NEURAD - Testing neurogenic potential of induced pluripotent stem cells derived from alzheimer’s disease patients

Serbian Science and Diaspora Collaboration Program: Knowledge Exchange Vouchers, Science Fund of the Republic of Serbia, 6436225, 2020-2021
Principal Investigator: Dr Marija Svirtlih, IMGGE
Participant from IMGGE: Dr Isidora Petrovic

Deregulated hippocampal neurogenesis occurs at the very early stages of Alzheimer’s disease (AD) and impairs neuronal repair mechanisms and possibly cognitive function in patients. We will characterize and compare neuronal stem/progenitor cells derived from induced pluripotent stem cells (iPSc) of AD patients and healthy individuals. This model system will help to uncover new molecular drivers involved in neuroplasticity and might lead to improvement of diagnostic and therapeutic strategies.