Sonja Pavlović

Naučni savetnik
Laboratorija za molekularnu biomedicinu

Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI),
Univerzitet u Beogradu,

Vojvode Stepe 444a, 11042 Beograd 152, Srbija
Mob:  +381 65 397 64 45
Tel:    +381 11 397 64 45
Fax:   +381 11 397 58 08
E-mail: sonya@imgge.bg.ac.rs                              

OBRAZOVANJE

2001 - Doktor bioloških nauka, Biološki fakultet (BF), Univerzitet u Beogradu (UB),
(Molekularna genetika talasemijskih sindroma: korelacija između molekularne patologije i fenotipa)
1996 - Magistar bioloških nauka, BF, UB
1992 - Diplomirani molekularni biolog i fiziolog, BF, UB

ISTRAŽIVAČKO ISKUSTVO

2011 - Naučni savetnik, IMGGI, UB
2007 - 2011 - Viši naučni saradnik, IMGGI, UB
2002 – 2007 - Naučni saradnik, IMGGI, UB
1996 - 2002 - Istraživač saradnik, IMGGI, UB
1993 - 1996 - Istraživač pripravnik, IMGGI, UB

RADNO ISKUSTVO

2015 - Rukovodilac Laboratorije za molekularnu biomedicinu (LMB) IMGGI
2013
- Rukovodilac projekata Laboratorije za molekularnu biomedicinu (LMB) IMGGI
2001 - 2013 - Rukovodilac Laboratorije za molekularnu hematologiju (LMH), IMGGI
2000 - Predavač na Doktorskim studijama na Biološkom fakultetu, UB, u okviru studijskog programa Molekularna biologija
2005 - Gostujući istraživač. Centro Ricerca M. Tettamanti, Universita di Milano-Biccoca, H. San Gerardo, Monza, Italy
1999 - Gostujući istraživač. Istituto di Clinica e Biologià dell’Età Evolutiva Università degli Studi, Cagliari, Italy
1993 - 2001 - Istraživač, LMH, IMGGI
1983 - 1994 - Profesor klavira u Muzičkoj školi

OSTALE AKTIVNOSTI           

2009 - Rukovodilac programa za popularizaciju i promociju nauke “Mala škola DNKlogije”
2011 - Nacionalni coordinator za PGENI (Pharmacogenetics for Every Nation Initiative)
2011 - Član Veća instituta UB
2012 - Član Veća grupacije medicinskih nauka UB

ODABRANI PROJEKTI

  1. Evropska mreža za dijagnostiku i terapiju hroničnih neutropenija „EuNet-INNOCHRON” COST akcija CA18233, Evropska komisija, 2019-2023.
  2. Farmakogenomički markeri u imunosupresivnoj i imunomodulatorskoj terapiji: od validiranih markera do kitova za genotipizaciju i kliničkih algoritama (bilateralni projekat između Republike Srbije i Republike Slovenije 451-03-3095/2014-09/45), 2014- 2015.
  3. Unapređenje istraživačkog potencijala IMGGI kroz napredak biomedicinske nauke o retkim bolestima u Srbiji - put ka inovacijama „SERBORDISinn”, (EU FP7-REGPOT-2012-2013-1), Evropska komisija, 2013-2016. Rukovodilac projekta
  4. „RD-CONNECT“ (EU-FP7), Evropska komisija, 2012-2018.
  5. Retke bolesti: molekularna patofiziologija, dijagnostički i terapijski modaliteti i socijalni, etički i pravni aspekti (projekat integralnog i interdisciplinarnog istraživanja, ( III 41004) Ministarstvo za nauku i tehnološki razvoj, Republike Srbije, 2011-2019. Rukovodilac projekta
  6. Researchers’Night Fever „RENIFEVER“ (CSA-SA, FP7-PEOPLE-2011-NIGHT- 287432), Evropska komisija, 2011.Rukovodilac projekta
  7. Mala škola DNKlogije (projekat popularizacije nauke) - Centar ѕa popularizaciju nauke, 2009-2011. Rukvodilac projekta
  8. Poboljšanje zdravlja u Srbiji kroz unapređenje biomedicinske nauke i tehnologije “HISERBS” (SSA, FP6-INCO-026357), Evropska komisija, 2006-2009.
  9. Unapređenje i razvoj naučne i tehnološke izvrsnosti u istraživanju i terapiji leukemija kroz integraciju vodećih nacionalnih leukemijskih mreža i interdisciplinarnih partnerskih grupa u Evropi „European LeukemiaNet“ (FP6, LSHC-CT-2004-503216) Evropska komisija, 2004-2015.

