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Research
Unique bacterial collection encompassing lactic acid bacteria (LAB) isolated from traditional food products, LAB of human origin and clinicaly relevant and environmental microorganisms enables the up-to-date research in Laboratory for Molecular Microbiology (LMM) in the following areas:
I Beneficial microbes and their products against multi-drug resistant pathogens
- characterization and cloning of new antibiotic resistance genes;
- molecular basis of virulence factors;
- mechanisms involved in prevention of formation and/or biofilm degradation;
- new antimicrobial molecules (antibiotics, bacteriocins, secondary metabolites)
- characterization and application of adhesins - molecules that prevent pathogens binding;
- bacteriophages, as antibiotic replacament therapy.
II Host-microbe interactions
- LAB isolates as producers of bioactive compounds acting as immunomodulators, neurotransmitters or protectors in the host
- LAB probiotic potential in specific diseases and pathological conditions (IBD, diabetes, pain, multiple sclerosis, intoxications);
- enterococci: virulent vs. probiotic potential analysis;
- microbiota composition in correlation with autoimmune and neurodevelopmental diseases.
Innovative activities of LMM are focused on formulations of innovative probiotic and starter cultures for the production of functional food for humans and animals, as well as the formulations of new antimicrobial compounds as substitutes for antibiotics and food preservatives.
Current projects
- IMGGE work program for 2021
Ministry of Education, Science and Technological Development of the Republic of Serbia, 451-03-9/2021-14/200042, 2021
Principal Investigator: Dr Jelena Begovic, IMGGE
Participants from IMGGE: all employed researchers - Investigation of bacteriophages and phage-derived enzyme activity against biofilm-embedded cells of multidrug resistant Acinetobacter baumannii
Research project within scientific and technological cooperation between Republic of Italy and Republic of Serbia, 2019-2021
Principal Investigator: Dr Goran Vukotic, Faculty of Biology University of Belgrade
Participants from IMGGE: Dr Nemanja Stanisavljevic, Mina Obradovic, Milka Malesevic, Katarina Novovic, Dr Milan Kojic - PLASH - Probiotic lactobacilli as therapeutics for wound healing
Serbian Science and Diaspora Collaboration Program: Knowledge Exchange Vouchers, Science Fund of the Republic of Serbia, 6426409, 2020-2021
Principal Investigator: Dr Ivana Strahinic, IMGGE
Participant from IMGGE: Dr Miroslav Dinic - Nano-MDSC-Thera - Novel Immunotherapeutic Approaches for Autoimmune Diseases based on Myeloid Derived Suppressor Cells induced by Nanomaterials
Program for excellent projects of young researchers (PROMIS), Science Fund of the Republic of Serbia, 6062673, 2020-2022
Principal Investigator: Dr Sergej Tomic, Assistant Research Professor, Institute for Application of Nuclear Energy, University of Belgrade
Participants from IMGGE: Dr Jelena Djokic, Dusan Radojevic - ReTRA - Revitalization of traditional bread production procedures through innovative approaches
Program for excellent projects of young researchers (PROMIS), Science Fund of the Republic of Serbia, 6062634, 2020-2022
Principal Investigator: Dr Miroslav Hadnadjev, Associate Research Professor, Institute of Food Technology in Novi Sad, University of Novi Sad
Participant from IMGGE: Dr Nikola Popovic - LABLUNG - Mechanistic insight into the anti-inflammatory and antioxidative effects of lactic acid bacteria in in vitro models of chronic lung diseases
Program for excellent projects of young researchers (PROMIS), Science Fund of the Republic of Serbia, 6066974, 2020-2022
