Identification of sperm DNA fragmentation index (DFI index)

The genetic integrity of the spermatozoan is essential for normal embryo development. A high level of DNA fragmentation in sperm cells may represent a cause of male infertility that conventional examinations - sperm concentration, motility analysis, morphology assessment - cannot detect.  Results reported in the scientific literature have shown that regardless of the assisted reproductive technology used, an elevated level of DNA fragmentation above the critical threshold will significantly compromise the possibility of a successful pregnancy.

This test provides a reliable analysis of sperm DNA integrity that may help to identify men who are at risk of failing to initiate a healthy ongoing pregnancy. Information about sperm DNA integrity may help in the clinical diagnosis, management and treatment of male infertility and may be of prognostic value in assessing outcome of assisted conception treatment (IUI or IVF).

The samples are accepted only with prior scheduling. The analysis is also available for frozen sperm samples by prior arrangement with the hospital which offer sperm freezing. 


Contact: Jelena Popovic, PhD

Laboratory for Human Molecular Genetics

tel. +381 11 3976 212;

fax. +381 11 3975 808

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