OBLAST NAUČNOG INTERESOVANJA

Molekularna genetika retkih bolesti, talasemija(regulacija transkripcije beta-globinskih gena, geni modifikatori), hematološki maligniteti (molekularni markeri dečje i adultne akutne i hronične mijeloidne i limfoidne leukemije, limfoma i multiplih mijeloma), molekularna osnova metaboličkih bolesti (fenilketonurija, glikogenoze, organske acidurije), molekularna genetika inflamatornih bolesti creva (Kronova bolest, ulcerozni kolitis, celijakija), pulmološke bolesti (tuberkuloza, idiopatska fibroza, plućna hipertenzija, sarkoidoza, primarna cilijarna diskinezija), reumatološke bolesti (sistemska skleroza, miozitis, reumatoidni artritis), ortopedske bolesti, inflamacija, autoimunost, korelacija genotipa i fenotipa, populaciona genetika, ćelijska i genska terapija, farmakogenomika.

Rezultati istraživanja su omogućili uvođenje molekularne dijagnostike za retke bolesti u Srbiji, kao i unapređenje terapijskih protokola za više bolesti.  

PEDAGOŠKA AKTIVNOST

Sonja Pavlović je predavač na Biološkom, Medicinskom i Farmaceutskom fakultetu Univerziteta u Beogradu. Bila je mentor u više od 40 magistarskih i doktorskih teza. 

ODABRANI NAUČNI RADOVI

Sonja Pavlović je objavila više od 180 publikacija u časopisima internacionalnog značaja i nekoliko monografija i poglavlja u knjigama. koji su citirani više od 2000 puta.
https://scholar.google.com/citations?user=Ebd9aX0AAAAJ&hl=en

