Viši naučni saradnik
Laboratorija za molekularnu biomedicinu

Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI),
Univerzitet u Beogradu,

V. Stepe 444a, 11010 Beograd, Srbija
Mob:  +381 65 39 76 445
Tel:    +381 11 39 76 445
Fax:   +381 11 397 58 08
E-mail: natasa.tosic@imgge.bg.ac.rs

OBRAZOVANJE

2010 - Doktor bioloških nauka, Biološki fakultet (BF), Univerzitet u Beogradu (UB),
(Interakcija genetičkih markera proliferacije, diferncijacije i apoptoze kod akutnih leukemija)
2002 - Magistar bioloških nauka, BF, UB
1998 - Diplomirani molekularni biolog i fiziolog, BF, UB

ISTRAŽIVAČKO ISKUSTVO

2016 - viši naučni saradnik, IMGGI, UB
2011 - 2016 - naučni saradnik, IMGGI, UB
2003 - 2011 - istraživač saradnik, IMGGI, UB
1999 - 2000 - istraživač pripravnik, Institut Vinča, Beograd

RADNO ISKUSTVO

2004 - istraživač u Laboratoriji za molekularnu biomedicinu, IMGGI, UB
2000 - 2003 - volonter u Laboratoriji za imunologiju, Zavod za transfuziju Srbije, Beograd
1999 – 2000 - istraživač u Laboratoriji za antioksidativne enzime, Institut Vinča, Beograd    

OSTALE AKTIVNOSTI

2013 -  rukovodilac podprojekta (WP2c) “Strengthening the Research Potential of IMGGE through Reinforcement of Biomedical Science of Rare Diseases in
Serbia – en route for innovation” (FP7 REGPOT-CT-2013-316088-SERBORDISinn, www.serbordisinn.rs         

OBLAST NAUČNOG INTERESOVANJA

Hematološki maligniteti, prvenstveno akutne i hronične leukemije. Genetička osnova ovih oboljenja i poremećaj procesa diferencijacije, proliferacije i apoptoze. Molekularni markeri bolesti značajni za dijagnostiku, prećenje iterapiju hematoloških maligniteta.

ODABRANI NAUČNI RADOVI

A gene expression profile associated with relapse of cytogenetically normal acute myeloid leukemia is enriched for leukemia stem cell genes. Hackl H, Steinleitner K, Lind K, Hofer S, Tosic N, Pavlovic S, Suvajdzic N, Sill H, Wieser R. Leuk Lymphoma. 2014 Aug 18:1-3.

Complex patterns of chromosome 11 aberrations in myeloid malignancies target CBL, MLL, DDB1 and LMO2. Klampfl T, Milosevic JD, Puda A, Schönegger A, Bagienski K, Berg T, Harutyunyan AS, Gisslinger B, Rumi E, Malcovati L, Pietra D, Elena C, Della Porta MG, Pieri L, Guglielmelli P, Bock C, Doubek M, Dvorakova D, Suvajdzic N, Tomin D, Tosic N, Racil Z, Steurer M, Pavlovic S, Vannucchi AM, Cazzola M, Gisslinger H, Kralovics R. PLoS One. 2013 Oct 16;8(10):e77819.

Expression of Bcl2L12 in chronic lymphocytic leukemia patients: association with clinical and molecular prognostic markers.Karan-Djurasevic T, Palibrk V, Zukic B, Spasovski V, Glumac I, Colovic M, Colovic N, Jurisic V, Scorilas A, Pavlovic S, Tosic N. Med Oncol. 2013 Mar;30(1):405

The influence of novel transcriptional regulatory element in intron 14 on the expression of Janus kinase 2 gene in myeloproliferative neoplasms. Spasovski V, Tosic N, Nikcevic G, Stojiljkovic M, Zukic B, Radmilovic M, Karan-Djurasevic T, Srzentic S, Colovic M, Pavlovic S. J Appl Genet. 2013 Feb;54(1):21-6.

Prognostic impact of NPM1 mutations in Serbian adult patients with acute myeloid leukemia. Kuzmanovic M, Tosic N, Colovic N, Karan-Djurasevic T, Spasovski V, Radmilovic M, Nikcevic G, Suvajdzic-Vukovic N, Tomin D, Vidovic A, Virijevic M, Pavlovic S, Colovic M. Acta Haematol. 2012;128(4):203-12.

