Naučni savetnik
Laboratorija za molekularnu biomedicinu

Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI),
Univerzitet u Beogradu,

V. Stepe 444a, 11010 Beograd, Srbija
Mob: +381 65 3976445
Tel:  +381 11 3976445
Fax: +381 11 397 58 08
E-mail: sonya@sezampro.rs                                   

OBRAZOVANJE

2001 - Doktor bioloških nauka, Biološki fakultet (BF), Univerzitet u Beogradu (UB),
(Molekularna genetika talasemijskih sindroma: korelacija između molekularne patologije i fenotipa)
1996 - Magistar bioloških nauka, BF, UB
1992 - Diplomirani molekularni biolog i fiziolog, BF, UB

ISTRAŽIVAČKO ISKUSTVO

2011 - Naučni savetnik, Institut za molekularnu genetiku i genetičko inženjerstvo, (IMGGI), UB
2007 - 2011 - Viši naučni saradnik, IMGGI, UB
2002 – 2007 - Naučni saradnik, IMGGI, UB
1996 - 2002 - Istraživač saradnik, IMGGI, UB
1993 - 1996 - Istraživač pripravnik, IMGGI, UB

RADNO ISKUSTVO

2015 - Rukovodilac Laboratorije za molekularnu biomedicinu
2013
- Rukovodilac projekata Laboratorije za molekularnu biomedicinu (LMB) IMGGI
2013 - 2001 - Rukovodilac Laboratorije za molekularnu hematologiju (LMH), IMGGI
2000 - Predavač na Doktorskim studijama na Biološkom fakultetu, UB, u okviru studijskog programa Molekularna biologija
2005 - Gostujući istraživač. Centro Ricerca M. Tettamanti, Universita di Milano-Biccoca, H. San Gerardo, Monza, Italy
1999 - Gostujući istraživač. Istituto di Clinica e Biologià dell’Età Evolutiva Università degli Studi, Cagliari, Italy
1993 - 2001 - Istraživač, LMH, IMGGI
1983 - 1994 - Profesor klavira u Muzičkoj školi

OSTALE AKTIVNOSTI           

2009 - Rukovodilac programa za popularizaciju i promociju nauke “Mala škola DNKlogije”
2011 - Nacionalni coordinator za PGENI (Pharmacogenetics for Every Nation Initiative)
2011 - Član Veća instituta UB
2012 - Član Veća grupacije medicinskih nauka UB

OBLAST NAUČNOG INTERESOVANJA

Molekularna genetika retkih bolesti, talasemija(regulacija transkripcije beta-globinskih gena, geni modifikatori), hematološki maligniteti (molekularni markeri dečje i adultne akutne i hronične mijeloidne i limfoidne leukemije, limfoma i multiplih mijeloma), molekularna osnova metaboličkih bolesti (fenilketonurija), molekularna genetika inflamatornih bolesti creva (Kronova bolest, ulcerozni kolitis, celijakija), pulmološke bolesti (tuberkuloza, idiopatska fibroza, plućna hipertenzija, sarkoidoza), reumatološke bolesti (sistemska skleroza, miozitis, reumatoidni artritis), ortopedske bolesti, inflamacija, autoimunost, korelacija genotipa i fenotipa, populaciona genetika, molekularna dijagnostika, ćelijska i genska terapija, farmakogenomika.

ODABRANI NAUČNI RADOVI

Paschou P, Drineas P, Yannaki E, Razou A, Kanaki K, Tsetsos F, Padmanabhuni SS, Michalodimitrakis M, Renda MC, Pavlovic S, Anagnostopoulos A, Stamatoyannopoulos JA, Kidd KK, Stamatoyannopoulos G. Maritime route of colonization of Europe. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9211-6 http://www.ncbi.nlm.nih.gov/pubmed/24927591

Stanković B, Radlović N, Leković Z, Ristić D, Radlović V, Nikčević G, Kotur N, Vučićević K, Kostić T, Pavlović S, Zukic B.HLA genotyping in pediatric celiac disease patients.Bosn J Basic Med Sci. 2014 Aug 16;14(3):171-6.http://www.ncbi.nlm.nih.gov/pubmed/25172978

