Danijela Drakulić

Naučni saradnik
Laboratorija za humanu molekularnu genetiku

Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI),
Univerzitet u Beogradu,

V. Stepe 444a, 11010 Beograd, Srbija
Mob:   +381 65 397 62 12
Tel:     +381 11 397 62 12
Fax:    +381 11 397 58 08
E-mail: danijeladrakulic@imgge.bg.ac.rs                                   

OBRAZOVANJE

2011 - Doktor bioloških nauka, Biološki fakultet (BF), Univerzitet u Beogradu (UB),
(Analiza efekta povećane ekspresije SOX2 gena na održavanje pluripotentnosti, proliferaciju i neuralnu diferencijaciju embrionalnih karcinomskih NT2/D1 ćelija)
2005 - Magistar bioloških nauka, BF, UB
2000 - Diplomirani molekularni biolog i fiziolog, BF, UB

ISTRAŽIVAČKO ISKUSTVO

2012 - naučni saradnik, IMGGI, UB
2005 - 2012 - istraživač saradnik, IMGGI, UB
2002 - 2005 - istraživač pripravnik, Institut za molekularnu genetiku i genetičko inženjerstvo, (IMGGI), UB

RADNO ISKUSTVO

2012 - predavač na doktorskim studijama na Biološkom fakultetu, UB, u okviru studijskog programa Molekularna biologija (predmet Metodološki pristupi u molekularnoj biologiji)

OSTALE AKTIVNOSTI           

2017- član Management Committee-a COST akciji pod nazivom "Maximising Impact of research in Neuro-Developmental DisorderS (MINDDS)"
2017 - član Srpskog društva za molekularnu biologiju
2017 - član Društva genetičara Srbije
2013 – 2016 rukovodilac podprojekta WP3 u okviru FP7-REGPOT-2012-2013-1SERBORDISinn projekta “Strengthening the Research Potential of IMGGE through Reinforcement of Biomedical Science of Rare Diseases in Serbia – en route for innovation”- SERBORDISinn
2009 - Wellcome Trust Advanced Course: Genetic Manipulation of ES cells, Wellcome Trust Genome Campus, Hinxton, Cambridge, Velika Britanija, period: 20 oktobar - 8 novembar
2007 - Preimplantation Genetic Diagnosis Workshop, UCL centre, London,Velika Britanija, period: 16-20 april
2004 - University of Nottingham, Queen’s Medical Centre, Nottingham, Velika Britanija, period: septembar 2004. g – obuka za tehniku RNK-RNK in situ hibridizacija
2003 - Theoretical and Practical Course: Molecular Cytogenetics using fluorescent in situ hybridisation techniques, Sfax, Tunis, period: 4-12 april

OBLAST NAUČNOG INTERESOVANJA

Proučavanje efekata izmenjene ekspresije SOXB1 gena na pluripotentnost, proliferaciju, migraciju, neuralnu diferencijaciju i ćelijsku smrt embrionalnih karcinomskih i tumorskih ćelija
Uspostavljanje uslova i primena tehnike fluorescentne in situ hibridizacije u detekciji numeričkih i strukturnih aberacija hromozoma čoveka

ODABRANI NAUČNI RADOVI

Cuturilo G, Drakulic D, Jovanovic I, Ilic S, Kalanj J, Vulicevic I, Raus M, Skoric D, Mijovic M, Medjo B, Rsovac S, Stevanovic M. The Impact of 22q11.2 Microdeletion on Cardiac Surgery Postoperative Outcome. Pediatr Cardiol. 2017 38(8):1680-5. https://www.ncbi.nlm.nih.gov/pubmed/28940032

Marjanović Vićentić J, Schwirtlich M, Kovačević- Grujičić N, Stevanović M, Drakulić D. All-trans retinoic acid influences viability, migration and adhesion of U251 glioblastoma cells. Arch Biol Sci. 2017 69(4):699-706.   http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641700016M

Cuturilo G, Drakulic D, Jovanovic I, Krstic A, Djukic M, Skoric D, Mijovic M, Stefanovic I, Milivojevic M, Stevanovic M. Improving the Diagnosis of Children with 22q11.2 Deletion Syndrome: A Single-center Experience from Serbia. Indian Pediatr. 2016 53(9):786-9. https://www.ncbi.nlm.nih.gov/pubmed/27771646

Rakonjac M, Cuturilo G, Stevanovic M, Jelicic L, Subotic M, Jovanovic I, Drakulic D. Differences in speech and language abilities between children with 22q11.2 deletion syndrome and children with phenotypic features of 22q11.2 deletion syndrome but without microdeletion. Res Dev Disabil. 2016 55:322-9.  https://www.ncbi.nlm.nih.gov/pubmed/27235769

