Viši naučni saradnik
Laboratorija za molekularnu biologiju (LMB)

Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI),
Univerzitet u Beogradu,

V. Stepe 444a, 11010 Beograd, Srbija
Mob:  +381 64 3976658
Tel:   +381 11 3976658
Fax:   +381 11 397 58 08
E-mail: valentina@imgge.bg.ac.rs                                   

OBRAZOVANJE

2010 - Doktor bioloških nauka, Biološki fakultet (BF), Univerzitet u Beogradu (UB),
("Analiza uticaja 3' kraja  humanog protrombinskog gena na njegovu ekspresiju i patogenezu trombofilije")
2002 - Magistar molekularne biologije i fiziologije, BF, UB
2000 - Diplomirani molekularni biolog i fiziolog, BF, UB

ISTRAŽIVAČKO ISKUSTVO

2015 - viši naučni saradnik, IMGGI, UB
2010-2015
- naučni saradnik, IMGGI, UB
2002-2010 - istraživač saradnik, IMGGI, UB
2000-2002 - stipendista Ministrava za nauku i tehnološki razvoj republike Srbije, LMB, IMGGI, UB

RADNO ISKUSTVO

2011 - rukovodilac podprojekta P1 u okviru projekta Kompleksne bolesti kao model sistem za proučavanje modulacije fenotipa-strukturna i funkcionalna analiza molekularnih biomarkera; MPNTR Republike Srbije (173008)
2011- predavač na doktorskim studijama na Biološkom fakultetu, UB, u okviru studijskog programa Molekularna biologija

OSTALE AKTIVNOSTI

2014 - Predsednik Etičkog odbora IMGGI, UB
2013 - član International Society on Thrombosis and Haemostasis           

OBLAST NAUČNOG INTERESOVANJA

3' kraj gena za protrombin i regulacija ekspresije gena za protrombin,funkcionalna analiza  genskih varijanti u 3' kraju gena za protrombin, 3' kraj gena za protrombin u etiologiji trombofilije, kancera i inflamacije,Protrombin Beograd mutacija (FII c.1787G>A),definisanje novih trombofilnih markera,nasledna trombofilija

ODABRANI NAUČNI RADOVI

Poor pregnancy outcome in women with homozygous type-II HBS antithrombin deficiency. Kovac M, Mitic G, Miljic P, Mikovic Z, Mandic V, Djordjevic V, Radojkovic D, Bereczky Z, Muszbek L. Thromb Res. 2014 Jun;133(6):1158-60.  [http://www.ncbi.nlm.nih.gov/pubmed/24702813]

Determination of transgene copy number in stably transfected mammalian cells by PCR-capillary electrophoresis assay. Pruner I, Djordjevic V, Gvozdenov M, Tomic B, Radojkovic D. Biochem Genet. 2014 Apr;52(3-4):159-65. [http://www.ncbi.nlm.nih.gov/pubmed/24292648]

A novel prothrombin mutation in two families with prominent thrombophilia--the first cases of antithrombin resistance in a Caucasian population. Djordjevic V, Kovac M, Miljic P, Murata M, Takagi A, Pruner I, Francuski D, Kojima T, Radojkovic D. J Thromb Haemost. 2013 Oct;11(10):1936-9. [http://www.ncbi.nlm.nih.gov/pubmed/23927452]

Prothrombotic genetic risk factors in stroke: a possible different role in pediatric and adult patients. Djordjevic V, Stankovic M, Brankovic-Sreckovic V, Rakicevic L, Damnjanovic T, Antonijevic N, Radojkovic D. Clin Appl Thromb Hemost. 2012 Nov;18(6):658-61. [http://www.ncbi.nlm.nih.gov/pubmed/22275392]

Are thrombophilia more multifactorial than we thought: report of mosaicism for FII G20210A and novel FII T20061C gene variants. Djordjevic V, Mitic G, Pruner I, Kovac M, Radojkovic D. J Thromb Haemost. 2012 Feb;10(2):301-3. [http://www.ncbi.nlm.nih.gov/pubmed/22141575]