Srzentić S, Spasovski V, Spasovski D, Zivković Z, Matanović D, Bascarević Z, Supić ZT, Stojiljković M, Karan-Djurasević T, Stanković B, Pavlović S, Nikcević G, Vukasinović Z.Association of gene variants in TLR4 and IL-6 genes with Perthes disease.Srp Arh Celok Lek. 2014 Jul-Aug;142(7-8):450-6.http://www.ncbi.nlm.nih.gov/pubmed/25233690 

Karan-Djurasevic T, Palibrk V, Zukic B, Spasovski V, Glumac I, Colovic M, Colovic N, Jurisic V, Scorilas A, Pavlovic S, Tosic N. Expression of Bcl2L12 in chronic lymphocytic leukemia patients: association with clinical and molecular prognostic markers. Med Oncol 2013, 30(1):405. http://www.ncbi.nlm.nih.gov/pubmed/23292833

Radmilovic M, Zukic B, Stojiljkovic M, Bartsakoulia M, Stankovic B, Kotur N, Dokmanovic L, Georgitsi M, Patrinos G, Pavlovic S. Functional analysis of a novel KLF1 gene promoter variation associated with hereditary persistence of fetal hemoglobin. Annals of Hematology 2013, 92(1):53-8. http://www.ncbi.nlm.nih.gov/pubmed/23161389

Spasovski V, Tosic N, Nikcevic G, Stojiljkovic M, Zukic B, Radmilovic M, Karan – Djurasevic T, Srzentic S, Colovic M, Pavlovic S. The influence of novel transcriptional regulatory element in intron 14 on expression of Janus kinase 2 gene in myeloproliferative neoplasms. J Appl Genet 2013, 54(1):21-6. http://www.ncbi.nlm.nih.gov/pubmed/23188718

Rodic P, Pavlovic S, Kostic T, Suvajdzic Vukovic N, Djordjevic M, Sumarac Z, Dajak M, Bonaci Nikolic B, Janic D. Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease. Blood Cells Mol Dis. 2013 50: 222-225. http://www.ncbi.nlm.nih.gov/pubmed/23265739

Jančić I, Arsenović-Ranin N, Sefik-Bukilica M, Zivojinović S, Damjanov N, Spasovski V, Srzentić S, Stanković B, Pavlović S. -174G/C interleukin-6 gene promoter polymorphism predicts therapeutic response to etanercept in rheumatoid arthritis. Rheumatol Int. 2013 Jun;33(6):1481-6. http://www.ncbi.nlm.nih.gov/pubmed/23233117

Klampfl T, Milosevic JD, Puda A, Schönegger A, Bagienski K, Berg T, Harutyunyan AS, Gisslinger B, Rumi E, Malcovati L, Pietra D, Elena C, Della Porta MG, Pieri L, Guglielmelli P, Bock C, Doubek M, Dvorakova D, Suvajdzic N, Tomin D, Tosic N, Racil Z, Steurer M, Pavlovic S, Vannucchi AM, Cazzola M, Gisslinger H, Kralovics R. Complex Patterns of Chromosome 11 Aberrations in Myeloid Malignancies Target CBL, MLL, DDB1 and LMO2. PLoS One. 2013 Oct 16;8(10):e77819. http://www.ncbi.nlm.nih.gov/pubmed/24147083

Milosevic JD, Puda A, Malcovati L, Berg T, Hofbauer M, Stukalov A, Klampfl T, Harutyunyan AS, Gisslinger H, Gisslinger B, Burjanivova T, Rumi E, Pietra D, Elena C, Vannucchi AM, Doubek M, Dvorakova D, Robesova B, Wieser R, Koller E, Suvajdzic N, Tomin D, Tosic N, Colinge J, Racil Z, Steurer M, Pavlovic S, Cazzola M, Kralovics R. Clinical significance of genetic aberrations in secondary acute myeloid leukemia. Am J Hematol. 2012, 87(11):1010-6. http://www.ncbi.nlm.nih.gov/pubmed/22887079

