Viši naučni saradnik
Laboratorija za molekularnu biomedicinu

Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI),
Univerzitet u Beogradu,

V. Stepe 444a, 11010 Beograd, Srbija
Mob:   +381 64 397 64 45
Tel:     +381 11 397 64 45
Fax:    +381 11 397 58 08
E-mail: maja.stojiljkovic@imgge.bg.ac.rs                                   

OBRAZOVANJE

2009 - Doktor bioloških nauka – molekularna biologija, Biološki fakultet (BF), Univerzitet u Beogradu (UB),
(Naslov teze: Polimorfizmi u genu za fenilalanin hidroksilazu čoveka kao regulatori genske ekspresije,
modulatori fenotipa i populaciono-genetički markeri)
2004 - Diplomirani molekularni biolog, BF, UB

ISTRAŽIVAČKO ISKUSTVO

2015 - viši naučni saradnik, IMGGI, UB
2010 - 2015
- naučni saradnik, IMGGI, UB
2007 - 2010 - istraživač saradnik, IMGGI, UB
2006 - 2007 - istraživač pripravnik, Institut za molekularnu genetiku i genetičko inženjerstvo, (IMGGI), UB

RADNO ISKUSTVO

2013 - rukovodilac potprojekta „Dissemination and promotion“ u okviru evropskog projekta „Strengthening the Research Potential of IMGGE through Reinforcement of Biomedical Science of Rare Diseases in Serbia – en route for innovation, SERBORDISinn“ (EU-FP7-REGPOT, 316088, 2013-2016)
2012 - 2013 - rukovodilac projekta „Molekularna osnova organskih acidurija u Srbiji i primena novih terapeutskih strategija baziranih na genotipu“ (bilateralnog projekta između Republike Srbije i Kraljevine Španije, 451-03-02635/2011-14/14, 2012-2013).
2011 - rukovodilac potprojekta „Uticaj gena- uzročnika i gena- modifikatora na varijabilnost kliničke slike i individualizaciju terapije kod pacijenata obolelih od naslednih retkih bolesti“ u okviru nacionalnog projekta „Retke bolesti: molekularna patofiziologija, dijagnostički i terapijski modaliteti i socijalni, etički i pravni aspekti“ (MPNTR, III 41004, 2011-2014)
2010 - zamenik šefa Laboratorije za molekularnu biomedicinu
2010 - predavač na doktorskim studijama na Biološkom fakultetu, UB, u okviru studijskog programa molekularna biologija (predmeti „Molekularna genetika u dijagnostici, prevenciji i terapiji bolesti čoveka“ i „Personalizovana medicina i farmakogenetika“)     
2010 - asistent koordinatora za Srbiju za ORPHANET (Zvanični evropski portal za retke bolesti, www.orpha.net)

OSTALE AKTIVNOSTI           

2014 - član predsedništva ICORD-a (International Conference on Rare Disease and Orphan Drugs, www.icord.se)
2010 - član Stručnog saveta NORBS-a (Nacionalna organizacija za retke bolesti Srbije, www.norbs.rs)

OBLAST NAUČNOG INTERESOVANJA

Istraživanja u oblasti molekularne biomedicine sa fokusom na retke bolesti. Do sada, izučavala je genetičku osnovu nekoliko retkih bolesti u srpskoj populaciji, optimizujući metode za detekciju mutacija i stvarajući osnovu za molekularnu dijagnostiku (fenilketonurija, tetrahidrobiopterin deficijencije, organske acidurije, talasemije kongenitalna adrenalna hiperplazija itd). Posebnu pažnju posvećuje funkcionalnoj karakterizaciji novootkrivenih genetičkih varijanti (studije transkripcione ekspresije i studije proteinske stabilnosti i aktivnosti) radi što potpunijeg razumevanja korelacije genotipa i fenotipa određenih retkih bolesti, predikcije težine bolesti i predikcije efikasnosti specifičnih lekova na osnovu genotipa obolelog (npr. primena leka „Kuvan“ kod pacijenata sa fenilketonurijom).

