Laboratory for Molecular Biology

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Research

In the Laboratory for Molecular Biology we study molecular mechanisms that underlie cardiovascular, malignant, pulmonary and neuromuscular diseases. We primarily aim to elucidate basic physiological processes and etiopathological mechanisms in these diseases, with focus on translational potential of our research. Our main interests include:

  • Molecular mechanisms of various biological processes including haemostasis, inflammation, tissue remodeling and response to mechanical and oxidative stress.
  • Biological functions of selected molecules and their role in diseases of interest: MARP proteins, prothrombin, alpha 1-antitrypsin, TGFB1, SMAD4, CYP2C19 and VKORC1.
  • Influence of gene variants and environmental factors on the phenotype.
  • Identification and functional characterization of molecular markers.
  • Pharmacogenetics.
  • In vitro (primary and continuous cell lines) and in vivo (zebra fish) study of selected physiological and pathological interests.
  • Development of methods for non-invasive molecular diagnostics.

Laboratory for Molecular Biology successfully collaborates with a number of scientific research and health institutions in Serbia, as well as eminent foreign institutes. We are open to all types of cooperation.

Curent project
Selected publications
  • Boskovic S, Marín-Juez R, Jasnic J, Reischauer S, El Sammak H, Kojic A, Faulkner G, Radojkovic D, Stainier DYR, Kojic S. Characterization of zebrafish (Danio rerio) muscle ankyrin repeat proteins reveals their conserved response to endurance exercise. PlosOne. 2018. DOI: 10.1371/journal.pone.0204312
  • Dragicevic S, Kosnik M, Divac Rankov A, Rijavec M, Milosevic K, Korosec P, Skerbinjek Kavalar M, Nikolic A. The Variants in the 3' Untranslated Region of the Matrix Metalloproteinase 9 Gene as Modulators of Treatment Outcome in Children with Asthma. Lung. 2018;196(3):297-303.
  • Novkovic M, Matic D, Kusic-Tisma J, Antonijevic N, Radojkovic D, Rakicevic L. Analysis of CYP2C19 genotype associated with bleeding in Serbian STEMI-patients undergone primary PCI and treated with clopidogrel. Eur J Clin Pharmacol. 2018;74(4):443-451.
  • Rakicevic L, Nestorovic A. Pharmacogenetics of Clopidogrel Therapy and Neurointerventional Procedures: We Need Precision Data for Precision Medicine. Clin Pharmacol Ther. 2018 Jun 19. doi: 10.1002/cpt.1105.
  • Divac Rankov A, Ljujić M, Petrić M, Radojković D, Pešić M, Dinić J. Targeting autophagy to modulate cell survival: a comparative analysis in cancer, normal and embryonic cells. Histochem Cell Biol. 2017;148(5):529-544.
  • Djordjevic V, Kovac M, Miljic P, Murata M, Takagi A, Pruner I, Francuski D, Kojima T, Radojkovic D. A novel prothrombin mutation in two families with prominent thrombophilia--the first cases of antithrombin resistance in a Caucasian population. J Thromb Haemost. 2013;11(10):1936-1939.
  • Miljic P, Gvozdenov M, Takagi Y, Takagi A, Pruner I, Dragojevic M, Tomic B, Bodrozic J, Kojima T, Radojkovic D, Djordjevic V. Clinical and biochemical characterization of the Prothrombin Belgrade mutation in a large Serbian pedigree: new insights into antithrombin resistance mechanism. J Thromb Haemost. 2017;15(4):670-677.
  • Supic G, Zeljic K, Rankov AD, Kozomara R, Nikolic A, Radojkovic D, Magic Z. miR-183 and miR-21 expression as biomarkers of progression and survival in tongue carcinoma patients. Clin Oral Investig 2017 Jun 14. doi: 10.1007/s00784-017-2126-y.
  • Jasnic-Savovic J, Krause S, Savic S, Kojic A, Kovcic V, Boskovic S, Nestorovic A, Rakicevic L, Schreiber-Katz O, Vogel JG, Schoser BG, Walter MC, Valle G, Radojkovic D, Faulkner G, Kojic S. Differential expression and localization of Ankrd2 isoforms in human skeletal and cardiac muscles. Histochem Cell Biol. 2016;146(5):569-584.
  • Nikolic A, Ristanovic M, Zivaljevic V, Rankov AD, Radojkovic D, Paunovic I. SMAD4 gene promoter mutations in patients with thyroid tumors. Exp Mol Pathol. 2015;99(1):100-103.
Contact

Vojvode Stepe 444a
P.O BOX 23
11010 Beograd, Srbija

Tel: +381 11 3976658
Faks: +381 11 3975808

labmolbio@imgge.bg.ac.rs 

    RESEARCHERS

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