Nataša Golić

Research Associate

Institute of molecular genetics and genetic engineering (IMGGE),
University of Belgrade

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mobile: +381 64 8044096
Phone: +381 11 397 57 44
Fax:    +381 11 397 58 08
E-mail: natasag@imgge.bg.ac.rs

EDUCATION

2009 - PhD in Molecular Genetics and Genetic Engineering: “Analyses of the prt genes regulation in the natural isolate Lactococcus lactis subsp. lactis BGIS29”, Faculty of Biological Science, UB, Yugoslavia.
1996 - M.Sc. in Molecular Genetics and Genetic Engineering: “Cloning and analysis of the proteinase region of the natural isolate Lactococcus lactis subsp. lactis BGIS29”, Faculty of Biological Science, UB, Yugoslavia.
1993 - B.S. in Biology, Faculty of Natural Sciences, UB, Yugoslavia.

RESEARCH EXPERIENCE

2013 - Principal Research Fellow, Laboratory for Molecular Microbiology (LMM), IMGGE
2005-2012 - Senior Research Associate, Laboratory for Molecular Genetics of Industrial Microorganisms (LMGIM), IMGGE
2000-2005 - Research Associate, LMGIM, IMGGE
1996-2000 - Research Assistant, LMGIM, IMGGE
1994-1996 - Research Trainee, LMGIM, IMGGE

CAREER HISTORY

2015 - Co-founder of the Invetlab d.o.o., Institute first spin-off company;
2016 - Head of Sector for Technology Transfer;
2008 - Lecturer at PhD studies, Faculty of Pharmacy, UB
2008 - 2011 - Management representative of the quality management system in IMGGE
2007 - 2008 - Vice Director of IMGGE
2002 - 2006 - Lecturer on Postgraduate studies, Faculty of Biology, UB

RESEARCH INTEREST

Research interest includes: analysis of microbiota composition in correlation with various human and animal diseases, identification of new microbiological markers positively correlated with good health status of humans and animals, analysis of probiotic potential of natural isolates of bacteria, host-microbe interactions, biochemical characterization of bioactive compounds produced by probiotic bacteria. Current projects relate to the characterization of genes and factors responsible for the probiotic potential of lactobacilli (egzopolysaccharides, GABA, immunomodulators, neurotransmitters, autophagy induction). In addition, the development of new therapeutic strategies for the prevention and treatment of various diseases and formulations of probiotic cultures for humans and animals.