Giardine B, Borg J, Higgs D, Peterson K, Philipsen S, Maglott D, Singleton B, Anstee D, Basak AN, Clark B, Costa F, Faustino P, Fedosyuk H, Felice A, Francina A, Galanello R, Gallivan M, Georgitsi M, Gibbons R, Giordano P, Harteveld C, Hoyer J, Jarvis M, Joly P, Kanavakis E, Kollia P, Menzel S, Miller W, Moradkhani K, Old J, Papachatzopoulou A, Papadakis M, Papadopoulos P, Pavlovic S, Perseu L, Radmilovic M, Riemer C, Satta S, Schrijver I, Stojiljkovic M, Thein SL, Traeger-Synodinos J, Tully R, Wada T, Waye J, Wiemann C, Zukic B, Chui D, Wajcman H, Hardison R, Patrinos P. Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach. Nat Genet 2011: 43(4): 295-301. http://www.ncbi.nlm.nih.gov/pubmed/21423179

Zukic B, Radmilovic M, Stojiljkovic M, Tosic N, Pourfarzad F, Dokmanovic L, Janic D, Colovic N, Philipsen S, Patrinos G, Pavlovic S Functional analysis of the role of the TPMTgene promoter VNTR polymorphism ingene transcription. Pharmacogenomics. 2010:11 (4), 547-557. http://www.ncbi.nlm.nih.gov/pubmed/20350137

Stojiljkovic M, Zukic B, Tosic N, Karan-Djurasevic T, Spasovski V, Nikcevic G, Pavlovic S. Novel transcriptional regulatory element in the phenylalanine hydroxylase gene intron. Mol. Genet. Metab. 2010: 101 (1), 81-83.http://www.ncbi.nlm.nih.gov/pubmed/20599406

Tosic N, Stojiljkovic M, Colovic N, Colovic M, Pavlovic S. Acute myeloid leukemia with NUP98-HOXC13 fusion and FLT3 internal tandem duplication: case report and literature review. Cancer Genet. Cytogenet. 2009: 193, 98-103.http://www.ncbi.nlm.nih.gov/pubmed/19665070

Pavlovic S. TPMT gene polymorphisms: on the doorstep of personalized medicine.Indian J Med Res. 2009 May;129(5):478-80. http://www.ncbi.nlm.nih.gov/pubmed/19675373

Colovic N, Tosic N, Aveic S, Djuric M, Milic N, Bumbasirevic V, Colovic M, Pavlovic S.) Importance of early detection and follow-up of FLT3 mutations in patients with acute myeloid leukemia. Annals of Hematology 2007: 86, 741-747. http://www.ncbi.nlm.nih.gov/pubmed/17579862

Dokmanovic L, Urosevic J, Janic D, Jovanovic N, Petrucev B, Tosic N, Pavlovic S. Analysis of thiopurine S-methyltransferase Polymorhism in the Population of Serbia and Montenegro and Mercaptopurine Therapy Tolerance in Childhood Acute Lymphoblastic Leukemia. Ther. Drug. Monit. 2006: 28, 800-806. http://www.ncbi.nlm.nih.gov/pubmed/17164697

Stojiljkovic M, Jovanovic J, Djordjevic M, Grkovic S, Cvorkov Drazic M, Petrucev B, Tosic N, Karan Djurasevic T, Stojanov L, Pavlovic S. Molecular and phenotypic characteristics of patients with phenylketonuria in Serbia and Montenegro. Clin Genet. 2006 Aug;70(2):151-5. http://www.ncbi.nlm.nih.gov/pubmed/16879198

Pavlovic S, Urosevic J, Poznanic J, Perisic Lj, Petrucev B, Tosic N, Krivokapic-Dokmanovic L, Janic D, Cvorkov-Drazic M, Bunjevacki G. (2005) Molecular basis and origin of thalassemia syndromes in Serbia. Acta Haematologica 113, 175-180.http://www.ncbi.nlm.nih.gov/pubmed/15870487

Pavlovic S, Mitrovic T, Nikcevic G, Grujicic N, Lazic D, Glisin V, Popovic Z. (1999) The rat βbminy-globin promoter: nuclear protein factors and erythroid-specific induction of transcription. Cell. Mol. Life Sci. 56, 871-881.http://www.ncbi.nlm.nih.gov/pubmed/11212345