Jelena Kusic-Tisma

Assistant Research Professor
Laboratory for Molecular Biology (LMB)

Institute of molecular genetics and genetic engineering (IMGGE),
University of Belgrade

Vojvode Stepe 444a, 11042 Belgrade 152, Serbia
Phone: +381 11 397 66 58
Fax:    +381 11 397 58 08


2005 - PhD in Molecular Genetics and Genetic Engineering, Faculty of Biology, University of Belgrade
1999 - M.Sc. in Molecular Genetics and Genetic Engineering, Faculty of Biology, University of Belgrade
1995 - B.Sc. in Biology, Faculty of Biology, University of Belgrade


2005 - Research Associate LMB, IMGGE
1996 - 2005 - Research Assistant LMB, IMGGE
1995 - 1996 - Research TraineeLMB, IMGGE


2007 - Lecturer on Faculty of Biology


My research interest is in the genotype-phenotype relation of Hypertrophic Cardiomyopathy (HCM) and family screening in HCM. Currently, I’m analyzing involvement of the mutations in CARP1 protein in the etiology of HCM using FRAP and FRET techniques.


  1. Novkovic M, Matic D, Kusic-Tisma J, Antonijevic N, Radojkovic D, Rakicevic L (2018) Analysis of the CYP2C19 genotype associated with bleeding in Serbian STEMI patients who have undergone primary PCI and treatment with clopidogrel. Eur J Clin Pharmacol 74 (4): 443-451 DOI 10.1007/s00228-017-2401-5
  2. Backovic D, Ignjatovic S, Rakicevic L, Novkovic M, Kusic-Tisma J, Radojkovic D, Strugarevic E, Calija B, Radak D, Kovac M (2016) Clopidogrel High On-Treatment Platelet Reactivity in Patients with Carotid Artery Stenosis Undergoing Endarterectomy. A Pilot Study. Curr Vasc Pharmacol 14 (6): 563-569
  3. Bačković D, Ignjatović S , Rakićević L, Kusić-Tišma J, Radojković D, Čalija B, Strugarević E, Radak D, Kovač M. (2015) Influence of CYP2C19*2 gene variant on therapeutic response during clopidogrel treatment in patients with artery stenosis. J Med Biochem 34: 1–8, 2015; DOI: 10.1515/jomb-2015-0009.
  4. Tomic B, Kusic-Tisma J. (2015) HsOrc4-Dependent Dna Remodeling of the ori-β Dhfr Replicator. Cell Mol Biol Lett. 20(4):549-61. doi: 10.1515/cmble-2015-0032.
  5. Kovac MK, Rakicevic LB, Kusic-Tisma J, Radojkovic DP. (2013). Pharmacogenetic tests could be helpful in predicting of VKA maintenance dose in elderly patients at treatment initiation. J Thromb Thrombolysis. 35(1): 90-94
  6. Rakicevic LB, Kusic-Tisma J, Kovac MK, Backovic DT, Radojkovic DP. (2013) Rationalized DNA sequencing-based protocol for genotyping patients receiving coumarin therapy. Scand J Clin Lab Invest.; 73(6): 523-527.
  7. Kusic-Tisma Jelena and Stefanovic Dragana (2011). Replication Origin Selection and Pre-Replication Complex Assembly, DNA Replication-Current Advances, Dr Herve Seligmann (Ed.), ISBN: 978-953-307-593-8, InTech, DOI: 10.5772/21485.
  8. Divac A, Tomic B, Kusic J. The role of ATP in human ORC4 protein function. J Serb Chem Soc (2010) 75(3):317-322
  9. Кusic, J., Tomic, B., Divac, A., & Kojic, S. (2010). Human initiation protein Orc4 prefers triple stranded DNA. Molecular Biology Reports, 37(5), 2317-2322.
  10. Stankovic M, Nikolic A, Divac A, Tomovic A, Petrovic-Stanojevic N, Andjelic, M, Dopudja-Pantic V, Surlan M, Vujicic I, Ponomarev D, Mitic-Milikic M, Kusic J, Radojkovic, D. (2008). The CFTR M470V gene variant as a potential modifier of COPD severity: Study of serbian population. Genetic Testing, 12(3), 357-362
  11. Stefanovic D, Kusic J, Divac A, Tomic B. Formation of noncanonical DNA structures mediated by human ORC4, a protein component of the origin recognition complex. Biochemistry (2008) 47:8760-8767 PubMed
  12. Dinic J, Kusic J, Nikolic A, Divac A, Ristanovic M. (2006) Radojkovic D Analysis of Y chromosome microdeletions and CFTR gene mutations as genetic markers of infertility in Serbian men. Vojnosanit Pregl. 64(4):253-6.
  13. Kusic J, Kojic S, Divac A, Stefanovic D. (2005). Noncanonical DNA elements in the lamin B2 origin of DNA replication. Journal of Biological Chemistry, 280(11), 9848-9854. PubMed
  14. Nikolic A, Divac A, Kusic J, Savic A. (2001) Frequency of the CFTR 2694T/G polymorphism and its association with CFTR-related monosymptomatic disorders Balkan J Med Genet; 4(1&2): 43-46
  15. Radojkovic D, Kusic J. (2000). Silver staining of denaturing gradient gel electrophoresis gels. Clinical Chemistry, 46(6), 883-884. PubMed
  16. Dork T … Kusic J, Radojkovic D … et al. (2000) Characterization of a novel 21-kb deletion, CFTRdele2,3(21 kb), in the CFTR gene: a cystic fibrosis mutation of Slavic origin common in Central and East Europe. Hum Genet 106(3): 259-268
  17. Kusic J, Radojkovic D, Cuppens H, Jaspers M, Tomic J, Savic A. (1999). Identification of a novel mutation (525del T) in exon 4 of the CFTR gene in a patient with cystic fibrosis. Human Mutation, 14(4), 357. PubMed

Edited books:

DNA Replication and Related Cellular Processes, edited by Jelena Kusic-Tisma, ISBN 978-953-307-775-8, Publisher: InTech, 2011. DOI: 10.5772/818

Fundamental Aspects of DNA Replication, edited by Jelena Kusic-Tisma, ISBN 978-953-307-259-3, Publisher: InTech, 2011. DOI: 10.5772/766

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