Isidora Petrović

Naučni saradnik
Laboratorija za humanu molekularnu genetiku

Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI),
Univerzitet u Beogradu,

V. Stepe 444a,11010 Beograd, Srbija
Mob:   +381 65 39760212
Tel:     +381 11 3976212
Fax:    +381 11 3975808
E-mail: isidorapetrovic@imgge.bg.ac.rs

OBRAZOVANJE

2012 - Doktor bioloških nauka, Biološki fakultet (BF), Univerzitet u Beogradu (UB),
("Transkripciona regulacija ekspresije humanog SOX18 gena")
2005 - Magistar bioloških nauka, BF, UB
2000 - Diplomirani molekularni biolog i fiziolog, BF, UB

ISTRAŽIVAČKO ISKUSTVO

2013 - naučni saradnik, IMGGI, UB
2005 - 2013 - istraživač saradnik, IMGGI, UB
2001 - 2005 - istraživač pripravnik, IMGGI, UB           

OBLAST NAUČNOG INTERESOVANJA

Osnovna oblast naučno-istraživačkog rada je ispitivanje molekularnih mehanizama koji leže u osnovi razvoja malignih tumora i njihovog širenja, sa posebnim osvrtom na ulogu SOX gena u ovim procesima. Cilj je pronalaženje novih dijagnostičkih/prognostičkih markera kao i potencijalnih ciljnih gena/proteina za razvoj novih terapeutskih pristupa. Pored toga, istraživanja su usmerena u pravcu analize novih prirodnih i sintetičkih agenasa koji imaju antitumorsko dejstvo. Ova ispitivanja se vrše in vitro na različitim karcinomskim ćelijskim linijama, kao i in vivo na modelu zebra ribica.

ODABRANI NAUČNI RADOVI

Dimić DS, Marković ZS, Saso L, Avdović EH, Đorović JR, Petrović IP, Stanisavljević DD, Stevanović MJ, Potočňák I, Samoľová E, Trifunović SR, Dimitrić Marković JM. Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent. Oxid Med Cell Longev. 2019 Feb 13;2019:2069250. https://www.ncbi.nlm.nih.gov/pubmed/30906500

Tosic N, Petrovic I, Grujicic NK, Davidovic S, Virijevic M, Vukovic NS, Pavlovic S, Stevanovic M. Prognostic significance of SOX2, SOX3, SOX11, SOX14 and SOX18 gene expression in adult de novo acute myeloid leukemia. Leuk Res. 2018 Apr;67:32-38. https://www.ncbi.nlm.nih.gov/pubmed/29428447

Smiljkovic M, Stanisavljevic D, Stojkovic D, Petrovic I, Marjanovic Vicentic J, Popovic J, Golic Grdadolnik S, Markovic D, Sankovic-Babice S, Glamoclija J, Stevanovic M, Sokovic M.Apigenin-7-O-glucoside versus apigenin: Insight into the modes of anticandidal and cytotoxic actions. EXCLI J. 2017 May 23;16:795-807. doi: 10.17179/excli2017-300. eCollection 2017.
https://www.ncbi.nlm.nih.gov/pubmed/28827996 

Dejan S. Stojkovic , Natasa Kovacevic-Grujici, Filipa S. Reis, Slobodan Davidovic , Lillian Barrosc, Jelena Popovi, Isidora Petrovic, Aleksandar Pavic, Jasmina Glamoclija, Ana Ciric, Milena Stevanovic, Isabel C.F.R. Ferreira, Marina Sokovic . Chemical composition of the mushroom Meripilus giganteus Karst. and bioactive properties of its methanolic extract, LWT - Food Science and TechnologyVolume 79, June 2017, Pages 454-462 http://dx.doi.org/10.1016/j.lwt.2017.01.045

Stanisavljevic D, Petrovic I, Vukovic V, Schwirtlich M, Gredic M, Stevanovic M, Popovic J. SOX14 activates the p53 signaling pathway and induces apoptosis in a cervical carcinoma cell line. PLoS One. 2017 Sep 19;12(9):e0184686. doi: 10.1371/journal.pone.0184686. eCollection 2017. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604970/

Petrovic I, Milivojevic M, Popovic J, Schwirtlich M, Rankovic B, Stevanovic M. SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines. PLoS One. 2015 Nov20;10(11):e0143591. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654472/pdf/pone.0143591.pdf

Kovacevic-Grujicic N, Mojsin M, Popovic J, Petrovic I, Topalovic V, Stevanovic M. Cyclic AMP response element binding (CREB) protein acts as a positive regulator of SOX3 gene expression in NT2/D1 cells. BMB Rep. 2014 Apr;47(4):197-202. http://www.ncbi.nlm.nih.gov/pubmed/24257117

Milivojevic M, Petrovic I, Kovacevic-Grujicic N, Popovic J, Mojsin M, Stevanovic M. Construction and functional analysis of novel dominant-negative mutant of human SOX18 protein. Biochemistry (Mosc). 2013 Nov;78(11):1287-92. doi: 10.1134/S0006297913110096. http://www.ncbi.nlm.nih.gov/pubmed/24460943

Petrovic I, Kovacevic-Grujicic N, Stevanovic M Early growth response protein 1 acts as an activator of SOX18 promoter. Exp Mol Med. 2010 Feb 28;42(2):132-42. doi: 10.3858/emm.2010.42.2.015. http://www.ncbi.nlm.nih.gov/pubmed/20054233

Popović J., Klajn A., Petrović I., Stevanović M. Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression. 2010. Biochim Biophys Acta- Gene Reg Mech 1799(5-6):411-418. doi: 10.1016/j.bbagrm.2010.01.002. Epub 2010 Jan 13. http://www.ncbi.nlm.nih.gov/pubmed/20074681

Petrovic I, Kovacevic-Grujicic N, Stevanovic M. ZBP-89 and Sp3 down-regulate while NF-Y up-regulates SOX18 promoter activity in HeLa cells. Mol Biol Rep. 2009 May;36(5):993-1000. doi: 10.1007/s11033-008-9272-x. Epub 2008 May 22. http://www.ncbi.nlm.nih.gov/pubmed/18496767

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