombin deficiency. Kovac M, Mitic G, Miljic P, Mikovic Z, Mandic V, Djordjevic V, Radojkovic D, Bereczky Z, Muszbek L. Thromb Res. 2014 Jun;133(6):1158-60.  [http://www.ncbi.nlm.nih.gov/pubmed/24702813]

Determination of transgene copy number in stably transfected mammalian cells by PCR-capillary electrophoresis assay. Pruner I, Djordjevic V, Gvozdenov M, Tomic B, Radojkovic D. Biochem Genet. 2014 Apr;52(3-4):159-65. [http://www.ncbi.nlm.nih.gov/pubmed/24292648]

A novel prothrombin mutation in two families with prominent thrombophilia--the first cases of antithrombin resistance in a Caucasian population. Djordjevic V, Kovac M, Miljic P, Murata M, Takagi A, Pruner I, Francuski D, Kojima T, Radojkovic D. J Thromb Haemost. 2013 Oct;11(10):1936-9. [http://www.ncbi.nlm.nih.gov/pubmed/23927452]

Prothrombotic genetic risk factors in stroke: a possible different role in pediatric and adult patients. Djordjevic V, Stankovic M, Brankovic-Sreckovic V, Rakicevic L, Damnjanovic T, Antonijevic N, Radojkovic D. Clin Appl Thromb Hemost. 2012 Nov;18(6):658-61. [http://www.ncbi.nlm.nih.gov/pubmed/22275392]

Are thrombophilia more multifactorial than we thought: report of mosaicism for FII G20210A and novel FII T20061C gene variants. Djordjevic V, Mitic G, Pruner I, Kovac M, Radojkovic D. J Thromb Haemost. 2012 Feb;10(2):301-3. [http://www.ncbi.nlm.nih.gov/pubmed/22141575]

+1040 C/T polymorphism in coding region of thrombin-activatable fibrinolysis inhibitor gene and the risk of idiopathic recurrent fetal loss. Pruner I, Djordjevic V, Miljic P, Kovac M, Antonijevic N, Rakicevic L, Radojkovic D. Blood Coagul Fibrinolysis. 2010 Oct;21(7):679-82.    [http://www.ncbi.nlm.nih.gov/pubmed/20729722]

Thrombophilia in women with pregnancy-associated complications: fetal loss and pregnancy-related venous thromboembolism. Kovac M, Mitic G, Mikovic Z, Djordjevic V, Savic O, Mandic V, Rakicevic LJ, Antonijevic N, Radojkovic D. Gynecol Obstet Invest. 2010;69(4):233-8. [http://www.ncbi.nlm.nih.gov/pubmed/20068329]

The use of D-dimer with new cutoff can be useful in diagnosis of venous thromboembolism in pregnancy. Kovac M, Mikovic Z, Rakicevic L, Srzentic S, Mandic V, Djordjevic V, Radojkovic D, Elezovic I. Eur J Obstet Gynecol Reprod Biol. 2010 Jan;148(1):27-30 [http://www.ncbi.nlm.nih.gov/pubmed/19804940]

Genetic risk factors for arterial ischemic stroke in children: a possible MTHFR and eNOS gene-gene interplay? Djordjevic V, Stankovic M, Brankovic-Sreckovic V, Rakicevic L, Radojkovic D. J Child Neurol. 2009 Jul;24(7):823-7. [http://www.ncbi.nlm.nih.gov/pubmed/19372095]

Procarboxypeptidase U (TAFI) contributes to the risk of thrombosis in patients with hereditary thrombophilia. Heylen E, Miljic P, Willemse J, Djordjevic V, Radojkovic D, Colovic M, Elezovic I, Hendriks D. Thromb Res. 2009 Sep;124(4):427-32. [http://www.ncbi.nlm.nih.gov/pubmed/19195685]

Arterial ischemic stroke in a child with beta-thalassemia trait and methylentetrahydrofolate reductase mutation. Brankovic-Sreckovic V, Milic Rasic V, Djordjevic V, Kuzmanovic M, Pavlovic S. J Child Neurol. 2007 Feb;22(2):208-10. [http://www.ncbi.nlm.nih.gov/pubmed/17621484]

Prevalence of factor V leiden, factor V cambridge, factor II G20210A and  methylenetetrahydrofolate reductase C677T mutations in healthy and thrombophilic Serbian populations. Djordjevic V, Rakicevic LJ, Mikovic D, Kovac M, Miljic P, Radojkovic D, Savic A. Acta Haematol. 2004;112(4):227-9. [http://www.ncbi.nlm.nih.gov/pubmed/15564739]

Severe central nervous system thrombotic events in hemoglobin Sabine patient. Pavlovic S, Kuzmanovic M, Urosevic J, Poznanic J, Zoranovic T, Djordjevic V, Rasovic N, Bunjevacki G, Cvorkov-Drazic M, Colovic M. Eur J Haematol. 2004 Jan;72(1):67-70. [http://www.ncbi.nlm.nih.gov/pubmed/14962267]

Combined severe factor XII deficiency and homozygous factor V Leiden mutation in a patient with venous thrombosis. Miljic P, Colovic M, Boskovic D, Rakicevic Lj, Djordjevic V. Thromb Res. 2002 May 15;106(4-5):265-7. [http://www.ncbi.nlm.nih.gov/pubmed/12297136]

Effect of steroid hormone deprivation on the expression of ecto-ATPase in distinct brain regions of female rats. Nedeljkovic N, Djordjevic V, Horvat A, Nikezic G, Kanazir DT. Physiol Res. 2000;49(4):419-26. [http://www.ncbi.nlm.nih.gov/pubmed/11072801]

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