Gordana Nikčević

Naučni savetnik
Laboratorija za molekularnu biomedicinu

Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI),
Univerzitet u Beogradu,

Vojvode Stepe 444a, 11042 Beograd 152, Srbija
Mob:   +381 65 397 64 45
Tel:     +381 11 397 64 45
Fax: +381 11 397 58 08
E-mail: gordnik@imgge.bg.ac.rsgordnik7@gmail.com                                  

OBRAZOVANJE

1998 - Doktor bioloških nauka, Biološki fakultet (BF), Univerzitet u Beogradu (UB),
(naslov teze: "Uticaj ekspresije katalitičkog domena kinaze lakog lanca miozina na kontraktilna svojstva ne-mišićnih ćelija")
1988 - Magistar bioloških nauka, BF, UB
1984 - Diplomirani biolog, BF, UB

ISTRAŽIVAČKO ISKUSTVO

2016 - naučni savetnik, IMGGI, UB
2006 - 2016 - viši naučni saradnik, IMGGI, UB
2000 - 2006 - naučni saradnik, IMGGI, UB
1993 - 2000 - gostujući istraživač, University of Illinois at Chicago, SAD
1988 - 1993 - istraživač saradnik, IMGGI
1986 - 1988 - istraživač pripravnik, Centar za genetičko inženjerstvo, Beograd

RADNO ISKUSTVO

2014 - 2018 predavač na doktorskim studijama na Biološkom fakultetu (BF), UB, u okviru studijskog programa: Personalizovana medicina i farmakogenomika
2008 - 2020 predavač na doktorskim studijama na BF, UB, u okviru studijskog programa: Metodološki pristupi u molekularnoj biologiji
2007 - predavač na doktorskim studijama na BF, UB, u okviru studijskog programa: Molekularna biologija gena
2001 - 2006 - zamenik direktora IMGGI, UB

OSTALE AKTIVNOSTI   

2017 - Član Matičnog naučnog odbora za biologiju, Ministarstvo prosvete, nauke i tehnološkog razvoja, Republika Srbija
2013 - 2017 predsednik Naučnog veća IMGGI, UB
2010 - zamenik predsednika Upravnog odbora IMGGI, UB

ODABRANI PROJEKTI 

Unapređenje istraživačkog potencijala IMGGI kroz napredak biomedicinske nauke o retkim bolestima u Srbiji - put ka inovacijama „SERBORDISinn”, (EU FP7-REGPOT-2012-2013-1), 316088, Evropska komisija, 2013-2016. Naučni koordinator/pomoćnik koordinatora

Evropska mreža za istraživanje gena u sindromu iritabilnog kolona „GENIEUR” - COST akcija BM1106, Evropska komisija, 2012-2016. Zamenik predstavnika Republike Srbije u menadžment komitetu

OBLAST NAUČNOG INTERESOVANJA

Izučavanje molekularnih mehanizama uključenih u regulaciju ekspresije odabranih eukariotskih gena. Istraživanje molekularne osnove različitih retkih bolesti, analiza genetičkih polimorfizama koji su značajni za optimizaciju farmako-terapije inflamatornih bolesti. Primena animalnih mezenhimalnih matičnih ćelija adipoznog tkiva u regenerativnoj medicini i tkivnom inženjerstvu. Izučavanje pristupa za povećanje terapeutskog kapaciteta ovih ćelija genetičkim modifikacijama - eksprimiranjem specifičnih transgena čiji produkti bi pospešili remodelovanje koštanog i hrskavičavog tkiva.

