The Eco-Biotechnology and Drug Development Group published in the “International Journal of Biological Macromolecules“ a paper entitled „New model compounds for the efficient colorimetric screening of medium chain length polyhydroxyalkanoate (mcl-PHA) depolymerases reveal mechanism of activity“

Plastic pollution is a major environmental issue, contributing to increased carbon-dioxide emissions and harming ecosystems. Biodegradable plastics, like polyhydroxyalkanoates (PHAs), offer a potential solution due to their eco-friendly properties. However, efficient ways to break them down are essential. This study introduces two new compounds that help measure the activity of enzymes responsible for breaking down PHAs. The new test presented in the study is quick, easy, and works at higher temperatures, making it useful for studying the degradation process. The research also uncovers important details about how enzymes interact with PHAs, and points to the key areas in the enzyme structure that allow them to target and break down the plastic.

This research is part of the dissertation of Marija Nenadović, who is doing her PhD in IMGGE under the mentorship of Dr. Jasmina Nikodinović-Runić. The study was carried out in collaboration with the Faculty of Science, University of Zagreb and University of Belgrade – Faculty of Chemistry.