Laboratorija za molekularnu biomedicinu

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Istraživanje

Laboratorija za molekularnu biomedicinu ima reputaciju postignutu istraživačkim rezultatima i ekpertizom u dijagnostici različitih retkih bolesti u Srbiji i na Balkanu. Napori LMB su usmereni ka istraživanjima molekularne osnove zdravlja i bolesti i translacionoj biomedicini sa ciljem da se u zdravstvenom sistemu primeni personalizovana medicina zasnovana na ličnom genomu pacijenta.

Uspešna saradnja sa brojnim istaknutim centrima i vrhunskim naučnicima iz zemalja EU rezultirala je i zajedničkim radovima, te partnerstvom u značajnim projektima. U svojim istraživanjima, LMB uspešno sarađuje sa eminentnim zdravstvenim ustanovama u Srbiji i zemljama Balkana, a stečeno znanje se primenjuje za stalno unapređenje medicinske prakse uvođenjem molekularno genetičke dijagnoze genetičkih poremećaja i maligniteta. Za mnoga genetička testiranja, LMB je jedinstveno mesto na Balkanu. Tim LMB aktivno učestvuje u obrazovanju mladih kadrova u okviru Univerziteta u Beogradu, naročito u procesu izrade multidisciplinarnih doktorskih teza. Takođe, popularizacija i promocija molekularne genetike, genomike i biomedicine na svim nivoima je stalna aktivnost istraživača Laboratorije za molekularnu biomedicinu.

Tekući projekti
Odabrane publikacije
  • Viennas E, Komianou A, Mizzi C, Stojiljkovic M, Mitropoulou C, Muilu J, Vihinen M, Grypioti P, Papadaki S, Pavlidis C, Zukic B, Katsila T, van der Spek PJ, Pavlovic S, Tzimas G, Patrinos GP. Expanded national database collection and data coverage in the FINDbase worldwide database for clinically relevant genomic variation allele frequencies. Nucleic Acids Res. 2017;45(D1):D846-D853
  • Dragasevic S, Stankovic B, Milosavljevic T, Sokic-Milutinovic A, Lukic S, Alempijevic T, Zukic B, Kotur N, Nikcevic G, Pavlovic S, Popovic D. Genetic and environmental factors significant for the presentation and development of inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2017;29(8):909-915.
  • Skakic A, Djordjevic M, Sarajlija A, Klaassen K, Tosic N, Kecman B, Ugrin M, Spasovski V, Pavlovic S, Stojiljkovic M. Genetic characterization of GSD I in Serbian population revealed unexpectedly high incidence of GSD Ib and three novel SLC37A4 variants. Clin Genet. 2017 Jul 7. doi: 10.1111/cge.13093.
  • Bojović K, Stanković B, Kotur N, Krstić-Milošević D, Gašić V, Pavlović S, Zukić B, Ignjatović Đ. Genetic predictors of celiac disease, lactose intolerance, and vitamin D function and presence of peptide morphins in urine of children with neurodevelopmental disorders. Nutr Neurosci. 2017 Jul 24:1-11. doi: 10.1080/1028415X.2017.1352121.
  • Pavlović S, Stojiljković M, Tošić N, Zukić B, Ugrin M, Karan-Djurašević T, Spasovski V. Genomics as a basis for precision medicine. Biologia Serbica. 2017;39(1):46-52.
  • Todorovic Balint M, Jelicic J, Mihaljevic B, Kostic J, Stanic B, Balint B, Pejanovic N, Lucic B, Tosic N, Marjanovic I, Stojiljkovic M, Karan-Djurasevic T, Perisic O, Rakocevic G, Popovic M, Raicevic S, Bila J, Antic D, Andjelic B, Pavlovic S. Gene Mutation Profiles in Primary Diffuse Large B Cell Lymphoma of Central Nervous System: Next Generation Sequencing Analyses. Int J Mol Sci. 2016;17(5):683.
  • Mizzi C, Dalabira E, Kumuthini J, Dzimiri N, Balogh I, Başak N, Böhm R, Borg J, Borgiani P, Bozina N, Bruckmueller H, Burzynska B, Carracedo A, Cascorbi I, Deltas C, Dolzan V, Fenech A, Grech G, Kasiulevicius V, Kádaši Ľ, Kučinskas V, Khusnutdinova E, Loukas YL, Macek M Jr, Makukh H, Mathijssen R, Mitropoulos K, Mitropoulou C, Novelli G, Papantoni I, Pavlovic S, Saglio G, Setric J, Stojiljkovic M, Stubbs AP, Squassina A, Torres M, Turnovec M, van Schaik RH, Voskarides K, Wakil SM, Werk A, Del Zompo M, Zukic B, Katsila T, Lee MT, Motsinger-Rief A, Mc Leod HL, van der Spek PJ, Patrinos GP. A European spectrum of pharmacogenomic biomarkers: Implications for clinical pharmacogenomics. PLoS One. 2016;11(9):e0162866.
  • Marjanovic I, Kostic J, Stanic B, Pejanovic N, Lucic B, Karan-Djurasevic T, Janic D, Dokmanovic L, Jankovic S, Vukovic NS, Tomin D, Perisic O, Rakocevic G, Popovic M, Pavlovic S, Tosic N. Parallel targeted next generation sequencing of childhood and adult acute myeloid leukemia patients reveals uniform genomic profile of the disease. Tumour Biol. 2016;37(10):13391-13401.
  • Paschou P, Drineas P, Yannaki E, Razou A, Kanaki K, Tsetsos F, Padmanabhuni SS, Michalodimitrakis M, Renda MC, Pavlovic S, Anagnostopoulos A, Stamatoyannopoulos JA, Kidd KK, Stamatoyannopoulos G. Maritime route of colonization of Europe. Proc Natl Acad Sci U S A. 2014;111(25):9211-6
  • Giardine B, Borg J, Higgs D, Peterson K, Philipsen S, Maglott D, Singleton B, Anstee D, Basak AN, Clark B, Costa F, Faustino P, Fedosyuk H, Felice A, Francina A, Galanello R, Gallivan M, Georgitsi M, Gibbons R, Giordano P, Harteveld C, Hoyer J, Jarvis M, Joly P, Kanavakis E, Kollia P, Menzel S, Miller W, Moradkhani K, Old J, Papachatzopoulou A, Papadakis M, Papadopoulos P, Pavlovic S, Perseu L, Radmilovic M, Riemer C, Satta S, Schrijver I, Stojiljkovic M, Thein SL, Traeger-Synodinos J, Tully R, Wada T, Waye J, Wiemann C, Zukic B, Chui D, Wajcman H, Hardison R, Patrinos P. Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach. Nat Genet 2011:43(4):295-301.
Kontakt

Vojvode Stepe 444a
Poštanski fah 23
11010 Beograd, Srbija

Tel: +381 11 3976445
Faks: +381 11 3975808

zmzg@imgge.bg.ac.rs 

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