Jasmina Nikodinović-Runić

Naučni savetnik
Laboratorija za molekularnu genetiku i ekologiju mikroorganizama (LMGEM)

Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI),
Univerzitet u Beogradu,

Vojvode Stepe 444a, 11042 Beograd 152, Srbija
Mobile:  +381 65 397 60 34
Phone:  +381 11 397 60 34
Fax:      +381 11 397 58 08
E-mail: jasmina.nikodinovic@imgge.bg.ac.rs

OBRAZOVANJE

2004  - Doktor molekularne genetike i biohemije, Univerzitet Novog Južnog Velsa, Sidnej, Australija (www.unsw.edu.au
(Teza: Molecular genetics of amphotericin biosynthesis in Streptomyces nodosus)
2000 - B.Sc. Molekularna genetika, Univerzitet Zapadnog Sidneja, Sidnej, Australija (www.uws.edu.au)

RADNO ISKUSTVO

2020 - Rukovodilac grupe za Eko-biotehnologiju i razvoj lekova, LMGEM, IMGGI i IMGGE BioICEP tima (www.bioicep.eu)
2014
- Naučni savetnik, Laboratorija za molekularnu genetiku i ekologiju mikroorganizama, IMGGI
2011 - 2014 -Viši naučni saradnik, Laboratorija za molekularnu genetiku i ekologiju mikroorganizama, IMGGI
2006 - 2010 - Viši naučnik istraživač, Grupa za Biokatalizu, UCD, Dablin, Irska (www.ucd.ie)
2004 - 2006 - Postdoktorand, Katedra za hemiju, Univerzitet u Montani, Misula, MT, USA (www.cas.umt.edu)

TEKUĆE SARADNJE

Prof Kevin O’Connor - University College Dublin, Ireland (www.ucd.ie)
Prof Evangelos Topakas - National Technical University of Athens, Athens, Greece (www.ntua.gr)
Prof Nigel D Priestley – University of Montana, MT, USA (www.umt.edu)
Prof Tobias Gulder – Technical University Dresden, Germany (https://tu-dresden.de/)
Prof Miloš Đuran - Institut za hemiju, Prirodno-matematički fakultet, Univerzitet u Kragujevcu, Srbija (www.kg.ac.rs)
Prof Veselin Maslak – Hemijski fakultet, Univerzitet u Beogradu, Srbija (www.chem.bg.ac.rs)
Prof Vladimir Savić – Farmaceutski fakultet, Univerzitet u Beogradu, Srbija (www.pharmacy.bg.ac.rs)
Prof Melina Kalagasidis Krušić – Tehnolosko-metalurski fakultet, Univerzitet u Beogradu, Srbija (www.tmf.bg.ac.rs)

OBLAST NAUČNOG INTERESOVANJA

BIOTEHNOLOGIJA (bioremedijacija, bakterijske fermentacije, poboljsanje bakterijskih sojeva primenom tradicionalnih i molekularnih metoda, Streptomyces spp., Pseudomonas spp.);
BIOKATALIZA (identifikacija novih biokatalizatora, ekspresija i dirigovana evolucija proteina, tautomeraze, lakaze, aminotransferaze, biotransformacije, razvoj i optimizacija biokatalitickih procesa);
NOVI MATERIJALI (biopolimeri, polihidroksialkanoati, nanoceluloza, funkcionalizacija biopolimera);
SEKUNDARNI METABOLITI I BIOAKTIVNA JEDINJENJA IZ BAKTERIJA (biopigmenti, antigljivična i antitumorska jedinjenja)

ODABRANI NAUČNI RADOVI

Bioaktivni molekuli

Andrejević, T.P., Aleksic, I., Počkaj. M., Kljun, J., Milivojevic, D., Stevanović, N.L., Nikodinovic-Runic, J., Turel, I., Djuran, M.I., Glišić, B.Đ. Tailoring copper(II) complexes with pyridine-4,5-dicarboxylate esters for anti-Candida activity. Dalton Trans. (2021) 50, 2627-2638. https://pubmed.ncbi.nlm.nih.gov/33523054/