Principal Investigator: Dr Marija Stankovic, IMGGЕ
Participants from IMGGE: Dr Katarina Veljovic, dr Nikola Popovic, dr Natasa Golic - Novel biological agents for prevention and treatment of American foul brood infection in honey bee mini colonies
Proof of Concept, Innovation Fund of the Republic of Serbia, 5783, 2020-2021
Principal Investigator: Dr Nemanja Stanisavljevic
Participants from IMGGE: Dr Milan Kojic, dr Ivana Strahinic - Alleviation of lung inflammation by probiotics
Proof of Concept, Innovation Fund of the Republic of Serbia, 5709, 2020-2021
Principal Investigator: Dr Katarina Veljovic
Participants from IMGGE: Dr Svetlana Sokovic Bajic i Dr Natasa Golic -
Molecular mechanisms of lifespan extension induced by exopolysaccharide-producing lactobacilli in the Caenorhabditis elegans
Program "Pokreni se za nauku", Phillip Morris Company, 2020-2021
Principal Investigator: Dr Miroslav Dinic, IMGGE
Participants from IMGGE: Dr Jelena Djokic, Dr Svetlana Sokovic Bajic, Dusan Radojevic, Emilija Brdaric
Selected publications
- Pulmonary Aspergillus fumigatus infection in rats affects gastrointestinal homeostasis
Kulas J, Mirkov I, Tucovic D, Zolotarevski L, Glamoclija J, Veljovic K, Tolinacki M, Golic N, Kataranovski M
Immunobiology 2019;224(1):116-123 - The Influence of Heat-Killed Enterococcus faecium BGPAS1-3 on the Tight Junction Protein Expression and Immune Function in Differentiated Caco-2 Cells Infected With Listeria monocytogenes ATCC 19111
Popovic N, Djokic J, Brdaric E, Dinic M, Terzic-Vidojevic A, Golic N, Veljovic K
Front Microbiol 2019;10:412 - GABA-Producing Natural Dairy Isolate From Artisanal Zlatar Cheese Attenuates Gut Inflammation and Strengthens Gut Epithelial Barrier in vitro
Sokovic Bajic S, Djokic J, Dinic M, Veljovic K, Golic N, Mihajlovic S, Tolinacki M
Front Microbiol 2019;10:527 - Oral neonatal antibiotic treatment perturbs gut microbiota and aggravates central nervous system autoimmunity in Dark Agouti rats
Stanisavljević S, Čepić A, Bojić S, Veljović K, Mihajlović S, Đedović N, Jevtić B, Momčilović M, Lazarević M, Mostarica Stojković M, Miljković Đ, Golić N
Sci Rep 2019;9(1):918 - Acinetobacter spp. porin Omp33-36: Classification and transcriptional response to carbapenems and host cells
Novović K, Mihajlović S, Dinić M, Malešević M, Miljković M, Kojić M, Jovčić B
PLoS One 2018;13(8):e0201608 - Uncovering Differences in Virulence Markers Associated with Achromobacter Species of CF and Non-CF Origin
Filipic B, Malesevic M, Vasiljevic Z, Lukic J, Novovic K, Kojic M, Jovcic B
Front Cell Infect Microbiol 2017;7:224 - Lactolisterin BU, a Novel Class II Broad-Spectrum Bacteriocin from Lactococcus lactis subsp. lactis bv. diacetylactis BGBU1-4
Lozo J, Mirkovic N, O'Connor PM, Malesevic M, Miljkovic M, Polovic N, Jovcic B, Cotter PD, Kojic M
Appl Environ Microbiol 2017;83(21): e01519-17 - Probiotics or pro-healers: the role of beneficial bacteria in tissue repair
Lukic J, Chen V, Strahinic I, Begovic J, Lev-Tov H, Davis SC, Tomic-Canic M, Pastar I
Wound Repair Regen 2017;25(6):912-922 - Molecular Epidemiology of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae in Serbia from 2013 to 2016
Novović K, Trudić A, Brkić S, Vasiljević Z, Kojić M, Medić D, Ćirković I, Jovčić B
Antimicrob Agents Chemother 20174;61(5):e02550-16 - LsbB Bacteriocin Interacts with the Third Transmembrane Domain of the YvjB Receptor
Miljkovic M, Uzelac G, Mirkovic N, Devescovi G, Diep DB, Venturi V, Kojic M
Appl Environ Microbiol 2016;82(17):5364-5374
Contact
Head Office / Mailing address:
Vojvode Stepe 444a,
11042 Belgrade 152, Serbia
Tel: +381 11 3975960
Faks: +381 11 3975808