Clinical significance of genetic aberrations in secondary acute myeloid leukemia. Milosevic JD, Puda A, Malcovati L, Berg T, Hofbauer M, Stukalov A, Klampfl T, Harutyunyan AS, Gisslinger H, Gisslinger B, Burjanivova T, Rumi E, Pietra D, Elena C, Vannucchi AM, Doubek M, Dvorakova D, Robesova B, Wieser R, Koller E, Suvajdzic N, Tomin D, Tosic N, Colinge J, Racil Z, Steurer M, Pavlovic S, Cazzola M, Kralovics R. Am J Hematol. 2012 Nov;87(11):1010-6

Overexpression of the novel member of the BCL2 gene family, BCL2L12, is associated with the disease outcome in patients with acute myeloid leukemia. Thomadaki H, Floros KV, Pavlovic S, Tosic N, Gourgiotis D, Colovic M, Scorilas A. Clin Biochem. 2012 Nov;45(16-17):1362-7.

Reversal of FLT3 mutational status and sustained expression of NPM1 mutation in paired presentation, and relapse samples in a patient with acute myeloid leukemia. Radojkovic M, Tosic N, Colovic N, Ristic S, Pavlovic S, Colovic M. Ann Clin Lab Sci. 2012 Spring;42(2):186-90

Mutational status and gene repertoire of IGHV-IGHD-IGHJ rearrangements in Serbian patients with chronic lymphocytic leukemia. Karan-Djurasevic T, Palibrk V, Kostic T, Spasovski V, Nikcevic G, Srzentic S, Colovic M, Colovic N, Vidovic A, Antic D, Mihaljevic B, Pavlovic S, Tosic N. Clin Lymphoma Myeloma Leuk. 2012 Aug;12(4):252-60.

Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies. Puda A, Milosevic JD, Berg T, Klampfl T, Harutyunyan AS, Gisslinger B, Rumi E, Pietra D, Malcovati L, Elena C, Doubek M, Steurer M, Tosic N, Pavlovic S, Guglielmelli P, Pieri L, Vannucchi AM, Gisslinger H, Cazzola M, Kralovics R. Am J Hematol. 2012 Mar;87(3):245-50.

Central nervous system relapse in CD56+, FLT3/ITD+ promyelocytic leukemia. Colovic N, Tomin D, Vidovic A, Tosic N, Atkinson HD, Colovic MD. Med Oncol. 2012 Mar;29(1):260-2

Acute myeloid leukemia with NUP98-HOXC13 fusion and FLT3 internal tandem duplication mutation: case report and literature review. Tosić N, Stojiljković M, Colović N, Colović M, Pavlović S. Cancer Genet Cytogenet. 2009 Sep;193(2):98-103.

Incidence of FLT3 and nucleophosmin gene mutations in childhood acute myeloid leukemia: Serbian experience and the review of the literature. Krstovski N, Tosic N, Janic D, Dokmanovic L, Kuzmanovic M, Spasovski V, Pavlovic S. Med Oncol. 2010 Sep;27(3):640-5.

Clinical features of the most common fusion genes in childhood acute lymphoblastic leukemia. Lazic J, Tosic N, Dokmanovic L, Krstovski N, Rodic P, Pavlovic S, Janic D. Med Oncol. 2010 Jun;27(2):449-53.

Polymorphisms of tumor-necrosis factor-alpha - 308 and lymphotoxin-alpha + 250: possible modulation of susceptibility to apoptosis in chronic lymphocytic leukemia and non-Hodgkin lymphoma mononuclear cells. Jevtovic-Stoimenov T, Kocic G, Pavlovic D, Macukanovic-Golubovic L, Marjanovic G, Djordjevic V, Tosić N, Pavlović S. Leuk Lymphoma. 2008 Nov;49(11):2163-9.

Importance of early detection and follow-up of FLT3 mutations in patients with acute myeloid leukemia. Colovic N, Tosic N, Aveic S, Djuric M, Milic N, Bumbasirevic V, Colovic M, Pavlovic S. Ann Hematol. 2007 Oct;86(10):741-7.