Naučni savetnik
Laboratorija za molekularnu mikrbiologiju (LMM)

Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI),
Univerzitet u Beogradu,

V. Stepe 444a, 11010 Beograd, Srbija
Mob: +381 64 499 86 68
Tel: +381 11 397 59 60
Fax: +381 11 397 58 08
E-mail: mkojic@imgge.bg.ac.rs

OBRAZOVANJE

1995 - doktor bioloških nauka, Biološki fakultet, Univerzitet u Beogradu
1992 - magistar bioloških nauka, Biološki fakultet, Univerzitet u Beogradu
1987 - diplomirani biolog, Prirodno-matematički fakultet, Univerzitet u Beogradu

ISTRAŽIVAČKO ISKUSTVO

2007 - naučni savetnik, Institut za molekularnu genetiku i genetičko inženjerstvo, Univerzitet u Beogradu
2002 - 2007 - viši naučni savetnik, Institut za molekularnu genetiku i genetičko inženjerstvo, Univerzitet u Beogradu
1995 - 2002 - naučni saradnik, Institut za molekularnu genetiku i genetičko inženjerstvo, Univerzitet u Beogradu
1989 - 1995 - istraživač saradnik, Institut za molekularnu genetiku i genetičko inženjerstvo
1988 - 1989 - istraživač pripravnik, Institut za molekularnu genetiku i genetičko inženjerstvo

RADNO ISKUSTVO

2010 - rukovodilac Laboratorije za molekularnu mikrbiologiju (LMM)

OSTALE AKTIVNOSTI

2011 - član upravnog odbora IMGGI,
2010 - 2013 - predsednik naučnog veća IMGGI

OBLAST NAUČNOG INTERESOVANJA

Regulacija genske ekspresije u bakterijama: u pseudomonadama i bakterijama mlečne kiseline.
Kloniranje i ekspresija gena u homolognim i heterolognim sistemima za probiotička svojstva bakterija mlečne kiseline (produkcija bakteriocina, proteinaza serinskog tipa, agregacionih faktora I operona za sintezu egzopolisaharida.
Izučavanje interakcije molekula bakteriocina I receptora na membrani.
Izučavanje molekularnih mehanizama rezistencije na antibiotike u bakterijama.

ODABRANI NAUČNI RADOVI

Ovchinnikov KV, Kristiansen PE, Uzelac G, Topisirovic L, Kojic M, Nissen-Meyer J, Nes IF Diep DB., Defining the structure and receptor binding domain of the leaderless bacteriocin LsbB.
J Biol Chem. 2014 Aug 22;289(34):23838-45. doi: 10.1074/jbc.M114.579698.
PMID: 24993828
Lukic J, Strahinic I, Milenkovic M, Nikolic M, Tolinacki M, Kojic M, Begovic J.
Aggregation factor as an inhibitor of bacterial binding to gut mucosa.
Microb Ecol. 2014 Oct;68(3):633-44. doi: 10.1007/s00248-014-0426-1. Epub 2014 May 14.
PMID: 24823989

Uzelac G, Kojic M, Lozo J, Aleksandrzak-Piekarczyk T, Gabrielsen C, Kristensen T, Nes IF, Diep DB, Topisirovic L.
A Zn-dependent metallopeptidase is responsible for sensitivity to LsbB, a class II leaderless bacteriocin of Lactococcus lactis subsp. lactis BGMN1-5.
J Bacteriol. 2013 Dec;195(24):5614-21. doi: 10.1128/JB.00859-13. Epub 2013 Oct 11.
PMID: 24123824

Lukic J, Strahinic I, Milenkovic M, Golic N, Kojic M, Topisirovic L, Begovic J.
Interaction of Lactobacillus fermentum BGHI14 with rat colonic mucosa: implications for colitis induction.
Appl Environ Microbiol. 2013 Sep;79(18):5735-44. doi: 10.1128/AEM.01807-13. Epub 2013 Jul 12.
PMID: 23851097
Jovcic B, Lepsanovic Z, Begovic J, Rakonjac B, Perovanovic J, Topisirovic L, Kojic M.
The clinical isolate Pseudomonas aeruginosa MMA83 carries two copies of the blaNDM-1 gene in a novel genetic context.
Antimicrob Agents Chemother. 2013 Jul;57(7):3405-7. doi: 10.1128/AAC.02312-12. Epub 2013 Apr 22.
PMID: 23612199

Lukic J, Strahinic I, Jovcic B, Filipic B, Topisirovic L, Kojic M, Begovic J.
Different roles for lactococcal aggregation factor and mucin binding protein in adhesion to gastrointestinal mucosa.
Appl Environ Microbiol. 2012 Nov;78(22):7993-8000. doi: 10.1128/AEM.02141-12. Epub 2012 Sep 7.
PMID: 22961901

