Sanja Srzentić Dražilov

Research Associate
Laboratory for Molecular Biomedicine

Institute of Molecular Genetics and Genetic Engineering (IMGGE),
University of Belgrade

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mobile: +381 65 3976 445
Phone: +381 11 397 64 45
Fax: +381 11 397 58 08
E-mail: sanja.srzentic@imgge.bg.ac.rs

EDUCATION

2015 - PhD in Molecular Biology, Faculty of Biology (FB), University of Belgrade (UB) (Thesis: Molecular markers of impaired coagulation, inflammation, apoptosis, formation and bone remodeling processes in Legg-Calve-Perthes’ disease)
2010 - Diploma (equivalent to M.Sc.) in Molecular biology and physiology, FB, UB

RESEARCH EXPERIENCE

2016 - Research Associate at Laboratory for Molecular Biomedicine, IMGGE
2012 - 2016 - Research Assistant at Laboratory for Molecular Biomedicine, IMGGE
2011 - 2012 - Research Trainee at Laboratory for Molecular Hematology (today Laboratory for Molecular Biomedicine), IMGGE
2014 – Practical training at Department of Orthopedics, University Medical Center Utrecht, The Netherlands

CAREER HISTORY

2011 to present - Researcher at Laboratory for Molecular Biomedicine, IMGGE, UB

RESEARCH INTEREST

The area of my scientific interest is the study of the molecular basis of Leg-Calve-Perthes (LCP) disease, idiopathic avascular osteonecrosis (AVN) of the femoral head in children. Although this disease was described more than 100 years ago, its etiology and pathogenesis are still unclear. The aim of my research is to identify molecular markers of LCP diseases, which would contribute to understanding of its pathophysiology and the development of new therapeutic approaches. Clinical trials have shown that therapy with autologous mesenchymal stem cells (MSC) gave very good results for the treatment of AVN. I think that research of the therapeutic potential of MSC is very important because it will be one of the most attractive therapeutic approaches for the treatment of AVN in the future.

SELECTED PUBLICATIONS

1. Klaassen K, Stankovic B, Kotur N, Djordjevic M, Zukic B, Nikcevic G, Ugrin M, Spasovski V, Srzentic S, Pavlovic S, Stojiljkovic M. New PAH gene promoter KLF1 and 3'-region C/EBPalpha motifs influence transcription in vitro. J Appl Genet. 2016 Jul 22. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/27447460

2. Srzentić S, Nikčević G, Spasovski D, Baščarević Z, Živković Z, Terzic-Šupić Z, Matanović D, Djordjević V, Pavlović S, Spasovski V. Predictive genetic markers of coagulation, inflammation and apoptosis in Perthes disease-Serbian experience. Eur J Pediatr. 2015 Aug;174(8):1085-92. https://www.ncbi.nlm.nih.gov/pubmed/25754626

3. Srzentic S, Spasovski V, Spasovski D, Zivkovic Z, Matanovic D, Bascarevic Z, Terzic Supic Z, Stojiljkovic M, Karan-Djurasevic T, Stankovic B, Pavlovic S, Nikcevic G, Vukasinovic Z. Association of gene variants in TLR4 and IL-6 genes with Perthes disease. Srp Arh Celok Lek; 2014, 142(7-8):450-6. http://www.ncbi.nlm.nih.gov/pubmed/25233690

4. Jančić I, Arsenović-Ranin N, Sefik-Bukilica M, Zivojinović S, Damjanov N, Spasovski V, Srzentić S, Stanković B, Pavlović S. -174G/C interleukin-6 gene promoter polymorphism predicts therapeutic response to etanercept in rheumatoid arthritis. Rheumatology International, 2013; 33(6): 1481-6. http://www.ncbi.nlm.nih.gov/pubmed/23233117

5. Spasovski V, Tosic N, Nikcevic G, Stojiljkovic M, Zukic B, Radmilovic M, Karan-Djurasevic T, Srzentic S, Colovic M, Pavlovic S. The influence of novel transcriptional regulatory element in intron 14 on the expression of Janus kinase 2 gene in myeloproliferative neoplasms. Journal of Applied Genetics, 2013 Feb;54(1):21-6. http://www.ncbi.nlm.nih.gov/pubmed/23188718

6. Karan-Djurasevic T, Palibrk V, Kostic T, Spasovski V, Nikcevic G, Srzentic S, Colovic N, Colovic M, Vidovic A, Antic D, Mihailjevic B, Pavlovic S, Tosic N. Mutational status and gene repertoire of IGHV-IGHD-IGHJ rearrangements in Serbian chronic lymphocytic leukemia patients. Clinical Lymphoma, Myeloma & Leukemia, 2012 Aug;12(4):252-60. http://www.ncbi.nlm.nih.gov/pubmed/22560084

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