Research Associate
Laboratory for human molecular genetics

Institute of molecular genetics and genetic engineering (IMGGE)
University of Belgrade

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mob:    +381 65 3976212
Tel:      +381 11 3976212
Fax:     +381 11 397 58 08
E-mail: schwirtlich@imgge.bg.ac.rs

EDUCATION

2009 - PhD in Medical Sciences, Semmelweiss University, Budapest, Hungary. In 2012, nostrificated as PhD in Biological Sciences, Faculty of Biology (FB), UB (Molecular components and functionality of the GABA signaling during development: a study on two model systems)

1998 - B.Sc. in Molecular Biology and Physiology, FB, University of Belgrade

RESEARCH EXPERIENCE

2012 - Research Associate,
Institute of molecular genetics and genetic engineering (IMGGE)
University of Belgrade

CAREER HISTORY

2012 - esearch Associate,Laboratory for human molecular genetics
Institute of molecular genetics and genetic engineering (IMGGE)
University of Belgrade

2001 - 2010 - Research Fellow, Laboratory of Molecular Biology and Genetics, Institute of

                           Experimental Medicine

                           Hungarian Academy of Sciences,

                           Budapest, Hungary

1998 - 2001 - Research Trainee, Department of Neurobiology, Institute for Biological        Research “Sinisa Stankovic”, Belgrade, Serbia 

RESEARCH INTEREST

Study on expression and function of SOXB1(SOX1, SOX2, SOX3) and SOXB2 (SOX14 and SOX21) members of SOXB transcription factors during proliferation of embryonic and cancer stem cells. Furthermore, SOXB transcription factors involvement in the regulation of numerous developmental processes in the brain.

SELECTED PUBLICATIONS

In press:

  1. Drakulic D, Marjanovic Vicentic J, Schwirtlich M, Tosic J, Krstic A, Klajn
    A, Stevanovic M. The overexpression of SOX2 affects the migration of human
    teratocarcinoma cell line NT2/D1. An. Acad. Bras. Ciênc., 2014
  2. Klajn A, Drakulic D, Tosic M, Pavkovic Z, Schwirtlich M, Stevanovic M.
    Effects of constitutive SOX2 overexpression on neural differentiation of
    NT2/D1 cells. Biochemistry (Moscow), 2014

Published:

  1. Mojsin M, Vicentic JM, Schwirtlich M, Topalovic V, Stevanovic M. Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/β-catenin signaling. Food Funct. 2014 Oct 24;5(10):2564-73.  http://www.ncbi.nlm.nih.gov/pubmed/25138740
  2. Vastagh C, Schwirtlich M, Kwakowsky A, Erdélyi F, Margolis FL, Yanagawa Y, Katarova Z, Szabó G. The spatio-temporal segregation of GAD forms defines distinct GABA signaling functions in the developing mouse olfactory system and provides novel insights into the origin and migration of GnRH neurons. Dev Neurobiol. 2014 Aug 14. http://www.ncbi.nlm.nih.gov/pubmed/25125027
  3. Popovic J, Stanisavljevic D, Schwirtlich M, Klajn A, Marjanovic J, Stevanovic M. Expression analysis of SOX14 during retinoic acid induced neural differentiation of embryonal carcinoma cells and assessment of the effect of its ectopic expression on SOXB members in HeLa cells. PLoS One. 2014 Mar 17;9(3):e91852. http://www.ncbi.nlm.nih.gov/pubmed/24637840
  4. Schwirtlich M, Kwakowsky A, Emri Z, Antal K, Lacza Z, Cselenyák A, Katarova Z, Szabó G. GABAergic signaling in primary lens epithelial and lentoid cells and its involvement in intracellular Ca2+ modulation. Cell Calcium. 2011 Oct;50(4):381-92. http://www.ncbi.nlm.nih.gov/pubmed/21820173
  5. Schwirtlich M, Emri Z, Antal K, Máté Z, Katarova Z, Szabó G. GABA(A) and GABA(B) receptors of distinct properties affect oppositely the proliferation of mouse embryonic stem cells through synergistic elevation of intracellular Ca(2+). FASEB J. 2010 Apr;24(4):1218-28. http://www.ncbi.nlm.nih.gov/pubmed/19959723
  6. Kwakowsky A, Schwirtlich M, Kooy F, Abrahám I, Máté Z, Katarova Z, Szabó G. GABA neurotransmitter signaling in the developing mouse lens: dynamic regulation of components and functionality. Dev Dyn. 2008 Dec;237(12):3830-41. http://www.ncbi.nlm.nih.gov/pubmed/18985723
    1. Kwakowsky A, Schwirtlich M, Zhang Q, Eisenstat DD, Erdélyi F, Baranyi M, Katarova ZD, Szabó G. GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: correlation with Dlx2 and Dlx5. Dev Dyn. 2007 Dec;236(12):3532-44.  http://www.ncbi.nlm.nih.gov/pubmed/17969168