Laboratory for Molecular Microbiology

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Unique bacterial collection encompassing lactic acid bacteria (LAB) isolated from traditional food products, LAB of human origin and clinicaly relevant and environmental microorganisms enables the up-to-date research in Laboratory for Molecular Microbiology (LMM) in the following areas:

I Beneficial microbes and their products against multi-drug resistant pathogens

  • characterization and cloning of new antibiotic resistance genes;
  • molecular basis of virulence factors;
  • mechanisms involved in prevention of formation and/or  biofilm degradation;
  • new antimicrobial molecules (antibiotics, bacteriocins, secondary metabolites)
  • characterization and application of adhesins - molecules that prevent pathogens binding;
  • bacteriophages, as antibiotic replacament therapy.

II  Host-microbe interactions

  • LAB isolates as producers of bioactive compounds acting as immunomodulators, neurotransmitters or protectors in the host
  • LAB probiotic potential in specific diseases and pathological conditions (IBD, diabetes, pain, multiple sclerosis, intoxications);
  • enterococci: virulent vs. probiotic potential analysis;
  • microbiota composition in correlation with autoimmune and neurodevelopmental diseases.

Innovative activities of LMM are focused on formulations of innovative probiotic and starter cultures for the production of functional food for humans and animals, as well as the formulations of new antimicrobial compounds as substitutes for antibiotics and food preservatives.

Current projects
Selected publications
  • Dinić M, Pecikoza U, Djokić J, Stepanović-Petrović R, Milenković M, Stevanović M, Filipović N, Begović J, Golić N, Lukić J. Exopolysaccharide Produced by Probiotic Strain Lactobacillus paraplantarum BGCG11 Reduces Inflammatory Hyperalgesia in Rats. Front Pharmacol. 2018;9:1.
  • Popović N, Dinić M, Tolinački M, Mihajlović S, Terzić-Vidojević A, Bojić S, Djokić J, Golić N, Veljović K. New Insight into Biofilm Formation Ability, the Presence of Virulence Genes and Probiotic Potential of Enterococcus sp. Dairy Isolates. Front Microbiol. 2018;9:78.
  • Stanisavljević S, Dinić M, Jevtić B, Đedović N, Momčilović M, Đokić J, Golić N, Mostarica Stojković M, Miljković Đ. Gut Microbiota Confers Resistance of Albino Oxford Rats to the Induction of Experimental Autoimmune Encephalomyelitis. Front Immunol. 2018;9:942.
  • Vujicic M, Saksida T, Despotovic S, Bajic SS, Lalić I, Koprivica I, Gajic D, Golic N, Tolinacki M, Stojanovic I. The Role of Macrophage Migration Inhibitory Factor in the Function of Intestinal Barrier. Sci Rep. 2018;8(1):6337.
  • Lozo J, Mirkovic N, O'Connor PM, Malesevic M, Miljkovic M, Polovic N, Jovcic B, Cotter PD, Kojic M. Lactolisterin BU, a Novel Class II Broad-Spectrum Bacteriocin from Lactococcus lactis subsp. lactis bv. diacetylactis BGBU1-4. Appl Environ Microbiol. 2017;83(21):pii:e01519-17.
  • Lukic J, Chen V, Strahinic I, Begovic J, Lev-Tov H, Davis SC, Tomic-Canic M, Pastar I. Probiotics or pro-healers: the role of beneficial bacteria in tissue repair. Wound Repair Regen. 2017;25(6):912-922.
  • Filipic B, Malesevic M, Vasiljevic Z, Lukic J, Novovic K, Kojic M, Jovcic B. Uncovering Differences in Virulence Markers Associated with Achromobacter Species of CF and Non-CF Origin. Front Cell Infect Microbiol. 2017;7:224.
  • Novović K, Trudić A, Brkić S, Vasiljević Z, Kojić M, Medić D, Ćirković I, Jovčić B. Molecular Epidemiology of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae in Serbia from 2013 to 2016. Antimicrob Agents Chemother. 2017;61(5):pii:e02550-16.
  • Miljkovic M, Uzelac G, Mirkovic N, Devescovi G, Diep DB, Venturi V, Kojic M. LsbB Bacteriocin Interacts with the Third Transmembrane Domain of the YvjB Receptor. Appl Environ Microbiol. 2016;82(17):5364-5374.
  • Novović K, Mihajlović S, Dinić M, Malešević M, Miljković M, Kojić M, Jovčić B. Acinetobacter spp. porin Omp33-36: Classification and transcriptional response to carbapenems and host cells. PLOS One. 2018; 13(8):e0201608.

Vojvode Stepe 444a
Poštanski fah 23
11010 Beograd, Srbija

Tel: +381 11 3975960
Faks: +381 11 3975808 


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