+1040 C/T polymorphism in coding region of thrombin-activatable fibrinolysis inhibitor gene and the risk of idiopathic recurrent fetal loss. Pruner I, Djordjevic V, Miljic P, Kovac M, Antonijevic N, Rakicevic L, Radojkovic D. Blood Coagul Fibrinolysis. 2010 Oct;21(7):679-82.    [http://www.ncbi.nlm.nih.gov/pubmed/20729722]

Thrombophilia in women with pregnancy-associated complications: fetal loss and pregnancy-related venous thromboembolism. Kovac M, Mitic G, Mikovic Z, Djordjevic V, Savic O, Mandic V, Rakicevic LJ, Antonijevic N, Radojkovic D. Gynecol Obstet Invest. 2010;69(4):233-8. [http://www.ncbi.nlm.nih.gov/pubmed/20068329]

The use of D-dimer with new cutoff can be useful in diagnosis of venous thromboembolism in pregnancy. Kovac M, Mikovic Z, Rakicevic L, Srzentic S, Mandic V, Djordjevic V, Radojkovic D, Elezovic I. Eur J Obstet Gynecol Reprod Biol. 2010 Jan;148(1):27-30 [http://www.ncbi.nlm.nih.gov/pubmed/19804940]

Genetic risk factors for arterial ischemic stroke in children: a possible MTHFR and eNOS gene-gene interplay? Djordjevic V, Stankovic M, Brankovic-Sreckovic V, Rakicevic L, Radojkovic D. J Child Neurol. 2009 Jul;24(7):823-7. [http://www.ncbi.nlm.nih.gov/pubmed/19372095]

Procarboxypeptidase U (TAFI) contributes to the risk of thrombosis in patients with hereditary thrombophilia. Heylen E, Miljic P, Willemse J, Djordjevic V, Radojkovic D, Colovic M, Elezovic I, Hendriks D. Thromb Res. 2009 Sep;124(4):427-32. [http://www.ncbi.nlm.nih.gov/pubmed/19195685]

Arterial ischemic stroke in a child with beta-thalassemia trait and methylentetrahydrofolate reductase mutation. Brankovic-Sreckovic V, Milic Rasic V, Djordjevic V, Kuzmanovic M, Pavlovic S. J Child Neurol. 2007 Feb;22(2):208-10. [http://www.ncbi.nlm.nih.gov/pubmed/17621484]

Prevalence of factor V leiden, factor V cambridge, factor II G20210A and  methylenetetrahydrofolate reductase C677T mutations in healthy and thrombophilic Serbian populations. Djordjevic V, Rakicevic LJ, Mikovic D, Kovac M, Miljic P, Radojkovic D, Savic A. Acta Haematol. 2004;112(4):227-9. [http://www.ncbi.nlm.nih.gov/pubmed/15564739]

Severe central nervous system thrombotic events in hemoglobin Sabine patient. Pavlovic S, Kuzmanovic M, Urosevic J, Poznanic J, Zoranovic T, Djordjevic V, Rasovic N, Bunjevacki G, Cvorkov-Drazic M, Colovic M. Eur J Haematol. 2004 Jan;72(1):67-70. [http://www.ncbi.nlm.nih.gov/pubmed/14962267]

Combined severe factor XII deficiency and homozygous factor V Leiden mutation in a patient with venous thrombosis. Miljic P, Colovic M, Boskovic D, Rakicevic Lj, Djordjevic V. Thromb Res. 2002 May 15;106(4-5):265-7. [http://www.ncbi.nlm.nih.gov/pubmed/12297136]

Effect of steroid hormone deprivation on the expression of ecto-ATPase in distinct brain regions of female rats. Nedeljkovic N, Djordjevic V, Horvat A, Nikezic G, Kanazir DT. Physiol Res. 2000;49(4):419-26. [http://www.ncbi.nlm.nih.gov/pubmed/11072801]