Nikolic M, Lopez P, Strahinic I, Suarez A, Kojic M, Ferna¡ndez-Garcia M, Topisirovic L, Golic N, Ruas-Madiedo P.
Characterisation of the exopolysaccharide (EPS)-producing Lactobacillus paraplantarum BGCG11 and its non-EPS producing derivative strains as potential probiotics.
Int J Food Microbiol. 2012 Aug 17;158(2):155-62. doi: 10.1016/j.ijfoodmicro.2012.07.015. Epub 2012 Jul 20.
PMID: 22858135

Kojic M, Jovcic B, Strahinic I, Begovic J, Lozo J, Veljovic K, Topisirovic L.
Cloning and expression of a novel lactococcal aggregation factor from Lactococcus lactis subsp. lactis BGKP1.
BMC Microbiol. 2011 Dec 19;11:265. doi: 10.1186/1471-2180-11-265.
PMID: 22182285
Jovcic B, Lepsanovic Z, Suljagic V, Rackov G, Begovic J, Topisirovic L, Kojic M.
Emergence of NDM-1 metallo-β-lactamase in Pseudomonas aeruginosa clinical isolates from Serbia.
Antimicrob Agents Chemother. 2011 Aug;55(8):3929-31. doi: 10.1128/AAC.00226-11. Epub 2011 Jun 6.
PMID: 21646490
Begovic J, Huys G, Mayo B, D'Haene K, Florez AB, Lozo J, Kojic M, Strahinic I, Topisirovic L.
Human vaginal Lactobacillus rhamnosus harbor mutation in 23S rRNA associated with erythromycin resistance.
Res Microbiol. 2009 Jul-Aug;160(6):421-6. doi: 10.1016/j.resmic.2009.07.005. Epub 2009 Jul 18.
PMID: 19619642

Lozo J, Jovcic B, Kojic M, Dalgalarrondo M, Chobert JM, Haertle T, Topisirovic L.
Molecular characterization of a novel bacteriocin and an unusually large aggregation factor of Lactobacillus paracasei subsp. paracasei BGSJ2-8, a natural isolate from homemade cheese.
Curr Microbiol. 2007 Sep;55(3):266-71. Epub 2007 Jul 25.
PMID: 17657532

Topisirovic L, Kojic M, Fira D, Golic N, Strahinic I, Lozo J.
Potential of lactic acid bacteria isolated from specific natural niches in food production and preservation.
Int J Food Microbiol. 2006 Dec 1;112(3):230-5. Epub 2006 Jun 9.
PMID: 16764959

Kojic M, Jovcic B, Vindigni A, Odreman F, Venturi V.
Novel target genes of PsrA transcriptional regulator of Pseudomonas aeruginosa.
FEMS Microbiol Lett. 2005 May 15;246(2):175-81.
PMID: 15899403

Aguilar C, Friscina A, Devescovi G, Kojic M, Venturi V.
Identification of quorum-sensing-regulated genes of Burkholderia cepacia.
J Bacteriol. 2003 Nov;185(21):6456-62.
PMID: 14563881

Pastar I, Tonic I, Golic N, Kojic M, van Kranenburg R, Kleerebezem M, Topisirovic L, Jovanovic G.
Identification and genetic characterization of a novel proteinase, PrtR, from the human isolate Lactobacillus rhamnosus BGT10.
Appl Environ Microbiol. 2003 Oct;69(10):5802-11.
PMID: 14532028

Gajic O, Buist G, Kojic M, Topisirovic L, Kuipers OP, Kok J.
Novel mechanism of bacteriocin secretion and immunity carried out by lactococcal multidrug resistance proteins.
J Biol Chem. 2003 Sep 5;278(36):34291-8. Epub 2003 Jun 11.
PMID: 12801935

Kojic M, Aguilar C, Venturi V.
TetR family member psrA directly binds the Pseudomonas rpoS and psrA promoters.
J Bacteriol. 2002 Apr;184(8):2324-30.
PMID: 11914368

Kojic M, Venturi V.
Regulation of rpoS gene expression in Pseudomonas: involvement of a TetR family regulator.
J Bacteriol. 2001 Jun;183(12):3712-20.
PMID: 11371535 [
Degrassi G, Kojic M, Ljubijankic G, Venturi V.
The acetyl xylan esterase of Bacillus pumilus belongs to a family of esterases with broad substrate specificity.
Microbiology. 2000 Jul;146 ( Pt 7):1585-91.
PMID: 10878123