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Unique bacterial collection encompassing lactic acid bacteria (LAB) isolated from traditional food products, LAB of human origin and clinicaly relevant and environmental microorganisms enables the up-to-date research in Laboratory for Molecular Microbiology (LMM) in the following areas:
I Beneficial microbes and their products against multi-drug resistant pathogens
- characterization and cloning of new antibiotic resistance genes;
- molecular basis of virulence factors;
- mechanisms involved in prevention of formation and/or biofilm degradation;
- new antimicrobial molecules (antibiotics, bacteriocins, secondary metabolites)
- characterization and application of adhesins - molecules that prevent pathogens binding;
- bacteriophages, as antibiotic replacament therapy.
II Host-microbe interactions
- LAB isolates as producers of bioactive compounds acting as immunomodulators, neurotransmitters or protectors in the host
- LAB probiotic potential in specific diseases and pathological conditions (IBD, diabetes, pain, multiple sclerosis, intoxications);
- enterococci: virulent vs. probiotic potential analysis;
- microbiota composition in correlation with autoimmune and neurodevelopmental diseases.
Innovative activities of LMM are focused on formulations of innovative probiotic and starter cultures for the production of functional food for humans and animals, as well as the formulations of new antimicrobial compounds as substitutes for antibiotics and food preservatives.
- Genes and Molecular Mechanisms Promoting Probiotic Activity of Lactic Acid Bacteria from Western Balkan
173019
Principal Investigator: Dr Milan Kojic, IMGGE - Molecular characterization of bacteria from genera Bacillus and Pseudomonas as potential agents for biological control
173026
Principal Investigator: Dr Djordje Fira, Faculty of Biology, University of Belgrade -
Development of new encapsulation and enzyme technology to produce biocatalysts and biologically active food components in order to increase its competitiveness, quality and safety
46010
Principal Investigator: Dr Branko Bugarski, Faculty of Technology and Metallurgy, University of Belgrade -
Development of technological processes for production of innovative probiotic products for prevention and treatment of intestinal infections in animals
Project 2616 of the Innovation Fund
Principal Investigator: Dr Natasa Golic, IMGGE -
Survey for antimicrobials effective against carbapenem-resistant Gram-negative bacteria
CRP/SRB15-02
Principal Investigator: Dr Branko Jovcic, Faculty of Biology, University of Belgrade -
Open Multiscale Systems Medicine (OpenMultiMed)
CA15120, 2016-2020
- Lozo J, Mirkovic N, O'Connor PM, Malesevic M, Miljkovic M, Polovic N, Jovcic B, Cotter PD, Kojic M. Lactolisterin BU, a Novel Class II Broad-Spectrum Bacteriocin from Lactococcus lactis subsp. lactis bv. diacetylactis BGBU1-4. Appl Environ Microbiol. 2017;83(21):pii:e01519-17.
- Filipic B, Malesevic M, Vasiljevic Z, Lukic J, Novovic K, Kojic M, Jovcic B. Uncovering Differences in Virulence Markers Associated with Achromobacter Species of CF and Non-CF Origin. Front Cell Infect Microbiol. 2017;7:224.
- Novović K, Trudić A, Brkić S, Vasiljević Z, Kojić M, Medić D, Ćirković I, Jovčić B. Molecular Epidemiology of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae in Serbia from 2013 to 2016. Antimicrob Agents Chemother. 2017;61(5):pii:e02550-16.
- Dinic M, Lukic J, Djokic J, Milenkovic M, Strahinic I, Golic N, Begovic J. Lactobacillus fermentum postbiotic-induced autophagy as potential approach for treatment of acetaminophen hepatotoxicity. Front Microbiol. 2017;8:594.
- Ljubobratovic U., Kosanovic D., Vukotic G., Molnar Z., Stanisavljevic N., Ristovic T., Peter G., Lukic J., Jeney G. Supplementation of lactobacilli improves growth, regulates microbiota composition and suppresses skeletal anomalies in juvenile pike-perch (Sander lucioperca) reared in recirculating aquaculture system (RAS): A pilot study. Res Vet Sci. 2017;115:451-462.
- Golić N, Veljović K, Popović N, Djokić J, Strahinić I, Mrvaljević I, Terzić-Vidojević A. 2017. In vitro and in vivo antagonistic activity of new probiotic culture against Clostridium difficile and Clostridium perfringens. BMC Microbiol. 2017;17:108.
- Veljovic K, Dinic M, Lukic J, Mihajlovic S, Tolinacki M, Zivkovic M, Begovic J, Mrvaljevic I, Golic N, Terzic-Vidojevic A. Promotion of early gut colonization by probiotic intervention on microbiota diversity in pregnant sows. Front Microbiol. 2017;8:2028.
- Stanisavljevic S., Lukic J., Sokovic S., Mihajlovic S., Mostarica Stojkovic M., Miljkovic Dj, Golic N. Correlation of gut microbiota composition with resistance to experimental autoimmune encephalomyelitis in rats. Front Microbiol. 2017;7: 2005.
- Miljkovic M, Uzelac G, Mirkovic N, Devescovi G, Diep DB, Venturi V, Kojic M. LsbB Bacteriocin Interacts with the Third Transmembrane Domain of the YvjB Receptor. Appl Environ Microbiol. 2016;82(17):5364-5374.
- Mirkovic N, Polovic N, Vukotic G, Jovcic B, Miljkovic M, Radulovic Z, Diep DB, Kojic M. Lactococcus lactis LMG2081 Produces Two Bacteriocins, a Nonlantibiotic and a Novel Lantibiotic. Appl Environ Microbiol. 2016; 82(8):2555-2562.
Vojvode Stepe 444a
Poštanski fah 23
11010 Beograd, Srbija
Tel: +381 11 3975960
Faks: +381 11 3975808