  1. Klaassen, K., Stankovic, B., Zukic, B., Kotur, N., Gasic, V., Pavlovic, S., Stojiljkovic, M. Functional prediction and comparative population analysis of variants in genes for proteases and innate immunity related to SARS-CoV-2 infection. Infect Genet Evol. 2020 Aug 7;84:104498. doi: 10.1016/j.meegid.2020.104498. https://www.sciencedirect.com/science/article/abs/pii/S1567134820303294
  1. Stankovic B, Kotur N, Gasic V, Klaassen K, Ristivojevic B, Stojiljkovic M, Pavlovic S, Zukic B. Pharmacogenomics landscape of COVID-19 therapy response in Serbian population and comparison with worldwide populations. Journal of Medical Biochemistry (2020);39(4),:488-499. Doi: 10.5114/aoms.2020.96537. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710379/
  1. Pavlovic S, Kotur N, Stankovic B, Zukic B, Gasic V, Dokmanovic L. Pharmacogenomic and Pharmacotranscriptomic Profiling of Childhood Acute Lymphoblastic Leukemia: Paving the Way to Personalized Treatment. Genes (Basel). 2019 Mar 1;10(3). pii: E191. doi: 10.3390/genes10030191. https://www.mdpi.com/2073-4425/10/3/191
  1. Komazec J, Zdravkovic V, Sajic S, Jesic M, Andjelkovic M, Pavlovic S, Ugrin M. The importance of combined NGS and MLPA genetic tests for differential diagnosis of maturity onset diabetes of the young. Endokrynol Pol. 2019;70(1):28-36. doi: 10.5603/EP.a2018.0064. Epub 2018 Sep 27. https://journals.viamedica.pl/endokrynologia_polska/article/view/57752
  1. Andjelkovic M, Minic P, Vreca M, Stojiljkovic M, Skakic A, Sovtic A, Rodic M, Skodric-Trifunovic V, Maric N, Visekruna J, Spasovski V, Pavlovic S. Genomic profiling supports the diagnosis of primary ciliary dyskinesia and reveals novel candidate genes and genetic variants. PLoS One. ; 13(10):e0205422; doi: 10.1371/journal.pone.0205422. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205422
  1. Spasovski D, Spasovski V, Bascarevic Z, Stojiljkovic M, Vreca M, Andjelkovic M, Pavlovic S. Intra-articular Injection of Autologous Adipose Derived Mesenchymal Stem Cells in Treatment of Knee Osteoarthritis. The Journal of Gene Medicine, 2018; 20(1). https://doi.org/10.1002/jgm.3002
  1. Dragasevic S, Stankovic B, Milosavljevic T, Sokic-Milutinovic A, Lukic S, Alempijevic T, Zukic B, Kotur N, Nikcevic G, Pavlovic S, Popovic D. Genetic and environmental factors significant for the presentation and development of inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2017 Aug;29(8):909-915. https://www.ingentaconnect.com/content/wk/ejghe/2017/00000029/00000008/art00007
  1. Skakic A, Djordjevic M, Sarajlija A, Klaassen K, Tosic N, Kecman B, Ugrin M, Spasovski V, Pavlovic S, Stojiljkovic M. Genetic characterization of GSD I in Serbian population revealed unexpectedly high incidence of GSD Ib and three novel SLC37A4 variants. Clin Genet. 2017 Jul 7. doi: 10.1111/cge.13093. https://onlinelibrary.wiley.com/doi/abs/10.1111/cge.13093
  1. Viennas E, Komianou A, Mizzi C, Stojiljkovic M, Mitropoulou C, Muilu J, Vihinen M, Grypioti P, Papadaki S, Pavlidis C, Zukic B, Katsila T, van der Spek PJ, Pavlovic S, Tzimas G, Patrinos GP. Expanded national database collection and data coverage in the FINDbase worldwide database for clinically relevant genomic variation allele frequencies. Nucleic Acids Res. 2017 Jan 4;45(D1):D846-D853 https://academic.oup.com/nar/article/45/D1/D846/2290898?login=true
  1. Mizzi C, Dalabira E, Kumuthini J, Dzimiri N, Balogh I, Başak N, Böhm R, Borg J, Borgiani P, Bozina N, Bruckmueller H, Burzynska B, Carracedo A, Cascorbi I, Deltas C, Dolzan V, Fenech A, Grech G, Kasiulevicius V, Kádaši Ľ, Kučinskas V, Khusnutdinova E, Loukas YL, Macek M Jr, Makukh H, Mathijssen R, Mitropoulos K, Mitropoulou C, Novelli G, Papantoni I, Pavlovic S, Saglio G, Setric J, Stojiljkovic M, Stubbs AP, Squassina A, Torres M, Turnovec M, van Schaik RH, Voskarides K, Wakil SM, Werk A, Del Zompo M, Zukic B, Katsila T, Lee MT, Motsinger-Rief A, Mc Leod HL, van der Spek PJ, Patrinos GP. A European spectrum of pharmacogenomic biomarkers: Implications for clinical pharmacogenomics. PLoS One. 2016 Sep 16;11(9):e0162866. doi: 10.1371/journal.pone.0162866 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162866 .
  1. Stojiljkovic M, Klaassen K, Djordjevic M, Sarajlija A, Brasil S, Kecman B, Grkovic S, Kostic J, Rodriguez-Pombo P, Desviat LR, Pavlovic S, Perez B. Molecular and phenotypic characteristics of seven novel mutations causing branched-chain organic acidurias. Clin Genet. 2016 Sep;90(3):252-7. https://onlinelibrary.wiley.com/doi/abs/10.1111/cge.12751
