Vladanka Topalović Vuković

Istraživač saradnik
Laboratorija za humanu molekularnu genetiku

Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI),
Univerzitet u Beogradu,

V. Stepe 444a, 11010 Beograd, Srbija
Mob:   +381 65 3976 212
Tel:     +381 11 3976 212
Fax:    +381 11 397 58 08
E-mail: vladankatopalovic@imgge.bg.ac.rs                                   

OBRAZOVANJE

2011 - Student doktorskih studija, BF, UB
2011 - Diplomirani molekularni biolog i fiziolog, BF, UB

ISTRAŽIVAČKO ISKUSTVO

2014 - Istraživač saradnik, IMGGI, UB
2012 - 2014 - Istraživač pripravnik, IMGGI, UB

RADNO ISKUSTVO

2012 - Istraživač, Laboratorija za humanu molekularnu genetiku, IMGGI, UB
2013-2014 - stipendista Erasmus Mundus Sigma programa, Department of BioSciences, University of Milan, Milano, Italija
2010 - stipendista Letnje istraživačke škole, École polytechnique fédérale de Lausanne, Lozana, Švajcarska           

OBLAST NAUČNOG INTERESOVANJA

  • Analiza uloge epigenetičkih mehanizama u regulaciji ekspresije humanih SOXB1 gena tokom procesa neuralne diferencijacije
  • Izučavanje interakcija Wnt signalnog puta i humanih SOXB1 gena
  • Analiza molekularnog diverziteta srpske populacije bazirana na polimorfizmima mitohondrijalne DNK

ODABRANI NAUČNI RADOVI

Epigenetic regulation of human SOX3 gene expression during early phases of neural differentiation of NT2/D1 cells. Topalovic V, Krstic A, Schwirtlich M, Dolfini D, Mantovani R, Stevanovic M, Mojsin M. PLoS One 2017;12(9): e0184099 https://www.ncbi.nlm.nih.gov/pubmed/28886103 

Histone Modifications on the Promoters of Human OCT4 and NANOG Genes at the Onset of Neural Differentiation of NT2/D1 Cells. Topalovic V, Schwirtlich M, Stevanovic M, Mojsin M. Biochemistry Moscow 2017;82(16):715-722 https://www.ncbi.nlm.nih.gov/pubmed/28601081 

SOX14 activates the p53 signaling pathway and induces apoptosis in a cervical carcinoma cell line. Stanisavljevic D, Petrovic I, Vukovic V, Schwirtlich M, Gredic M, Stevanovic M, Popovic J. PLoS One 2017;12(9): e0184686  https://www.ncbi.nlm.nih.gov/pubmed/28926586 

Mitochondrial super-haplogroup U diversity in Serbians. Davidovic S, Malyarchuk B, Aleksic J, Derenko M, Topalovic V, Litvinov A, Skonjeczna K, Rogalla U, Grzybowski T, Stevanovic M, Kovacevic-Grujicic N. Ann Hum Biol 2017; 44(5):408-418 https://www.ncbi.nlm.nih.gov/pubmed/28140657 

Crosstalk between SOXB1 proteins and WNT/β-catenin signaling in NT2/D1 cells. Mojsin M, Topalovic V, Vicentic JM, Schwirtlich M, Stanisavljevic D, Drakulic D, Stevanovic M. Histochem Cell Biol 2015; 144(5):429-441  https://www.ncbi.nlm.nih.gov/pubmed/26239426 

Antioxidant and antiproliferative activity of chokeberry juice phenolics during in vitro simulated digestion in the presence of food matrix. Stanisavljevic N, Samardzic J, Jankovic T, Savikin K, Mojsin M, Topalovic V, Stevanovic M. Food Chem 2015; 175: 516-522 https://www.ncbi.nlm.nih.gov/pubmed/25577114  

The influence of combined oral contraceptives containing drospirenone on hypothalamic-pituitary-adrenocortical axis activity and glucocorticoid receptor expression and function in women with polycystic ovary syndrome. Macut Dj, Bozic Antic I, Nestorov J, Topalovic V, Panidis D, Kastratovic Kotlica B, Papadakis E, Matic G, Vojnovic Milutinovic D.. Hormones, 2015; 14(1):109-117
https://www.ncbi.nlm.nih.gov/pubmed/25402380 

Transcription factor NF-Y inhibits cell growth and decreases SOX2 expression in human embryonal carcinoma cell line NT2/D1. Mojsin M, Topalovic V, Vicentic JM, Stevanovic M. Biochemistry Moscow 2015; 80(2):202-207  https://www.ncbi.nlm.nih.gov/pubmed/25756534 

Mitochondrial DNA perspective of Serbian genetic diversity. Davidovic S, Malyarchuk B, Aleksic JM, Derenko M, Topalovic V, Litvinov A, Stevanovic M, Kovacevic-Grujicic N. Am J Phys Anthropol 2015; 156(3):449-465 https://www.ncbi.nlm.nih.gov/pubmed/25418795  

Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/beta-catenin signaling. Mojsin M, Vicentic JM, Schwirtlich M, Topalovic V, Stevanovic M. Food Funct 2014; 5: 2564-2573  https://www.ncbi.nlm.nih.gov/pubmed/25138740 

Cyclic AMP response element binding (CREB) protein acts as a positive regulator of SOX3 gene expression in NT2/D1 cells. Kovacevic-Grujicic N, Mojsin M, Popovic J, Petrovic I, Topalovic V, Stevanovic M. BMB Rep 2014; 47: 197-202 https://www.ncbi.nlm.nih.gov/pubmed/24257117 

Quercetin and lithium chloride modulate Wnt signaling in pluripotent embryonal carcinoma NT2/D1 cells. Mojsin M, Topalovic V, Marjanovic J, Stevanovic M. Archives of Biological Sciences, 2013; 65(1); 201-209 http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641301201M#.VE9nmDTF-2Y 

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