Laboratory for Molecular Microbiology

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Research

Unique bacterial collection encompassing lactic acid bacteria (LAB) isolated from traditional food products, LAB of human origin and clinicaly relevant and environmental microorganisms enables the up-to-date research in Laboratory for Molecular Microbiology (LMM) in the following areas:

I Beneficial microbes and their products against multi-drug resistant pathogens

  • characterization and cloning of new antibiotic resistance genes;
  • molecular basis of virulence factors;
  • mechanisms involved in prevention of formation and/or  biofilm degradation;
  • new antimicrobial molecules (antibiotics, bacteriocins, secondary metabolites)
  • characterization and application of adhesins - molecules that prevent pathogens binding;
  • bacteriophages, as antibiotic replacament therapy.

II  Host-microbe interactions

  • LAB isolates as producers of bioactive compounds acting as immunomodulators, neurotransmitters or protectors in the host
  • LAB probiotic potential in specific diseases and pathological conditions (IBD, diabetes, pain, multiple sclerosis, intoxications);
  • enterococci: virulent vs. probiotic potential analysis;
  • microbiota composition in correlation with autoimmune and neurodevelopmental diseases.

Innovative activities of LMM are focused on formulations of innovative probiotic and starter cultures for the production of functional food for humans and animals, as well as the formulations of new antimicrobial compounds as substitutes for antibiotics and food preservatives.

Current projects
Selected publications
  • Kulas J, Mirkov I, Tucovic D, Zolotarevski L, Glamoclija J, Veljovic K, Tolinacki M, Golic N, Kataranovski M. Pulmonary Aspergillus fumigatus infection in rats affects gastrointestinal homeostasis. Immunobiology. 2019;224(1):116-123.
  • Sokovic Bajic S, Djokic J, Dinic M, Veljovic K, Golic N, Mihajlovic S, Tolinacki M. GABA-producing natural dairy isolate from artisanal Zlatar cheese attenuates gut inflammation and strengthens gut epithelial barrier in vitro. Front Microbiol. 2019;10:527
  • Popovic N, Djokic J, Brdaric E, Dinic M, Terzic-Vidojevic A, Golic N, Veljovic K. The influence of heat-killed Enterococcus faecium BGPAS1-3 on the tight junction protein expression and immune function in differentiated Caco-2 cells infected with Listeria monocytogenes ATCC 19111. Front Microbiol. 2019;10:412.
  • Stanisavljević S, Čepić A, Bojić S, Veljović K, Mihajlović S, Đedović N, Jevtić B, Momčilović M, Lazarević M, Mostarica Stojković M, Miljković Đ, Golić N. Oral neonatal antibiotic treatment perturbs gut microbiota and aggravates central nervous system autoimmunity in Dark Agouti rats. Sci Rep. 2019;9:918.
  • Lozo J, Mirkovic N, O'Connor PM, Malesevic M, Miljkovic M, Polovic N, Jovcic B, Cotter PD, Kojic M. Lactolisterin BU, a Novel Class II Broad-Spectrum Bacteriocin from Lactococcus lactis subsp. lactis bv. diacetylactis BGBU1-4. Appl Environ Microbiol. 2017;83(21):pii:e01519-17.
  • Lukic J, Chen V, Strahinic I, Begovic J, Lev-Tov H, Davis SC, Tomic-Canic M, Pastar I. Probiotics or pro-healers: the role of beneficial bacteria in tissue repair. Wound Repair Regen. 2017;25(6):912-922.
  • Filipic B, Malesevic M, Vasiljevic Z, Lukic J, Novovic K, Kojic M, Jovcic B. Uncovering Differences in Virulence Markers Associated with Achromobacter Species of CF and Non-CF Origin. Front Cell Infect Microbiol. 2017;7:224.
  • Novović K, Trudić A, Brkić S, Vasiljević Z, Kojić M, Medić D, Ćirković I, Jovčić B. Molecular Epidemiology of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae in Serbia from 2013 to 2016. Antimicrob Agents Chemother. 2017;61(5):pii:e02550-16.
  • Miljkovic M, Uzelac G, Mirkovic N, Devescovi G, Diep DB, Venturi V, Kojic M. LsbB Bacteriocin Interacts with the Third Transmembrane Domain of the YvjB Receptor. Appl Environ Microbiol. 2016;82(17):5364-5374.
  • Novović K, Mihajlović S, Dinić M, Malešević M, Miljković M, Kojić M, Jovčić B. Acinetobacter spp. porin Omp33-36: Classification and transcriptional response to carbapenems and host cells. PLOS One. 2018; 13(8):e0201608.
Contact

Vojvode Stepe 444a
Poštanski fah 23
11010 Beograd, Srbija

Tel: +381 11 3975960
Faks: +381 11 3975808

lab6@imgge.bg.ac.rs 

RESEARCHERS

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