Akademik Milena Stevanović

Akademik, naučni savetnik

Redovni član Srpske akademije nauka i umetnosti
Redovni profesor, Biološki fakultet Univerziteta u Beogradu
Naučni savetnik
Laboratorija za humanu molekularnu genetiku

Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI),
Univerzitet u Beogradu (UB)

V. Stepe 444a,11010 Beograd, Srbija
Mob:   +381 64 8044085
Tel:      +381 11 397 62 12
Fax:    +381 11 397 58 08
E-mail: milenastevanovic@imgge.bg.ac.rs

OBRAZOVANJE

1990 - doktor bioloških nauka, Biološki fakultet (BF), Univerzitet u Beogradu (UB),
(TEZA: Strukturna analiza tri haplotipa β familije gena za globinske lance hemoglobina pacova Rattus Norvegicus)
1987 -  magistar bioloških nauka, BF, UB
1983 - diplomirani molekularni biolog, BF, UB 

ISTRAŽIVAČKO ISKUSTVO

2000 - naučni savetnik, IMGGI, UB
1996 - 2000 - viši naučni saradnik, IMGGI
1991 - 1996 - naučni saradnik, IMGGI
1988 - 1991 - istraživač saradnik, IMGGI
1986 - 1988 - istraživač pripravnik, IMGGI, UB 

RADNO ISKUSTVO        

2017 - redovni profesor, Biološki fakultet, UB
2007- predavač na doktorskim studijama na Biološkom fakultetu, UB, u okviru studijskog programa Molekularna biologija
1999 - 2017 - predavač na osnovnim akademskim studijama na Biološkom fakultetu, UB, predmet Osnovi manipulisanja genima
1994 - rukovodilac Laboratorije za humanu molekularnu genetiku, IMGGE, UB
1992 - 1994 - post-dok,  Departman za genetiku, Univerzitet u Kembridžu, Velika Britanija
1991 - 1992 - post-dok, Kraljevski institut za ispitivanje kancera, London, Velika Britanija
1986 - 1991 - Laboratorija za proučavanje strukture genoma, IMGGE 

OSTALE AKTIVNOSTI           

2017 - član Nacionalnog saveta za naučni u tehnološki razvoj
2016 - član Upravnog odbora Srpskog društva za molekularnu biologiju
2015 - redovni član Srpske akademije nauka i umetnosti
2009 - 2015 - dopisni član Srpske akademije nauka i umetnosti
2007 - 2016 - član Matičnog naučnog odbora za biologiju Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije
2005 - 2014 - član Upravnog odbora Srpskog biološkog društva
2004 -2006 - član Saveta UB
2003 - član Nacionalnog komiteta za bioetiku Srbije UNESCO komisije
2001 - 2007 - član Komisije za biologiju, Ministarstvo za nauku i tehnološki razvoj Republike Srbije
2001 - 2006 - predsednik Naučnog veća IMGGI, UB
1999 – 2011 - predsednik Upravnog odbora (UO) IMGGI
1993 - 2010 - član UO IMGGI 

OBLAST NAUČNOG INTERESOVANJA 

Humana molekularna genetika, genetičko inženjerstvo, molekularnа filogenetika i molekularna citogenetika. Uži naučni interes: Proučavanje strukture i regulacije ekspresije  humanih SOX gena: identifikacija kontrolnih elemenata uključenih u transkripcionu regulaciju ekspresije i proučavanje uloge Wnt i Sonic hedgehog (SHH) signalnih puteva u kontroli ekspresiju ovih gena;  Proučavanje uticaja epigenetičkih mehanizama na kontrolu ekspresije SOX gena; Istraživanje uloge SOX gena u održavanju pluripotentnosti, određivanju sudbine i diferencijaciji ćelija; Proučavanje uloge SOX gena u onkogenezi; Filogenetska analiza varijacija na nivou mitohondrijalne DNK u savremenoj populaciji; Primena fluorescentne in situ hibridizacije  u detekciji mikrodelecionih sindroma.

ODABRANI NAUČNI RADOVI

Popovic J., Klajn A., Paunesku T., Ma Q., Chen S., Lai B., Stevanovic M., Woloschak G. Neuroprotective Role of Selected Antioxidant Agents in Preventing Cisplatin-Induced Damage of Human Neurons In Vitro. Cell Mol Neurobiol. 2019. 39(5):619-636.

https://www.ncbi.nlm.nih.gov/pubmed/30874981

Marjanovic Vicentic J, Drakulic D, Garcia I, Vukovic V, Aldaz P, Puskas N, Nikolic I, Tasic G, Raicevic S, Garros-Regulez L, Sampron N, Atkinson MJ, Anastasov N, Matheu A, Stevanovic M. SOX3 can promote the malignant behavior of glioblastoma cells. Cell Oncol (Dordr). 2018. 42(1):41-54.

https://www.ncbi.nlm.nih.gov/pubmed/30209685

Zaletel I, Schwirtlich M, Perović M, Jovanović M, Stevanović M, Kanazir S, Puškaš N. Early Impairments of Hippocampal Neurogenesis in 5xFAD Mouse Model of Alzheimer's Disease Are Associated with Altered Expression of SOXB Transcription Factors. J Alzheimers Dis. 2018. 65(3):963-976.

https://www.ncbi.nlm.nih.gov/pubmed/30103323

Videnović M, Mojsin M, Stevanović M, Opsenica I, Srdić-Rajić T, Šolaja B. Benzothiazole carbamates and amides as antiproliferative species. Eur J Med Chem. 2018. 157:1096-1114.