Rakonjac MCuturilo GStevanovic MJovanovic IDobrijevic Jelicic LJMijovic MDrakulic D. Speech and language abilities of children with the familial form of 22q11.2 deletion syndrome. GENETIKA-BELGRADE. 2016 48(1):57-72. http://www.dgsgenetika.org.rs/abstrakti/vol48no1rad6.pdf

Mojsin M, Topalovic V, Vicentic JM, Schwirtlich M, Stanisavljevic D, Drakulic D, Stevanovic M. Crosstalk between SOXB1 proteins and WNT/β-catenin signaling in NT2/D1 cells. Histochem Cell Biol. 2015 144(5):429-41. https://www.ncbi.nlm.nih.gov/pubmed/26239426

Drakulic D, Marjanovic Vicentic J, Schwirtlich M, Tosic J, Krstic A, Klajn A, Stevanovic M. The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1. An Acad Bras Cienc. 2015 87(1):389-404. https://www.ncbi.nlm.nih.gov/pubmed/25761220

Klajn A, Drakulic D, Tosic M, Pavkovic Z, Schwirtlich M, Stevanovic M. SOX2 overexpression affects neural differentiation of human pluripotent NT2/D1 cells. Biochemistry (Mosc). 2014 79(11):1172-82. https://www.ncbi.nlm.nih.gov/pubmed/25540002

Cuturilo G, Drakulic D, Krstic A, Gradinac M, Ilisic T, Parezanovic V, Milivojevic M, Stevanovic M, Jovanovic I. The role of modern imaging techniques in the diagnosis of malposition of the branch pulmonary arteries and possible association with microdeletion 22q11.2. Cardiol Young. 2013 23(2):181-8. https://www.ncbi.nlm.nih.gov/pubmed/22717372 

Drakulic D, Krstic A, Stevanovic M. Establishment and initial characterization of SOX2-overexpressing NT2/D1 cell clones. Genet Mol Res. 2012 11(2):1385-400.  https://www.ncbi.nlm.nih.gov/pubmed/22653585

Cuturilo G, Menten B, Krstic A, Drakulic D, Jovanovic I, Parezanovic V, Stevanovic M. 4q34.1-q35.2 deletion in a boy with phenotype resembling 22q11.2 deletion syndrome. Eur J Pediatr. 2011 170(11):1465-70. https://www.ncbi.nlm.nih.gov/pubmed/21833498 

Djordjević VA, Jovanović JV, Pavković-Lučić SB, Drakulić DD, Djurović MM, Gotić MD. Cytogenetic findings in Serbian patients with Turner's syndrome stigmata. Genet Mol Res. 2010 9(4):2213-21. https://www.ncbi.nlm.nih.gov/pubmed/21064029 

Jovicić D, Milacić S, Vukov TD, Rakić B, Stevanović M, Drakulić D, Rakić R, Bukvić N. Detection of premature segregation of centromeres in persons exposed to ionizing radiation. Health Phys. 2010 98(5):717-27. https://www.ncbi.nlm.nih.gov/pubmed/20386201

Milivojević M, Nikčević G, Kovačević-Grujičić N, Krstić A, Mojsin M, Drakulić D, Stevanović M. Involvement of ubiquitous and TALE transcription factors, as well as liganded RXR in the regulation of human SOX2 gene expression in NT2/D1 embryonal carcinoma cell line. Arch Biol Sci. 2010 62:199-210.

Djordjević V, Dencić-Fekete M, Jovanović J, Drakulić D, Stevanović M, Janković G, Gotić M. Pattern of trisomy 1q in hematological malignancies: a single institution experience. Cancer Genet Cytogenet. 2008 186(1):12-8. https://www.ncbi.nlm.nih.gov/pubmed/18786437

Cuturilo G, Drakulic D, Stevanovic M, Jovanovic I, Djukic M, Miletic-Grkovic S, Atanaskovic-Markovic M. A rare association of interrupted aortic arch type C and microdeletion 22q11.2. Eur J Pediatr. 2008 167(10):1195-8. https://www.ncbi.nlm.nih.gov/pubmed/18040716

Drakulić D, Nikčević G, Djordjević V, Stevanović M. Generation of a whole chromosome painting probe from monochromosomal hybrid cells by the Alu-polymerase chain reaction. Arch Biol Sci. 2007 59:89-95.

Mojsin M, Djurovic J, Petrovic I, Krstic A, Drakulic D, Savic T, Stevanovic M. Rapid detection and purification of sequence specific DNA binding proteins using magnetic separation. Journal of the Serbian Chemical Society. 2006 71:135-141.

Miljkovic Dj, Samardzic T, Drakulic D, Stosic-Grujicic S, Trajkovic V. Immunosuppressants leflunomide and mycophenolic acid inhibit fibroblast IL-6 production by distinct mechanisms. Cytokine. 2002 19(4):181-6. https://www.ncbi.nlm.nih.gov/pubmed/12297111

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