ODABRANI NAUČNI RADOVI

  1. Nikcevic G, Srzentic Drazilov S, Karan Djurasevic T, Tosic N, Christos K. Kontos, Andreas Scorilas and Pavlovic S. Complex transcriptional regulation of the BCL2L12 gene: Novel, active promoter in K562 cells. Gene 2020, 750: 144723. https://pubmed.ncbi.nlm.nih.gov/32387119/
  1. Stankovic B, Dragasevic S, Klaassen K, Kotur N, Srzentic Drazilov S, Zukic B, Sokic Milutinovic A, Milovanovic T, Lukic S, Popovic D, Pavlovic S, Nikcevic G. Exploring inflammatory and apoptotic signatures in distinct Crohn's disease phenotypes: Way towards molecular stratification of patients and targeted therapy. Pathol Res Pract 2020, 216: 152945. https://pubmed.ncbi.nlm.nih.gov/32279918/
  1. Srzentić Dražilov S, Mrkovački J, Spasovski V, Fazlagić A, Pavlović S, Nikčević G. The use of canine mesenchymal stem cells for the autologous treatment of osteoarthritis. Acta Vet Hung 2018, 66: 376-389. https://pubmed.ncbi.nlm.nih.gov/30264620/
  1. Dragasevic S, Stankovic B, Milosavljevic T, Sokic-Milutinovic A, Lukic S, Alempijevic T, Zukic B, Kotur N, Nikcevic G, Pavlovic S, Popovic D. Genetic and environmental factors significant for the presentation and development of inflammatory bowel disease. Eur J Gastroenterol Hepatol 2017, 29: 909-915. https://pubmed.ncbi.nlm.nih.gov/28452812/
  1. Gazouli M, Wouters MM, Kapur-Pojskić L, Bengtson MB, Friedman E, Nikčević G, Demetriou CA, Mulak A, Santos J, Niesler B. Lessons learned - resolving the enigma of genetic factors in IBS. Nat Rev Gastroenterol Hepatol 2016, 13: 77-87. https://pubmed.ncbi.nlm.nih.gov/26726033/
  1. Jasnic-Savovic J, Klajn A, Milivojevic M, Mojsin M, Nikcevic G. Human Embryonal Carcinoma Cells in Serum-free Conditions as an In Vitro Model System of Neural Differentiation. Altern Lab Anim 2015, 43: 9-18. https://pubmed.ncbi.nlm.nih.gov/25802994/
  1. Srzentić S, Nikčević G, Spasovski D, Baščarević Z, Živković Z, Terzic-Šupić Z, Matanović D, Djordjević V, Pavlović S, Spasovski V. Predictive genetic markers of coagulation, inflammation and apoptosis in Perthes disease-Serbian experience. Eur J of Pediatr 2015, 174: 1085-1092. https://pubmed.ncbi.nlm.nih.gov/25754626/
  1. Spasovski V, Tosic N, Nikcevic G, Stojiljkovic M, Zukic B, Radmilovic M, Karan – Djurasevic T, Srzentic S, Colovic M, Pavlovic S. The influence of novel transcriptional regulatory element in intron 14 on expression of Janus kinase 2 gene in myeloproliferative neoplasms. J Appl Genet 2013, 54: 21-26. http://www.ncbi.nlm.nih.gov/pubmed/23188718
  1. Kotur N, Stankovic B, Kassela K, Georgitsi M, Vicha A, Dokmanovic L, Janic D, Krstovski N, Klaassen K, Radmilovic M, Stojiljkovic M, Nikcevic G, Simeonidis A, Sivolapenko G, Pavlovic S, Patrinos GP, Zukic B. Six-mercaptopurine influences TPMT gene transcription in a TPMT gene promoter variable number of tandem repeats-dependent manner. Pharmacogenomics 2012, 13: 283-295. http://www.ncbi.nlm.nih.gov/pubmed/22304581
  1. Nikčević G., Kovačević-Grujičić N., Mojsin M., Krstić A., Savić T., and Stevanović M. Regulation of the SOX3 Gene Expression by Retinoid Receptors. Physiol Res 2011, 60: S83-S91. https://pubmed.ncbi.nlm.nih.gov/21777018/
  1. Stojiljkovic M., Zukic B., Tosic N., Karan-Djurasevic T., Spasovski V., Nikcevic G. and Pavlovic S. Novel transcriptional regulatory element in the phenylalanine hydroxylase gene intron Mol Genet Metab 2010, 101: 81-83. http://www.ncbi.nlm.nih.gov/pubmed/20599406
  1. Nikčević G, Savić T, Kovačević-Grujičić N. and Stevanović M, Up-regulation of the SOX3 gene expression by retinoic acid: characterization of the novel promoter-response element and the retinoid receptors involved. J Neurochem 2008, 107: 1206-1215. http://www.ncbi.nlm.nih.gov/pubmed/18786169
  1. Mojsin M, Grujicic KN, Nikcevic G, Krstic A, Savic T, Stevanovic M. Mapping of the RXRalpha binding elements involved in retinoic acid induced transcriptional activation of the human SOX3 Neurosci Res 2006, 56: 409-418. http://www.ncbi.nlm.nih.gov/pubmed/17005281
  1. Nikčević, G., Kovačević-Grujičić, N. and Stevanović, M. Improved transfection efficiency of cultured human cells. Cell Biol Int 2003, 27: 735-737. http://www.ncbi.nlm.nih.gov/pubmed/12972278
  1. Nikčević, G., Perhonen, M., Boateng, S. and Russell, B. Translation is regulated via the 3’ untranslated region of a-myosin heavy chain mRNA by calcium but not by its localization. J Muscle Res Cell M 2000, 21: 599-607. http://www.ncbi.nlm.nih.gov/pubmed/11206137
  1. Nikčević, G., Heidkamp, M., Perhonen, M. and Russell, B. Mechanical activity in heart regulates translation of a-myosin heavy chain mRNA but not its localization. Am J Physiol-Heart Circ 1999, 276: H2013-H2019. http://www.ncbi.nlm.nih.gov/pubmed/10362682
  1. Hecht, G.A., Pestić, L., Nikčević, G., Koutsouris, A., Tripuraneni, J., Lorimer, D., Nowak, G., Guerriero, V., Elson, E. and de Lanerolle, P. Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability. Am J Physiol-Cell Physiol 1996, 271: C1678‑C1684 http://www.ncbi.nlm.nih.gov/pubmed/8944652
  1. Obara, K., Nikčević, G., Pestić, L., Nowak, G., Guerriero, V., Paul, R.J., Elson, E.L. and de Lanerolle, P. Fibroblast contractility without an increase in basal myosin light chain phosphorylation in wild type cells and cells expressing the catalytic domain of myosin light chain kinase. J Biol Chem 1995, 270: 18734‑18737 http://www.ncbi.nlm.nih.gov/pubmed/7642521
  1. Marjanović, J., Savković, S., Nikčević, G., Glišin, V., Ivanović, Z., Milenković, P. and Popović, Z. The disbalance of a‑ and b‑globins in anemic Belgrade rat red blood cells. Biochem Bioph Res Co 1994, 201: 115‑122. http://www.ncbi.nlm.nih.gov/pubmed/8198563
  1. Knežić, Z., Nikčević, G., Marjanović, J., Glišin, V. and Popović, Z. Constitutive interferon expression from retroviral vector. Antivir Res 1993, 22: 215‑221. http://www.ncbi.nlm.nih.gov/pubmed/8279813

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