https://www.ncbi.nlm.nih.gov/pubmed/30179747

Tosic N., Petrovic I., Grujicic N.K., Davidovic S., Virijevic M., Vukovic NS., Pavlovic S., Stevanovic M. Prognostic significance of SOX2, SOX3, SOX11, SOX14 and SOX18 gene expression in adult de novo acute myeloid leukemia. Leuk Res. 2018. 67:32-38.

https://www.ncbi.nlm.nih.gov/pubmed/29428447

Stanisavljevic D., Petrovic I., Vukovic V., Schwirtlich M., Gredic M., Stevanovic M., Popovic J. SOX14 activates the p53 signaling pathway and induces apoptosis in a cervical carcinoma cell line. PLoS One. 2017. 12(9):e0184686.

https://www.ncbi.nlm.nih.gov/pubmed/28926586

Topalovic V., Krstic A., Schwirtlich M., Dolfini D., Mantovani R., Stevanovic M., Mojsin M. Epigenetic regulation of human SOX3 gene expression during early phases of neural differentiation of NT2/D1 cells. PLoS One. 2017 12(9):e0184099.

https://www.ncbi.nlm.nih.gov/pubmed/28886103

Garcia I., Aldaregia J., Marjanovic Vicentic J., Aldaz P., Moreno-Cugnon L., Torres-Bayona S., Carrasco-Garcia E., Garros-Regulez L., Egaña L,. Rubio A., Pollard S., Stevanovic M., Sampron N., Matheu A. Oncogenic activity of SOX1 in glioblastoma. Sci Rep. 2017. 7:46575.

https://www.ncbi.nlm.nih.gov/pubmed/28425506

Rakonjac M., Cuturilo G., Stevanovic M., Jelicic L., Subotic M., Jovanovic I., Drakulic D. Differences in speech and language abilities between children with 22q11.2 deletion syndrome and children with phenotypic features of 22q11.2 deletion syndrome but without microdeletion. Res Dev Disabil. 2016. 55: 322-329.

https://www.ncbi.nlm.nih.gov/pubmed/27235769

Davidovic S., Malyarchuk B., Aleksic J.M., Derenko M., Topalovic V., Litvinov A., Stevanovic M., Kovacevic-Grujicic N. Mitochondrial DNA perspective of Serbian genetic diversity. Am J Phys Anthropol 2015. 156:449-465.

http://www.ncbi.nlm.nih.gov/pubmed/25418795

Petrovic I., Milivojevic M., Popovic J., Schwirtlich M., Rankovic B., Stevanovic M. SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines. PLoS One. 2015. 10(11):e0143591.

http://www.ncbi.nlm.nih.gov/pubmed/26588701

Popovic J., Stanisavljevic D., Schwirtlich M., Klajn A., Marjanovic J., Stevanovic M. Expression analysis of SOX14 during retinoic acid induced neural differentiation of embryonal carcinoma cells and assessment of the effect of its ectopic expression on SOXB members in HeLa cells. 2014. PLoS One, 9:e91852.

http://www.ncbi.nlm.nih.gov/pubmed/24637840

Popovic J., Klajn A., Petrovic I., Stevanovic M.Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression. 2010. Biochim Biophys Acta: Gene Regulatory Mechanisms, 1799: 411–418.

http://www.ncbi.nlm.nih.gov/pubmed/20074681

Mojsin M., Stevanovic M. PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region. 2010. Biochem J, 425:107-16.

http://www.ncbi.nlm.nih.gov/pubmed/19799567

Nikčević G., Savić T., Kovačević-Grujičić N., Stevanović M. Up-regulation of the SOX3gene expression by retinoic acid: characterization of the novel promoter-response element and the retinoid receptors involved. 2008. J Neurochem, 107: 1206-15.

http://www.ncbi.nlm.nih.gov/pubmed/18786169

Stevanovic M. Modulation of SOX2 and SOX3 gene expression during differentiation of human neuronal precursor cell line NTERA2. 2003. Mol Biol Rep, 30: 127-132.

http://www.ncbi.nlm.nih.gov/pubmed/12841584

Stevanović M., Zuffardi O., Collignone J., Lovell-Badge R., and Goodfellow P. The cDNA sequence and chromosomal location of the human SOX2 gene. 1994. Mamm Genome, 5: 640-642.

http://www.ncbi.nlm.nih.gov/pubmed/7849401

Foster J.W., Dominguez-Steglich M.A., Guioli S., Kwok C., Weller P.A., Stevanović M., Weissenbach J., Mansour S., Young I.D., Goodfellow P.N., Brook J.D., Schafer A.J. Campomelic dysplasia and autosomal sex reversal caused by mutation in an Sry-related gene. 1994. Nature, 372: 525-530.

http://www.ncbi.nlm.nih.gov/pubmed/7990924

Stevanović M., Lovell-Badge R., Collignone J., Goodfellow, P. SOX3 is an X-linked gene related to SRY. 1993. Hum Mol Genet, 2: 2013-2018.

http://www.ncbi.nlm.nih.gov/pubmed/8111369

Farr C.J., Stevanović M., Thomson E.J., Goodfellow P., Cooke, H.J. Telomere-associated chromosome fragmentation: applications in genome manipulation and analysis. 1992. Nat Genet, 2: 275-282.

http://www.ncbi.nlm.nih.gov/pubmed/1303279

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