Sovari, S.N., Vojnovic, S., Bogojevic, S.S., Crochet, A., Pavic, A., Nikodinovic-Runic, J., Zobi, F. Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). Eur J Med Chem. (2020); 205, 112533. https://pubmed.ncbi.nlm.nih.gov/32739550/

Savić, N.D., Petković, B.B., Vojnovic, S., Mojicevic, M., Wadepohl, H., Olaifa, K., Marsili, E., Nikodinovic-Runic, J., Djuran, M.I., Glišić, B.Đ. Dinuclear silver(I) complexes with a pyridine-based macrocyclic type of ligand as antimicrobial agents against clinically relevant species: The influence of the counteranion on the structure diversification of the complexes. Dalton Trans. (2020); 49, 10880-10894. https://pubmed.ncbi.nlm.nih.gov/32716429/

Müller, J.I., Kusserow, K., Hertrampf, G., Pavic, A., Nikodinovic-Runic, J., Gulder, T.A.M. Synthesis and initial biological evaluation of myxocoumarin B. Org Biomol Chem. (2019);17(7):1966-1969. https://www.ncbi.nlm.nih.gov/pubmed/30357251

Lazić J, Ajdačić V, Vojnovic S, Zlatović M, Pekmezovic M, Mogavero S, Opsenica I, Nikodinovic-Runic J. Bis-guanylhydrazones as efficient anti-Candida compounds through DNA interaction. Appl Microbiol Biotechnol. (2018);102(4):1889-1901. https://www.ncbi.nlm.nih.gov/pubmed/29330691

Warżajtis B, Glišić BĐ, Savić ND, Pavic A, Vojnovic S, Veselinović A, Nikodinovic-Runic J, Rychlewska U, Djuran MI. Mononuclear gold(III) complexes with L-histidine-containing dipeptides: tuning the structural and biological properties by variation of the N-terminal amino acid and counter anion. J Inorg Biochem. (2017); (174): 156-68. https://www.ncbi.nlm.nih.gov/pubmed/28675847

Radivojevic J, Skaro S, Senerovic L, Vasiljevic B, Guzik M, Kenny ST, Maslak V, O'Connor KE, Nikodinovic-Runic J. Polyhydroxyalkanoate-based 3-hydroxyoctanoic acid and its derivatives as a platform of bioactive compounds. Appl Microbiol Biotechnol. (2016); 100(1):161-72. http://www.ncbi.nlm.nih.gov/pubmed/26399414

Simic M, Paunovic N, Boric I, Randjelovic J, Vojnovic S, Nikodinovic-Runic J, Pekmezovic M, Savic V. Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies. Bioorg. Med. Chem. Lett. (2016); 26(1):235-9. http://www.ncbi.nlm.nih.gov/pubmed/26586600

Senerovic L, Zivkovic MD, Veselinovic A, Pavic A, Djuran MI, Rajkovic S, Nikodinovic-Runic J. Synthesis and evaluation of series of diazine-bridged dinuclear platinum(II) complexes through in vitro toxicity and molecular modeling: correlation between structure and activity of Pt(II) complexes. J. Med. Chem. (2015); 58(3):1442-51. http://www.ncbi.nlm.nih.gov/pubmed/25551180

Stankovic N, Senerovic L, Ilic-Tomic T, Vasiljevic B, Nikodinovic-Runic J. Properties and applications of undecylprodigiosin and other bacterial prodigiosins. Appl. Microbiol. Biotechnol. (2014); 98, 3841-58. http://www.ncbi.nlm.nih.gov/pubmed/24562326

O'Connor, S., Szwej, E., Nikodinovic-Runic, J., O'Connor, A., Byrne, A.T., Devocelle, M., O'Donovan, N., Gallagher, W.M., Babu, R., Kenny, S.T., Zinn, M., Zulian, Q.R., O'Connor, K.E. The anti-cancer activity of a cationic anti-microbial peptide derived from monomers of polyhydroxyalkanoate. Biomaterials (2013); 34, 2710–18. http://www.ncbi.nlm.nih.gov/pubmed/23343631

