Probiotics and Microbiota-Host Interaction

Group for Probiotics and Microbiota-Host Interaction (GPMHI) has been recognized for the pioneering work in Serbia in the field of probiotics, host-microbe interactions and gut microbiota. The GPMHI team encompassing molecular microbiologists, molecular geneticists, immunologists, pharmacists and bioinformatics. Our research is devoted to studying the interactions between beneficial bacteria and their human or animal hosts and to deciphering the molecular mechanisms staying behind the cross-talk between microbes and their hosts.

Research of the GPMHI focuses the following research topics:

• Relationship between microbiota composition and immunotherapy efficacy
• Microbiota in neurodevelopmental and autoimmune diseases
• Involvement of microbiota in aging process (in model system Caenorhabditis elegans)
• Molecular characterization of probiotic potential of dairy isolates of lactic acid bacteria (LAB)
• Molecular mechanisms of action of non-cytotoxic bioactive compounds produced by LAB
• The role of exopolysaccharides (EPS) as postbiotic in prevention and alleviation of cadmium induced toxicity
• Development of probiotic and postbiotic therapies
• Probiotic administration in reduction of inflammation and oxidative stress in lungs
• The role of microbiota and probiotic treatment in stimulation of farmed fish growth
• The role of the microbiota of flour and sourdough on the bio- and techno-functionality of bread and the effects of bread on intestinal cell models

Innovation activities of LPMHI are focused on formulations of innovative probiotics and starter cultures for production of functional food for humans and animals.

IMGGE work program for 2023
NextGenBiotics - The use of integrative multi-omics approach in cultivation and characterization of gut bacteria related to microbiota-gut-brain axis as a source for Next Generation Probiotics

HEAD OF THE GROUP

• Nataša Golić - Full research professor

FULL RESEARCH PROFESSOR

• Ivana Strahinjić
• Amarela Terzić-Vidojević
• Katarina Veljović
• Maja Tolinački

ASSOCIATE RESEARCH PROFESSOR

• Jovanka Lukić
• Jelena Đokić
• Milica Živković

ASSISTANT RESEARCH PROFESSOR

• Miroslav Dinić
• Svetlana Sokivić Bajić
• Nikola Popović

RESEARCH ASSISTANT

• Еmilija Brdarić
• Dušan Radojević

JUNIOR RESEARCHER

• Aleksandra Bisenić
• Dušan Stevanović
• Stefan Jakovljević
• Hristina Mitrović

OTHERS

• Dušanka Popović, research assistant

• Myeloid-derived suppressor cells prevent disruption of the gut barrier, preserve microbiota composition, and potentiate immunoregulatory pathways in a rat model of experimental autoimmune encephalomyelitis
  Radojević D, Bekić M, Gruden-Movsesijan A, Ilić N, Dinić M, Bisenić A, Golić N, Vučević D, Đokić J, Tomić S
  Gut Microbes. 2022;14(1):2127455.
• Serum-derived extracellular vesicles: Novel biomarkers reflecting the disease severity of COVID-19 patients
  Tertel T, Tomić S, Đokić J, Radojević D, Stevanović D, Ilić N, Giebel B, Kosanović M
  J Extracell Vesicles. 2022;11(8):e12257. 
• Lactobacillus brevis BGZLS10-17 and Lb. plantarum BGPKM22 Exhibit Anti-Inflammatory Effect by Attenuation of NF-κB and MAPK Signaling in Human Bronchial Epithelial Cells
  Stankovic M, Veljovic K, Popovic N, Kojic S, Dunjic Manevski S, Radojkovic D, Golic N
  Int J Mol Sci. 2022;23(10):5547.
• Host-commensal interaction promotes health and lifespan in Caenorhabditis elegans through the activation of HLH-30/TFEB-mediated autophagy
  Dinić M, Herholz M, Kačarević U, Radojević D, Novović K, Đokić J, Trifunović A, Golić N
  Aging (Albany NY). 2021;13(6):8040-8054. 
• Protective Effect of an Exopolysaccharide Produced by Lactiplantibacillus plantarum BGAN8 Against Cadmium-Induced Toxicity in Caco-2 Cells
  Brdarić E, Soković Bajić S, Đokić J, Đurđić S, Ruas-Madiedo P, Stevanović M, Tolinački M, Dinić M, Mutić J, Golić N, Živković M
  Front Microbiol. 2021;12:759378. 
• Enterococci from Raw-Milk Cheeses: Current Knowledge on Safety, Technological, and Probiotic Concerns
  Terzić-Vidojević A, Veljović K, Popović N, Tolinački M, Golić N
  Foods. 2021;10(11):2753. 
• Techno-Functional Performance of Emmer, Spelt and Khorasan in Spontaneously Fermented Sourdough Bread
  Škrobot D, Dapčević-Hadnađev T, Tomić J, Maravić N, Popović N, Jovanov P, Hadnađev M
  Foods. 2022;11(23):3927. 
• Ancient Wheat Varieties and Sourdough Fermentation as a Tool to Increase Bioaccessibility of Phenolics and Antioxidant Capacity of Bread
  Dapčević-Hadnađev T, Stupar A, Stevanović D, Škrobot D, Maravić N, Tomić J, Hadnađev M.
  Foods. 2022;11(24):3985.
• Pike-perch larvae growth in response to administration of lactobacilli-enriched inert feed during first feeding
  Ljubobratović U, Fazekas G, Koljukaj A, Ristovic T, Vass V, Ardo L, Stanisavljević N, Vukotić G, Pešić M, Milinčić D, Kostić A, Lukić J
  Aquaculture. 2021;542:736901. 
• Probiotics or pro-healers: the role of beneficial bacteria in tissue repair
  Lukic J, Chen V, Strahinic I, Begovic J, Lev-Tov H, Davis SC, Tomic-Canic M, Pastar I
  Wound Repair Regen. 2017;25(6):912-922.

Head Office / Mailing address:
Vojvode Stepe 444a,
11042 Belgrade 152, Serbia

Tel: +381 11 3975960
Faks: +381 11 3975808

host-microbe@imgge.bg.ac.rs