Marija Švirtlih

Naučni saradnik
Laboratorija za humanu molekularnu genetiku

Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI),
Univerzitet u Beogradu,

V. Stepe 444a, 11010 Beograd, Srbija
Mob: +381 65 3976212
Tel:   +381 11 3976212
Fax:  +381 11 397 58 08
E-mail: schwirtlich@imgge.bg.ac.rs                                   

OBRAZOVANJE

2009 - Doktor medicinskih nauka, smer funcionalne neuroanatomija, Semelvajs Univerzitet, Budimpešta, Republika Madjarska.
Diploma je 2012 nostrifikovana kao diploma doktora bioloških nauka, Biološki fakultet (BF), Univerzitet u Beogradu (UB),
(Naslov teme: Molekularne komponente i funkcija GABA signalizacije tokom razvića)
1998 - Diplomirani biolog i fiziolog, BF, UB

ISTRAŽIVAČKO ISKUSTVO

2012 - naučni saradnik, Institut za molekularnu genetiku i genetičko inženjerstvo, (IMGGI), UB

RADNO ISKUSTVO

2012 - istraživač u  Laboratoriji za humanu molekularnu genetiku,  Instituta   za molekularnu genetiku i genetičko inženjerstvo, (IMGGI), UB
2001 - 2010 - istraživač u Institutu za eksperimentalnu medicinu Madjarske Akademije Nauka, Budimpešta, Republika Madjarska
1998 - 2001 - istraživač na Odeljenju za neurobiologiju, Biološkog instituta Siniša Stanković, UB           

OSTALE AKTIVNOSTI

2012 - član Društva za neuronauke Srbije

OBLAST NAUČNOG INTERESOVANJA

Proučavanje funkcije SOXB1( SOX1, SOX2, SOX3) i SOXB2 (SOX14  i SOX21) članova SOXB familije transkripcionih faktora u regulaciji proliferacije embrionalnih i karcinomskih matičnih ćelija kao i diferencijaciji neuralnih progenitora tokom razvića nervnog sistema.

ODABRANI NAUČNI RADOVI

  • Topalovic V., Krstic A., Schwirtlich M., Dolfini D., Mantovani R., Stevanovic M., Mojsin M. (2017). Epigenetic regulation of human SOX3 gene expression during early phases of neural differentiation of NT2/D1 cells. PLOS ONE.12(9):e0184099. https://www.ncbi.nlm.nih.gov/pubmed/28886103
  • Stanisavljevic D., Petrovic I., Vukovic V., Schwirtlich M., Gredic M., Stevanovic M., Popovic J. (2017). SOX14 activates the p53 signaling pathway and induces apoptosis in a cervical carcinoma cell line. PLOS ONE. 12(9):e0184686. https://www.ncbi.nlm.nih.gov/pubmed/28926586
  • Petrovic I., Milivojevic M., Popovic J., Schwirtlich M., Rankovic B., Stevanovic M. (2015). SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines. PLOS ONE 10(11): e0143591. https://www.ncbi.nlm.nih.gov/pubmed/26588701
  • Mojsin M., Topalovic V., Vicentic JM., Schwirtlich M., Stanisavljevic D., Drakulic D., Stevanovic M. (2015). Crosstalk between SOXB1 proteins and WNT/β-catenin signaling in NT2/D1 cells. Histochem Cell Biol. 144(5): 429-41. https://www.ncbi.nlm.nih.gov/pubmed/26239426
  • Drakulic D, Vicentic JM, Schwirtlich M, Tosic J, Krstic A, Klajn A, Stevanovic M. (2015). The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1. An Acad Bras Cienc. 87(1):389-404. https://www.ncbi.nlm.nih.gov/pubmed/25761220
  • Vastagh C., Schwirtlich M., Kwakowsky A., Erdélyi F., Margolis FL., Yanagawa Y., Katarova Z., Szabó G. (2014). The spatiotemporal segregation of GAD forms defines distinct GABA signaling functions in the developing mouse olfactory system and provides novel insights into the origin and migration of GnRH neurons. Dev Neurobiol. 75(3):249-70. https://www.ncbi.nlm.nih.gov/pubmed/25125027
  • Popovic J., Stanisavljevic D., Schwirtlich M., Klajn A., Marjanovic J., Stevanovic M. (2014). Expression analysis of SOX14 during retinoic acid induced neural differentiation of embryonal carcinoma cells and assessment of the effect of its ectopic expression on SOXB members in HeLa cells. PLOS ONE 9(3):e91852. https://www.ncbi.nlm.nih.gov/pubmed/24637840
  • Schwirtlich M., Kwakowsky A.,  Emri  Zs., Antal K., Lacza Zs., Cselenyák A., Katarova, Z., Szabó, G. (2011) GABAergic signaling in primary lens epithelial and lentoid cells and its involvement in intracellular Ca2+ modulation. Cell Calcium 50(4):381-92. https://www.ncbi.nlm.nih.gov/pubmed/21820173
  • Schwirtlich M., Emri Zs., Antal K., Máté Z., Katarova Z., Szabó G. (2010) GABAA and GABAB receptors of distinct properties affect oppositely the proliferation of mouse embryonic stem cells through synergistic elevation of intracellular Ca2+. FASEB J. 24(4):1218-28. https://www.ncbi.nlm.nih.gov/pubmed/19959723

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