Marija Švirtlih

Associate Research Professor
Laboratory for human molecular genetics

Institute of molecular genetics and genetic engineering (IMGGE)
University of Belgrade

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mob:    +381 65 3976212
Tel:      +381 11 3976212
Fax:     +381 11 397 58 08
E-mail: schwirtlich@imgge.bg.ac.rs

EDUCATION

2009 - PhD in Medical Sciences, Semmelweiss University, Budapest, Hungary. In 2012, nostrificated as PhD in Biological Sciences, Faculty of Biology (FB), UB (Molecular components and functionality of the GABA signaling during development: a study on two model systems)
1998 - B.Sc. in Molecular Biology and Physiology, FB, University of Belgrade

RESEARCH EXPERIENCE

2018 - Associate Research Professor, Institute of molecular genetics and genetic engineering (IMGGE), University of Belgrade
2012 - Assistant Research Professor, Institute of molecular genetics and genetic engineering (IMGGE), University of Belgrade

CAREER HISTORY

2012 - esearch Associate, Laboratory for human molecular genetics Institute of molecular genetics and genetic engineering (IMGGE) University of Belgrade
2001 - 2010 - Research Fellow, Laboratory of Molecular Biology and Genetics, Institute of Experimental Medicine Hungarian Academy of Sciences, Budapest, Hungary
1998 - 2001 - Research Trainee, Department of Neurobiology, Institute for Biological Research “Sinisa Stankovic”, Belgrade, Serbia 

RESEARCH INTEREST

Studying the role of SOXB1 and SOXB2 members of SOX family of transcription factors in the cell fate decision of pluripotent stem cells and neural progenitors during development of nervous system

Studying the role of SOXB1 members of SOX family of transcription factors in acquisition of malignant phenotype

Studying the role of GABA signaling in acquisition of neuronal and malignant phenotype

SELECTED PUBLICATIONS

  1. Todorović N., Mićić B., Schwirtlich M., Stevanović M., Filipović D. Subregion-specific Protective Effects of Fluoxetine and Clozapine on Parvalbumin Expression in Medial Prefrontal Cortex of Chronically Isolated Rats. Neuroscience. 2019 Jan 1;396:24-35. doi: 10.1016/j.neuroscience.2018.11.008. https://www.ncbi.nlm.nih.gov/pubmed/30448452
  2. Zaletel I., Schwirtlich M., Perović M., Jovanović M., Stevanović M., Kanazir S., Puškaš N. Early Impairments of Hippocampal Neurogenesis in 5xFAD Mouse Model of Alzheimer's Disease Are Associated with Altered Expression of SOXB Transcription Factors. J Alzheimers Dis. 2018, 65(3):963-976. https://www.ncbi.nlm.nih.gov/pubmed/30103323
  3. Topalovic V., Krstic A., Schwirtlich M., Dolfini D., Mantovani R., Stevanovic M., Mojsin M. (2017). Epigenetic regulation of human SOX3 gene expression during early phases of neural differentiation of NT2/D1 cells. PLOS ONE.12(9):e0184099. https://www.ncbi.nlm.nih.gov/pubmed/28886103
  4. Stanisavljevic D., Petrovic I., Vukovic V., Schwirtlich M., Gredic M., Stevanovic M., Popovic J. (2017). SOX14 activates the p53 signaling pathway and induces apoptosis in a cervical carcinoma cell line. PLOS ONE. 12(9):e0184686. https://www.ncbi.nlm.nih.gov/pubmed/28926586
  5. Petrovic I., Milivojevic M., Popovic J., Schwirtlich M., Rankovic B., Stevanovic M. (2015). SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines. PLOS ONE 10(11): e0143591. https://www.ncbi.nlm.nih.gov/pubmed/26588701
  6. Mojsin M., Topalovic V., Vicentic JM., Schwirtlich M., Stanisavljevic D., Drakulic D., Stevanovic M. (2015). Crosstalk between SOXB1 proteins and WNT/β-catenin signaling in NT2/D1 cells. Histochem Cell Biol. 144(5): 429-41. https://www.ncbi.nlm.nih.gov/pubmed/26239426
  7. Drakulic D, Vicentic JM, Schwirtlich M, Tosic J, Krstic A, Klajn A, Stevanovic M. (2015). The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1. An Acad Bras Cienc. 87(1):389-404. https://www.ncbi.nlm.nih.gov/pubmed/25761220
  8. Vastagh C., Schwirtlich M., Kwakowsky A., Erdélyi F., Margolis FL., Yanagawa Y., Katarova Z., Szabó G. (2014). The spatiotemporal segregation of GAD forms defines distinct GABA signaling functions in the developing mouse olfactory system and provides novel insights into the origin and migration of GnRH neurons. Dev Neurobiol. 75(3):249-70. https://www.ncbi.nlm.nih.gov/pubmed/25125027
  9. Popovic J., Stanisavljevic D., Schwirtlich M., Klajn A., Marjanovic J., Stevanovic M. (2014). Expression analysis of SOX14 during retinoic acid induced neural differentiation of embryonal carcinoma cells and assessment of the effect of its ectopic expression on SOXB members in HeLa cells. PLOS ONE 9(3):e91852. https://www.ncbi.nlm.nih.gov/pubmed/24637840
  10. Schwirtlich M., Kwakowsky A.,  Emri  Zs., Antal K., Lacza Zs., Cselenyák A., Katarova, Z., Szabó, G. (2011) GABAergic signaling in primary lens epithelial and lentoid cells and its involvement in intracellular Ca2+ modulation. Cell Calcium 50(4):381-92. https://www.ncbi.nlm.nih.gov/pubmed/21820173
  11. Schwirtlich M., Emri Zs., Antal K., Máté Z., Katarova Z., Szabó G. (2010) GABAA and GABAB receptors of distinct properties affect oppositely the proliferation of mouse embryonic stem cells through synergistic elevation of intracellular Ca2+. FASEB J. 24(4):1218-28. https://www.ncbi.nlm.nih.gov/pubmed/19959723

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