Molecular Microbiology

GMM works on new determinants/mechanisms of bacterial resistance to antibiotics, their spread among pathogenic bacteria and on the discovery of new antimicrobial agents (antimicrobial peptides, lipopeptides, antibiotics and bacteriophages), anti-virulence factors and mechanisms used by beneficial bacteria in competition with pathogens for the same receptors on the host.

GMM is mainly engaged in fundamental research using a large number of classical and modern methods of microbiology, molecular genetics of microorganisms and genetic engineering in order to: isolate new bacterial strains with antimicrobial activity, clone genes of interest (both responsible for antibiotic resistance and synthesis of antimicrobial compounds), study regulation of their expression, overexpression, analyze the mechanisms of their action and application.

IMGGE work program for 2023
Smart Pet Toothbrush
BreviProtect – Zootechnical feed additive for honey bees

HEAD OF THE GROUP

• Milan Kojic - Full research professor

FULL RESEARCH PROFESSOR

• Jelena Begović
• Goran Jovanović

ASSOCIATE RESEARCH PROFESSOR

• Nemanja Stanisavljević

ASSISTANT RESEARCH PROFESSOR

• Katarina Novović
• Milka Malešević
• Danka Matijašević

RESEARCH ASSISTANT

• Mina Obradović
• Lazar Gardijan

JUNIOR RESEARCHER

• Jovana Ćurčić

OTHERS

• Goran Vukotić, assistant research professor
• Branko Jovčić, full professor
• Nemanja Mirković, assistant research professor

• The large plasmidome of Lactococcus lactis subsp. lactis bv. diacetylactis S50 confers its biotechnological properties
  Malesevic M, Stanisavljevic N, Miljkovic M, Jovcic B, Filipic B, Studholme DJ, Kojic M
  Int J Food Microbiol. 2021;337:108935
• Natural bacterial isolates as an inexhaustible source of new bacteriocins
  Lozo J, Topisirovic L, Kojic M
  Appl Microbiol Biotechnol. 2021;105(2):477-492
• Characterization, Antibiofilm, and Depolymerizing Activity of Two Phages Active on Carbapenem-Resistant Acinetobacter baumannii
  Vukotic G, Obradovic M, Novovic K, Di Luca M, Jovcic B, Fira D, Neve H, Kojic M, McAuliffe O
  Front Med (Lausanne). 2020;7:426
• Pseudomonas aeruginosa quorum sensing inhibition by clinical isolate Delftia tsuruhatensis 11304: involvement of N-octadecanoylhomoserine lactones
  Malešević M, Di Lorenzo F, Filipić B, Stanisavljević N, Novović K, Senerovic L, Polović N, Molinaro A, Kojić M, Jovčić B
  Sci Rep. 2019;9(1):16465
• Brevibacillus laterosporus strains BGSP7, BGSP9 and BGSP11 isolated from silage produce broad spectrum multi-antimicrobials
  Miljkovic M, Jovanovic S, O'Connor PM, Mirkovic N, Jovcic B, Filipic B, Dinic M, Studholme DJ, Fira D, Cotter PD, Kojic M
  PLoS One. 2019;14(5):e0216773
• Acinetobacter spp. porin Omp33-36: Classification and transcriptional response to carbapenems and host cells
  Novović K, Mihajlović S, Dinić M, Malešević M, Miljković M, Kojić M, Jovčić B
  PLoS 2018;13(8):e0201608
• Uncovering Differences in Virulence Markers Associated with Achromobacter Species of CF and Non-CF Origin
  Filipic B, Malesevic M, Vasiljevic Z, Lukic J, Novovic K, Kojic M, Jovcic B
  Front Cell Infect Microbiol. 2017;7:224
• Lactolisterin BU, a Novel Class II Broad-Spectrum Bacteriocin from Lactococcus lactis subsp. lactis bv. diacetylactis BGBU1-4
  Lozo J, Mirkovic N, O'Connor PM, Malesevic M, Miljkovic M, Polovic N, Jovcic B, Cotter PD, Kojic M
  Appl Environ Microbiol. 2017;83(21): e01519-17
• Molecular Epidemiology of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae in Serbia from 2013 to 2016
  Novović K, Trudić A, Brkić S, Vasiljević Z, Kojić M, Medić D, Ćirković I, Jovčić B
  Antimicrob Agents Chemother. 20174;61(5):e02550-16
• LsbB Bacteriocin Interacts with the Third Transmembrane Domain of the YvjB Receptor
  Miljkovic M, Uzelac G, Mirkovic N, Devescovi G, Diep DB, Venturi V, Kojic M
  Appl Environ Microbiol. 2016;82(17):5364-5374
• Novel RclSAR three-component system regulates expression of the intI1 gene in the stationary growth phase
  Novović K, Malešević M, Gardijan L, Kojić M, Jovčić B 
  Res Microbiol. 2022;173(1-2):103885 
• Burkholderia cepacia YtnP and Y2-aiiA lactonases inhibit virulence of Pseudomonas aeruginosa via quorum quenching activity
  Malešević M, Stanisavljević N, Novović K, Polović N, Vasiljević Z, Kojić M, Jovčić B
  Microb Pathog. 2020;149:104561

Head Office / Mailing address:
Vojvode Stepe 444a,
11042 Belgrade 152, Serbia

Tel: +381 11 3975960
Mob:+381 65 3975960
Faks: +381 11 3975808

lab6@imgge.bg.ac.rs