Research Associate
Laboratory for human molecular genetics

Institute of molecular genetics and genetic engineering (IMGGE),
University of Belgrade

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mobile:   +381 64  3976 212                          
Phone:   +381 11  3976 212
Fax:       +381 11 397 58 08
E-mail: mojsin@imgge.bg.ac.rs

EDUCATION

2008 - PhD in Biology, Faculty of Biology (FB), UB (The role of TALE transcription factors in the retinoic acid induced activation of SOX3 gene)

2000 - M.Sc. in Biology, FB, UB

1997 - B.Sc. in Molecular biology and physiology, FB, University of Belgrade

RESEARCH EXPERIENCE

2009 -  Research Associate,IMGGE

2000 - 2009 - Research Assistant, IMGGE

1997 - 2000 - Research Trainee, IMGGE

CAREER HISTORY

2011 - Deputy Head of Laboratory for human molecular genetics, IMGGE

2013 - Lecturer on Faculty of Biology, University of Belgrade on Doctoral study program Molecular biology of eukaryotes

2011 - Member of Serbian biological society

2011 - Member of Serbian genetic society

RESEARCH INTEREST

Mechanisms involved in the regulation of human SOX3 gene expression during neural differentiation: transcription factors, signalling pathways, epigenetic modifications

The role of Wnt/β-catenin signaling pathway in the regulation of human SOXB1 genes (SOX1, SOX2 and SOX3) expression

In vitro examination of bioactive compounds (effects on cell viability, proliferation, apoptosis, cel adhesion, migration capacity and redox status) in order to evaluate their potential for improving human nutrition and health.

SELECTED PUBLICATIONS

1. Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/β-catenin signaling.

Mojsin M, Vicentic JM, Schwirtlich M, Topalovic V, Stevanovic M.

Food Funct. 2014 Oct 24;5(10):2564-73. doi: 10.1039/c4fo00484a. Epub 2014 Aug 20.

http://www.ncbi.nlm.nih.gov/pubmed/25138740

2. Construction and functional analysis of novel dominant-negative mutant of human SOX18 protein.

Milivojevic M, Petrovic I, Kovacevic-Grujicic N, Popovic J,Mojsin M, Stevanovic M.

Biochemistry (Mosc). 2013 Nov;78(11):1287-92. doi: 10.1134/S0006297913110096.

http://www.ncbi.nlm.nih.gov/pubmed/24460943

3. Cyclic AMP response element binding (CREB) protein acts as a positive regulator of SOX3 gene expression in NT2/D1 cells.

Kovacevic-Grujicic N,Mojsin M, Popovic J, Petrovic I, Topalovic V, Stevanovic M.

BMB Rep. 2014 Apr;47(4):197-202.

http://www.ncbi.nlm.nih.gov/pubmed/24257117

4. TG-interacting factor (TGIF) downregulates SOX3 gene expression in the NT2/D1 cell line.

Mojsin M, Popovic J, Kovacevic Grujicic N, Stevanovic M.

J Genet Genomics. 2012 Jan;39(1):19-27. doi: 10.1016/j.jgg.2011.11.006. Epub 2011 Dec 24.

http://www.ncbi.nlm.nih.gov/pubmed/22293114

5. Regulation of the SOX3 gene expression by retinoid receptors.

Nikčević G, Kovačević-Grujičić N,Mojsin M, Krstić A, Savić T, Stevanović M.

Physiol Res. 2011;60 Suppl 1:S83-91. Epub 2011 Jul 19. Review.

http://www.ncbi.nlm.nih.gov/pubmed/21777018

6. Comparative analysis of SOX3 protein orthologs: Expansion of homopolymeric amino acid tracts during vertebrate evolution.

Mojsin M, Kovacevic-Grujicic N, Krstic A, Popovic J, Milivojevic M, Stevanovic M.

Biochem Genet. 2010 Aug;48(7-8):612-23. doi: 10.1007/s10528-010-9343-2. Epub 2010 May 21.\

http://www.ncbi.nlm.nih.gov/pubmed/20495863

7. PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region.

Mojsin M, Stevanovic M.

Biochem J. 2009 Dec 14;425(1):107-16. doi: 10.1042/BJ20090694.

http://www.ncbi.nlm.nih.gov/pubmed/19799567

8. Regulation of SOX3 gene expression is driven by multiple NF-Y binding elements.

Krstic A,Mojsin M, Stevanovic M.

Arch Biochem Biophys. 2007 Nov 15;467(2):163-73. Epub 2007 Sep 7.

http://www.ncbi.nlm.nih.gov/pubmed/17910945

9. Comparison of promoter regions of SOX3, SOX14 and SOX18 orthologs in mammals.

Kovacevic-Grujicic N,Mojsin M, Djurovic J, Petrovic I, Stevanovic M.

DNA Seq. 2008 Jun;19(3):185-94.

http://www.ncbi.nlm.nih.gov/pubmed/17852354

10. Mapping of the RXRalpha binding elements involved in retinoic acid induced transcriptional activation of the human SOX3 gene.

Mojsin M, Grujicić NK, Nikcević G, Krstić A, Savić T, Stevanović M.

Neurosci Res. 2006 Dec;56(4):409-18. Epub 2006 Sep 26.

http://www.ncbi.nlm.nih.gov/pubmed/17005281

11. Functional characterization of the human SOX3 promoter: identification of transcription factors implicated in basal promoter activity.

Kovacevic Grujicic N,Mojsin M, Krstic A, Stevanovic M.

Gene. 2005 Jan 3;344:287-97. Epub 2004 Dec 10.

http://www.ncbi.nlm.nih.gov/pubmed/15656994