  1. Todorovic Balint M, Jelicic J, Mihaljevic B, Kostic J, Stanic B, Balint B, Pejanovic N, Lucic B, Tosic N, Marjanovic I, Stojiljkovic M, Karan-Djurasevic T, Perisic O, Rakocevic G, Popovic M, Raicevic S, Bila J, Antic D, Andjelic B, Pavlovic S. Gene Mutation Profiles in Primary Diffuse Large B Cell Lymphoma of Central Nervous System: Next Generation Sequencing Analyses. Int J Mol Sci. 2016 May 6;17(5). pii: E683. doi: 10.3390/ijms17050683. https://www.mdpi.com/1422-0067/17/5/683
  1. Milacic I, Barac M, Milenkovic T, Ugrin M, Klaassen K, Skakic A, Jesic M, Joksic I, Mitrovic K, Todorovic S, Vujovic S, Pavlovic S, Stojiljkovic M. Molecular genetic study of congenital adrenal hyperplasia in Serbia: novel p.Leu129Pro and p.Ser165Pro CYP21A2 gene mutations. J Endocrinol Invest. 2015; 38(11): 1199-210. https://link.springer.com/article/10.1007/s40618-015-0366-8
  1. Stankovic B, Dragasevic S, Popovic D, Zukic B, Kotur N, Sokic-Milutinovic A, Alempijevic T, Lukic S, Milosavljevic T, Nikcevic G, Pavlovic S. Variations in inflammatory genes as molecular markers for prediction of inflammatory bowel disease occurrence. J Dig Dis. 2015; 16(12):723-33. https://onlinelibrary.wiley.com/doi/abs/10.1111/1751-2980.12281
  1. Pavlovic S, Ugrin M, Stojiljkovic M. Novel Therapy Approaches in Beta Thalassemia Syndromes — A Role of Genetic Modifiers In: Hemoglobin Disorders (ed: Anjana Munshi), pp. 75-94 (2015). InTech, Rijeka, Croatia.
    https://books.google.rs/books?hl=en&lr=&id=9GmQDwAAQBAJ&oi=fnd&pg=PA137&dq=info:i2Xgp_wJtiIJ:scholar.google.com&ots=lzX_ZubLtp&sig=8Exe3sB3x-ZYKZ8w-BOn9Wnmpso&redir_esc=y#v=onepage&q&f=false 
  1. Srzentić S, Nikčević G, Spasovski D, Baščarević Z, Živković Z, Terzic-Šupić Z, Matanović D, Djordjević V, Pavlović S, Spasovski V. Predictive genetic markers of coagulation, inflammation and apoptosis in Perthes disease - Serbian experience. European Journal of Pediatrics. 2015; 174(8): 1085-92.
    https://link.springer.com/article/10.1007/s00431-015-2510-z
  1. Paschou P, Drineas P, Yannaki E, Razou A, Kanaki K, Tsetsos F, Padmanabhuni SS, Michalodimitrakis M, Renda MC, Pavlovic S, Anagnostopoulos A, Stamatoyannopoulos JA, Kidd KK, Stamatoyannopoulos G. Maritime route of colonization of Europe. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9211-6 http://www.ncbi.nlm.nih.gov/pubmed/24927591
  1. Rodic P, Pavlovic S, Kostic T, Suvajdzic Vukovic N, Djordjevic M, Sumarac Z, Dajak M, Bonaci Nikolic B, Janic D. Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease. Blood Cells Mol Dis. 2013 50: 222-225. http://www.ncbi.nlm.nih.gov/pubmed/23265739
  1. Jančić I, Arsenović-Ranin N, Sefik-Bukilica M, Zivojinović S, Damjanov N, Spasovski V, Srzentić S, Stanković B, Pavlović S. -174G/C interleukin-6 gene promoter polymorphism predicts therapeutic response to etanercept in rheumatoid arthritis. Rheumatol Int. 2013 Jun;33(6):1481-6. http://www.ncbi.nlm.nih.gov/pubmed/23233117
  1. Giardine B, Borg J, Higgs D, Peterson K, Philipsen S, Maglott D, Singleton B, Anstee D, Basak AN, Clark B, Costa F, Faustino P, Fedosyuk H, Felice A, Francina A, Galanello R, Gallivan M, Georgitsi M, Gibbons R, Giordano P, Harteveld C, Hoyer J, Jarvis M, Joly P, Kanavakis E, Kollia P, Menzel S, Miller W, Moradkhani K, Old J, Papachatzopoulou A, Papadakis M, Papadopoulos P, Pavlovic S, Perseu L, Radmilovic M, Riemer C, Satta S, Schrijver I, Stojiljkovic M, Thein SL, Traeger-Synodinos J, Tully R, Wada T, Waye J, Wiemann C, Zukic B, Chui D, Wajcman H, Hardison R, Patrinos P. Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach. Nat Genet 2011: 43(4): 295-301. http://www.ncbi.nlm.nih.gov/pubmed/21423179
  1. Pavlovic S. TPMT gene polymorphisms: on the doorstep of personalized medicine. Indian J Med Res. 2009 May;129(5):478-80. http://www.ncbi.nlm.nih.gov/pubmed/19675373
  1. Stojiljkovic M, Jovanovic J, Djordjevic M, Grkovic S, Cvorkov Drazic M, Petrucev B, Tosic N, Karan Djurasevic T, Stojanov L, Pavlovic S. Molecular and phenotypic characteristics of patients with phenylketonuria in Serbia and Montenegro. Clin Genet. 2006 Aug;70(2):151-5. http://www.ncbi.nlm.nih.gov/pubmed/16879198
  1. Pavlovic S, Urosevic J, Poznanic J, Perisic Lj, Petrucev B, Tosic N, Krivokapic-Dokmanovic L, Janic D, Cvorkov-Drazic M, Bunjevacki G. (2005) Molecular basis and origin of thalassemia syndromes in Serbia. Acta Haematologica 113, 175-180. http://www.ncbi.nlm.nih.gov/pubmed/15870487

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