SELECTED PUBLICATIONS

  • Golić N, Veljović K, Popović N, Djokić J, Strahinić I, Mrvaljević I, Terzić-Vidojević A. 2017. In vitro and in vivo antagonistic activity of new probiotic culture against Clostridium difficile and Clostridium perfringens. BMC Microbiology 17:108.
  • Dinić M, Lukić J, Djokić J, Milenković M, Strahinić I, Golić N, Begović J. (2017) Lactobacillus fermentum postbiotic-induced autophagy as potential approach for treatment of acetaminophen hepatotoxicity. Front. Microbiol. 8: 594.
  • Stanisavljevic, S., Lukic, J., Sokovic, S., Mihajlovic, S., Mostarica Stojkovic, M., Miljkovic, D., Golic, N. (2016) Correlation of gut microbiota composition with resistance to experimental autoimmune encephalomyelitis in rats. Front. Microbiol. 7: 2005.
  • Živković M, Miljković M, Ruas-Madiedo P, Markelić M, Veljović K, Tolinački M, Soković S, Korać A, Golić N. (2016) EPS-SJ exopolisaccharide produced by the strain Lactobacillus paracasei subsp. paracasei BGSJ2-8 is involved in adhesion to epithelial intestinal cells and decrease on E. coli association to Caco-2 cells. Frontiers in Microbiology. 7: 286.
  • Rajilić-Stojanović, M., Jonkers, D. M., Salonen, A., Hanevik, K., Raes, J., Jalanka, J., de Vos, W. M., Manichanh, C., Golic, N., Enck, P., Philippou, E., Iraqi, F. A., Clarke, G., Spiller, R. C., Penders, J. Intestinal microbiota and diet in IBS: causes, consequences or epiphenomena. Am. J. Gastroenterol. (2015) 110(2):278-87.
  • Zivkovic M, Hidalgo-Cantabrana C, Kojic M, Gueimonde M, Golic N, Ruas-Madiedo P. Capability of exopolysaccharide-producing Lactobacillus paraplantarum BGCG11 and its non-producing isogenic strain NB1, to counteract the effect of enteropathogens upon the epithelial cell line HT29-MTX. Food Research International 74 (2015) 199–207.
  • Zivkovic M, Miljkovic M, Ruas-Madiedo P, Strahinic I, Tolinacki M, Golic N, Kojic M. Exopolysaccharide production and ropy phenotype are determined by two gene clusters in putative probiotic strain Lactobacillus paraplantarum BGCG11. Appl Environ Microbiol. (2015) 81(4):1387-96.
  • Terzic-Vidojevic A, Veljovic K, Begovic J, Filipic B, Popovic D, Tolinacki M, Miljkovic M, Kojic M and Golic N (2015) Diversity and antibiotic susceptibility of autochthonous dairy enterococci isolates: are they safe candidates for autochthonous starter cultures? Front. Microbiol.6:954.
  • Golic, N., Čadež, N., Terzic-Vidojevic, A.,  Šuranská, H., Beganović, J., Lozo, J.,  Kos, B., Šušković, J., Raspor, P., Topisirović, L.: Evaluation of microbial diversity in traditional white-pickled and fresh soft cheeses from mountain regions in Serbia and low laying regions in Croatia. Int. J. Food Microbiol. 166 (2013) 294-300.
  • Lukic, J., Strahinic, I., Milenkovic, M., Golic, N., Kojic, M., Topisirovic, L., Begovic, J.: Interaction of Lactobacillus fermentum BGHI14 with rat colonic mucosa – implications for colitis induction. Appl. Environ. Microbiol. 79 (2013) (18):5735-44.
  • Nikolic, M., López, P., Strahinic, I., Suárez, A., Kojic, M., Fernández-García, M., Topisirovic, L., Golic, N., Ruas-Madiedo, P.: Characterisation of the exopolysaccharide (EPS)-producing Lactobacillus paraplantarum BGCG11 and its non-EPS producing derivative strains as potential probiotics. Int J. Food Microbiol. 158 (2012) 155-162.
  • Kozoderović, G., Velhner, M., Jelesić, Z., Golić, N., Lozo, J., Kehrenberg, C.: Prevalence of quinolone resistance and mutations in the topoisomerase genes in Salmonella Enteritidis isolates from Serbia Int. J. Antimicrob. Agents. 40 (2012) (5) 455-457.
  • Strahinic, I., Busarcevic, M., Pavlica, D., Milasin, J., Golic, N., Topisirovic, L.: Molecular and biochemical characterization of human oral lactobacilli as putative probiotic candidates. Oral Microbiol. Immunol., 22 (2007) 111-117.
  • Topisirovic, L., Kojic, M., Fira, D., Golic, N., Strahinic, I., Lozo J.: Potential of lactic acid bacteria isolated from specific natural niches in food production and preservation. Int. J. Food Microbiol., 112 (2006) 230-235.
  • van Kranenburg, R., Golic, N., Bongers, R., Leer, R.J., de Vos, W.M., Siezen, R.J., Kleerebezem, M.: Functional analysis of three plasmids from Lactobacillus plantarum. Appl. Environ. Microbiol., 71 (2005) 1223-1230.    
  • Golic, N., Schliekelmann, M., Fernández, M., Kleerebezem, M., van Kranenburg, R.: Molecular characterization of the CmbR activator-binding site in the metC-cysK promoter region in Lactococcus lactis. Microbiol., (UK) 151 (2005) 439-446.

INVITED LECTURES

  • Golic, N. Host microbe crosstalk in the human gut. (2014) COST GENIEUR Training School “Assessment of IBS in Clinical Practice & Research: An Introduction for Scientists”, Barcelona, Spain.
  • Golic, N. Genetics of microorganisms. Detection and determination of microorganisms. 6th Congress of medical microbiology, Mikromed 2008. Invited lecture. Book of abstracts. 247, Belgrade, Serbia (2008).
  • Golic, N., Strahinic, I., Begovic, J., Tolinacki, M., Nikolic, M., Kojic, M., Beganovic, J., Kos, B., Cadez, N., Suskovic, J., Raspor, P., Topisirovic, L. Molecular diversity among lactic acid bacteria isolated from traditional cheeses manufactured in Western Balkan. 6th Central European Congress on Food (CEFood 2012) VII Traditional food, food with appellation of origin, Keynote lecture, VII O 009, Book of Abstracts, p. 481, Novi Sad, Serbia (2012).
  • Golić, N., Nikolić, M., Lukić, J., Filipić, B., Miljković, M., Tolinački, M., Terzić-Vidojević, A., Begović, J., Strahinić, I., Kojić, M. (2013) The role of microbes in immunomodulation, Invited lecture, Book of abstracts ISBN 978-86-914897-1-7, IX Congress of microbiologists of Serbia, Belgrade, Serbia.
  • Golić, N. Nikolić, M., Lukić, J., Miljković, M., Filipić, B., Dinić, M., Vukotić G., and Kojić M. Molecular mechanisms involved in health promoting potential of lactic acid bacteria. 2014. Round table, V CONGRESS OF THE SERBIAN GENETIC SOCIETY, Belgrade.

PATENTS

  • Golic N, Terzic-Vidojevic A, Veljovic K, Mrvaljevic I. "New probiotic starter cultures for human and animal use". Patent application submitted before Intellectual Property Office Republic of Serbia on 17.12.2015.

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