Biokataliza i biopolimeri

Simic, S., Jeremic, S., Djokic, L., Bozic, N., Vujcic, Z., Loncar, N., Senthamaraikannan, R., Babu, R., Opsenica, I.M., Nikodinovic-Runic, J. Development of an efficient biocatalytic system based on bacterial laccase for the oxidation of selected 1,4-dihydropyridines. Enzyme Microb Technol. (2020) 132, 109411. https://pubmed.ncbi.nlm.nih.gov/31731971/

Stojanović, G., Nikodinović-Runić, J., Švenderman, S., Kojić, T., Radovanović, M., Mikov, M., Ranđelović, D. Comprehensive characterization of elastomeric polyhydroxyalkanoate and its sensor applications. Mat Sci Eng C. (2020) 111091. https://pubmed.ncbi.nlm.nih.gov/32600695/

Malagurski, I., Frison, R., Maurya, A.K., Neels, A., Andjelkovic, B., Senthamaraikannan, R., Babu, R.P., O'Connor, K.E., Witko, T., Solarz, D., Nikodinovic-Runic, J. Polyhydroxyoctanoate films reinforced with titanium dioxide microfibers for biomedical application. Materials Lett. (2021); 285:129100. https://www.sciencedirect.com/science/article/abs/pii/S0167577X20318073?via%3Dihub

Jeremic, S., Djokic, L., Ajdačić, V., Božinović, N., Pavlovic, V., Manojlović, D.D., Babu, R., Senthamaraikannan, R., Rojas, O., Opsenica, I., Nikodinovic-Runic, J. Production of bacterial nanocellulose (BNC) and its application as a solid support in transition metal catalysed cross-coupling reactions. Int J Biol Macromol. (2019); 129:351-360. https://www.ncbi.nlm.nih.gov/pubmed/30710586

Spasic J, Mandic M, Djokic L, Nikodinovic-Runic J. Streptomyces spp. in the biocatalysis toolbox. Appl Microbiol Biotechnol. 2018;102(8):3513-3536. https://www.ncbi.nlm.nih.gov/pubmed/29502181

Narancic T, Davis R, Nikodinovic-Runic J, O' Connor KE. Recent developments in biocatalysis beyond the laboratory. Biotechnol Lett. 2015; 37(5):943-54. http://www.ncbi.nlm.nih.gov/pubmed/25555685

Guzik MW, Kenny ST, Duane GF, Casey E, Woods T, Babu RP, Nikodinovic-Runic J, Murrey M, O’Connor K. Conversion of post consumer polyethylene to the biodegradable polymer polyhydroxyalkanoate. Appl. Microbiol. Biotechnol. (2014); 98, 4223-32. http://www.ncbi.nlm.nih.gov/pubmed/24413975

Molloy, S., Nikodinovic-Runic, J., Martin, L.B., Hartmann, H., Solano, F., Decker, H., O'Connor, K.E. Engineering of a bacterial tyrosinase for improved catalytic efficiency towards D-tyrosine using random and site directed mutagenesis approaches. Biotechnol. Bioeng. (2013); 110, 1849–57. http://www.ncbi.nlm.nih.gov/pubmed/23381872

Narancic, T., Radivojevic, J., Jovanovic, P., Francuski, D., Bigovic, M., Maslak, V., Savic, V., Vasiljevic, B., O'Connor, K.E., Nikodinovic-Runic, J. Highly efficient Michael-type addition of acetaldehyde to b-nitrostyrenes by whole resting cells of Escherichia coli expressing 4-oxalocrotonate tautomerase. Biores. Technol. (2013); 142, 462–68. http://www.ncbi.nlm.nih.gov/pubmed/23759430

Nikodinovic-Runic, J., Guzik, M., Kenny, S.T., Babu, R., Werker, A., O'Connor, K.E. Carbon-rich wastes as feedstocks for biodegradable polymer (polyhydroxyalkanoate) production using bacteria. Adv. Appl. Microbiol. (2013); 84, 139-200. http://www.ncbi.nlm.nih.gov/pubmed/23763760

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