Detection of the NPM1 gene mutations

The presence of the mutations in the nucleophosmin gene (NPM1) is directly associated with the occurrence of leukemia. These mutations are specific for acute myeloid leukemia (AML), which represents the most common type of leukemia in adults.  Detection of the NPM1 mutations is important for the prognosis and for the monitoring of minimal residual disease. We use PCR methodology followed by direct sequencing.

It is necessary to deliver 4 to 5 ml of bone marrow or peripheral blood (depending on the disease phase) using 3.8% sodium citrate as anticoagulant in vol/vol ratio 9:1. The sample is required to be delivered fresh, without freezing, during the same day. The samples are accepted every day from 10 to 13h. It is possible to deliver the sample via post express service. The analysis is performed within 10 working days. The results and the bill are sent to the patient's home address, or can be collected personally at the Institute from 10 to 16h every day.

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  • Irena Marjanović
  • dr Nataša Tošić
  • dr Sonja Pavlović

Tel: +381 11 3976 445

Mob: +381 65 3976 445

Fax: +381 11 3975 808


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