Laboratorija za molekularnu biologiju

 

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Istraživanje

U Laboratoriji za molekularnu biologiju se izučavaju molekularni mehanizmi koji leže u osnovi kardovaskularnih, malignih, plućnih i neuromišićnih bolesti. Naši istraživački ciljevi obuhvataju rasvetljavanje fundamentalnih fiziloških procesa i etiopatoloških mehanizama u ovim bolestima, kao i primenu dobijenih rezultata u dijagnostici i terapiji. Oblasti istraživanja laboratorije su:

  • Ispitivanje molekularnih mehanizama hemostaze, inflamacije, remodelovanja tkiva i  odgovora na mehanički i oksidativni stres.
  • Izučavanje biološke funkcije odabranih molekula i njihove uloge u oboljenjima od interesa: MARP proteini, protrombin, alfa 1-antitripsin, TGFB1, SMAD4, CYP2C19 i VKORC1.
  • Analiza uticaja genskih varijanti i sredinskih faktora na fenotip.
  • Identifikacija i funkcionalna karakterizacija molekularnih markera.
  • Farmakogenetika.
  • Proučavanje molekularnih mehanizama fizioloških i patoloških procesa od interesa in vitro (primarne i kontinuirane ćelijske linije) i in vivo (zebrice).
  • Razvoj metoda za neinvazivnu molekularnu dijagnostiku.

Laboratorija za molekularnu biologiju uspešno sarađuje sa brojnim naučno-istraživačkim i zdravstvenim ustanovama u Srbiji, kao i eminentnim institutima iz inostranstva i otvorena je za sve vidove saradnje.

Tekući projekti
Odabrane publikacije
  • Boskovic S, Marín-Juez R, Jasnic J, Reischauer S, El Sammak H, Kojic A, Faulkner G, Radojkovic D, Stainier DYR, Kojic S. Characterization of zebrafish (Danio rerio) muscle ankyrin repeat proteins reveals their conserved response to endurance exercise. PlosOne. 2018. DOI: 10.1371/journal.pone.0204312
  • Dragicevic S, Kosnik M, Divac Rankov A, Rijavec M, Milosevic K, Korosec P, Skerbinjek Kavalar M, Nikolic A. The Variants in the 3' Untranslated Region of the Matrix Metalloproteinase 9 Gene as Modulators of Treatment Outcome in Children with Asthma. Lung. 2018;196(3):297-303.
  • Novkovic M, Matic D, Kusic-Tisma J, Antonijevic N, Radojkovic D, Rakicevic L. Analysis of CYP2C19 genotype associated with bleeding in Serbian STEMI-patients undergone primary PCI and treated with clopidogrel. Eur J Clin Pharmacol. 2018;74(4):443-451.
  • Rakicevic L, Nestorovic A. Pharmacogenetics of Clopidogrel Therapy and Neurointerventional Procedures: We Need Precision Data for Precision Medicine. Clin Pharmacol Ther. 2018 Jun 19. doi: 10.1002/cpt.1105.
  • Divac Rankov A, Ljujić M, Petrić M, Radojković D, Pešić M, Dinić J. Targeting autophagy to modulate cell survival: a comparative analysis in cancer, normal and embryonic cells. Histochem Cell Biol. 2017;148(5):529-544.
  • Djordjevic V, Kovac M, Miljic P, Murata M, Takagi A, Pruner I, Francuski D, Kojima T, Radojkovic D. A novel prothrombin mutation in two families with prominent thrombophilia--the first cases of antithrombin resistance in a Caucasian population. J Thromb Haemost. 2013;11(10):1936-1939.
  • Miljic P, Gvozdenov M, Takagi Y, Takagi A, Pruner I, Dragojevic M, Tomic B, Bodrozic J, Kojima T, Radojkovic D, Djordjevic V. Clinical and biochemical characterization of the Prothrombin Belgrade mutation in a large Serbian pedigree: new insights into antithrombin resistance mechanism. J Thromb Haemost. 2017;15(4):670-677.
  • Supic G, Zeljic K, Rankov AD, Kozomara R, Nikolic A, Radojkovic D, Magic Z. miR-183 and miR-21 expression as biomarkers of progression and survival in tongue carcinoma patients. Clin Oral Investig 2017 Jun 14. doi: 10.1007/s00784-017-2126-y.
  • Jasnic-Savovic J, Krause S, Savic S, Kojic A, Kovcic V, Boskovic S, Nestorovic A, Rakicevic L, Schreiber-Katz O, Vogel JG, Schoser BG, Walter MC, Valle G, Radojkovic D, Faulkner G, Kojic S. Differential expression and localization of Ankrd2 isoforms in human skeletal and cardiac muscles. Histochem Cell Biol. 2016;146(5):569-584.
  • Nikolic A, Ristanovic M, Zivaljevic V, Rankov AD, Radojkovic D, Paunovic I. SMAD4 gene promoter mutations in patients with thyroid tumors. Exp Mol Pathol. 2015;99(1):100-103.
Kontakt

Vojvode Stepe 444a
Poštanski fah 23
11010 Beograd, Srbija

Tel: +381 11 3976658
Faks: +381 11 3975808

labmolbio@imgge.bg.ac.rs

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