Laboratory for Human Molecular Genetics

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Research

Laboratory for Human Molecular Genetics (LHMG) has a long standing expertise in studying the expression and function of human SOX genes and the roles of signaling pathways and epigenetic mechanisms in the regulation of their activities. In addition, we investigate the effects of the modulations of SOX genes expression on neural differentiation and malignant potential of cells. Also, we analyze the role of SOX genes in maintenance of pluripotency and tumorigenic potential of cancer stem cells, as well as in their response on chemoradiotherapy.

Due to increasing interest for alternative therapeutic approaches in the treatment of various pathological conditions (tumors, neurodegenerative diseases), one of our research goals is to evaluate potential antitumour, anti-inflammatory and neuroprotective properties of bioactive and synthetic compounds using in vitro tests for cytotoxicity, viability, intracellular stress, proliferation, apoptosis, adhesion and migration.

LHMG is studying the mitochondrial DNA (mtDNA) variability in population of Serbia from population genetics, phylogenetic and phylogeographic aspects in order to get a better insight into the contribution of demographic and other processes in modeling the contemporary mitochondrial gene pool of the Serbian population.

One of our research interests is focused on studying the pathophysiological mechanisms that lead to neurodevelopmental disorders in patients with 22q11.2 microdeletion.

LHMG provides:

  • Prenatal and postnatal detection of structural chromosomal abnormalities (microdeletions) using fluorescent in situ hybridization (FISH)
  • Analysis of sperm DNA fragmentation which complements the existing protocols for sterility therapy
  • Detection of polymorphisms in the gene for the follicle-stimulating hormone receptor (FSHR) which are associated with the ovarian response to FSH in women undergoing assisted reproductive technology
  • Determination of polymorphisms in genes which are important for selection of economic trait loci in domestic animals.

LHMG is modern well-equipped laboratory with highly competent researchers in the field of human molecular genetics. Аssociates actively participate in theoretical education and practical training of students at the Faculty of Biology, University of Belgrade.

 

Current projects
Selected publications
  • Popovic J., Klajn A., Paunesku T., Ma Q., Chen S., Lai B., Stevanovic M., Woloschak G. Neuroprotective Role of Selected Antioxidant Agents in Preventing Cisplatin-Induced Damage of Human Neurons In Vitro. Cell Mol Neurobiol. 2019, 39(5):619-636.
  • Zaletel I, Schwirtlich M, Perović M, Jovanović M, Stevanović M, Kanazir S, Puškaš N. Early Impairments of Hippocampal Neurogenesis in 5xFAD Mouse Model of Alzheimer's Disease Are Associated with Altered Expression of SOXB Transcription Factors. J Alzheimers Dis. 2018, 65(3):963-976
  • Videnović M, Mojsin M, Stevanović M, Opsenica I, Srdić-Rajić T, Šolaja B. Benzothiazole carbamates and amides as antiproliferative species. Eur J Med Chem. 2018, 157:1096-1114.
  • Marjanovic Vicentic J, Drakulic D, Garcia I, Vukovic V, Aldaz P, Puskas N, Nikolic I, Tasic G, Raicevic S, Garros-Regulez L, Sampron N, Atkinson MJ, Anastasov N, Matheu A, Stevanovic M. SOX3 can promote the malignant behavior of glioblastoma cells. Cell Oncol (Dordr). 2018, 42(1):41-54
  • Davidovic S, Malyarchuk B, Aleksic J, Derenko M, Topalovic V, Litvinov A, Skonieczna K, Rogalla U, Grzybowski T, Stevanovic M, Kovacevic-Grujicic N. Mitochondrial super-haplogroup U diversity in Serbians. Ann Hum Biol. 2017, 19:1-11.
  • Topalovic V, Krstic A, Schwirtlich M, Dolfini D, Mantovani R, Stevanovic M, Mojsin M. Epigenetic regulation of human SOX3 gene expression during early phases of neural differentiation of NT2/D1 cells. PLoS One. 2017, 12(9):e0184099
  • Stojkovic D, Kovacevic-Grujicic N, Reis FS, Davidovic S, Barros L, Popovic J, Petrovic I, Pavic A, Glamoclija J, Ciric A, Stevanovic M, Ferreira I.C.F.R., Sokovic M. Chemical composition of the mushroom Meripilus giganteus Karst. And bioactive properties of its methanolic extract. LWT - Food Science and Technology. 2017, 79:454-462
  • Stanisavljevic D, Petrovic I, Vukovic V, Schwirtlich M, Gredic M, Stevanovic M, Popovic J. SOX14 activates the p53 signaling pathway and induces apoptosis in a cervical carcinoma cell line. PLoS One. 2017, 12(9):e0184686.
  • Cuturilo G, Drakulic D, Jovanovic I, Krstic A, Djukic M, Skoric D, Mijovic M, Stefanovic I, Milivojevic M, Stevanovic M. Improving the Diagnosis of Children with 22q11.2 Deletion Syndrome: A Single-center Experience from Serbia. Indian Pediatr. 2016, 53(9):786-789.
  • Petrovic I, Milivojevic M, Popovic J, Schwirtlich M, Rankovic B, Stevanovic M. SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines. PLoS One. 2015, 10(11):e0143591.
Contact

Vojvode Stepe 444a
P.O BOX 23
11010 Belgarde, Serbia

Tel: +381 11 3976212, +381 65 3976212
Faks: +381 11 3975808

hmgbox@imgge.bg.ac.rs 

RESEARCHERS

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