Advanced functionalized biomaterial for the treatment of chronic wound infections

Technology transfer program, Innovation Fund of Serbia, TTP 1137, 2022-2023
Principal Investigator: Dr Lidija Djokic, IMGGE
Participant from IMGGE: Dr Lidija Senerovic

Chronic, non-healing wounds represent a huge socioeconomic burden. The prevalence of chronic wounds is estimated at 2.2 per 1000 population while total Medicare spending for wounds in the US only ranges from 28.1 to 96.8 billion dollars. Wound chronicity was linked to bacterial biofilms that cause persistent infections resistant to standard antibiotic therapy. Promising therapeutic strategies against biofilm formation and for biofilm dispersion are bacterial enzymes

The Project's main objective is to develop advanced bioactive functionalized wound dressing, based on bacterial enzyme and native or modified nanocellulose, that will:

• prevent infections in wounds, and
• enable proper therapy of infected chronic wounds.