ODABRANI NAUČNI RADOVI

Stojiljkovic M, Klaassen K, Pavlovic S. Molecular characteristics, phenotypic diversity and genotype-estimated therapeutic responsiveness of Serbian patients with phenylketonuria. J Med Biochem 2014; 33: 97-107. Review article

Pavlovic S, Zukic B, Stojiljkovic M.  Molecular genetic markers as a basis for personalized medicine. J Med Biochem 2014; 33: 8-21. Review article

Klaassen K, Djordjevic M, Stojiljkovic M, Pavlovic S. Association of mitochondrial DNA variants and cognitive impairment of PKU patients. J Med Biochem 32: 337–343, 2013.

Tafrali C, Paizi A, Borg J, Radmilovic M, Bartsakoulia M, Giannopoulou E, Giannakopoulou O, Stojiljkovic M, Zukic B, Poulas K, Stavrou EF, Lambropoulou P, Kourakli A, Felice AE, Papachatzopoulou A, Philipsen S, Pavlovic S, Georgitsi M, Patrinos GP. Genomic variations in the MAP3K5 gene is associated with beta-thalassemia disease severity and hydroxyurea treatment efficacy. Pharmacogenomics 2013; 14(5): 469-83. https://www.ncbi.nlm.nih.gov/pubmed/23556445

Radmilovic M, Zukic B, Stojiljkovic M, Bartsakoulia M, Stankovic B, Kotur N, Dokmanovic L, Georgitsi M, Patrinos G, Pavlovic S. Functional analysis of a novel KLF1 gene promoter variation associated with hereditary persistence of fetal hemoglobin. Annals of Hematology 2013; 92(1): 53-8. https://www.ncbi.nlm.nih.gov/pubmed/23161389

Spasovski V, Tosic N, Nikcevic G, Stojiljkovic M, Zukic B, Radmilovic M, Karan – Djurasevic T, Srzentic S, Colovic M, Pavlovic S. The influence of novel transcriptional regulatory element in intron 14 on expression of Janus kinase 2 gene in myeloproliferative neoplasms. J Appl Genet 2013; 54(1): 21-6. https://www.ncbi.nlm.nih.gov/pubmed/23188718

Djordjevic M, Klaassen K, Sarajlija A, Tosic N, Zukic B, Kecman B, Ugrin M, Spasovski V, Pavlovic S, Stojiljkovic M. Molecular genetics and genotype based estimation of BH4-responsiveness in Serbian PKU patients: spotlight on phenotypic implications of p.L48S. J Inherit Metab Dis Reports 2013; 9: 49-58. doi: 10.1007/8904_2012_178. https://www.ncbi.nlm.nih.gov/pubmed/23430547

Kotur N, Stankovic B, Kassela K, Georgitsi M, Vicha A, Dokmanovic L, Janic D, Krstovski N, Klaassen K, Radmilovic M, Stojiljkovic M, Nikcevic G, Simeonidis A, Sivolapenko G, Pavlovic S, Patrinos GP, Zukic B. Six-mercaptopurine influences TPMT gene transcription in a TPMT gene promoter variable number of tandem repeats-dependent manner. Pharmacogenomics 2012: 13(3):283-95. https://www.ncbi.nlm.nih.gov/pubmed/22304581

Stojiljkovic M, Fazlagic A, Krivokapic-Dokmanovic L, Nikcevic G, Patrinos GP, Pavlovic S, Zukic B. 6th Golden Helix Pharmacogenomics Day: pharmacogenomics and individualized therapy. Hum Genomics. 2012; 6(1): 19. https://www.ncbi.nlm.nih.gov/pubmed/23157848

Stojiljkovic M, Patrinos G, Pavlovic S. Clinical Applicability of Sequence Variations in Genes Related to Drug Metabolism. Curr Drug Metab 2011: 12 (5): 445-454. https://www.ncbi.nlm.nih.gov/pubmed/21453274

Giardine B, Borg J, Higgs D, Peterson K, Philipsen S, Maglott D, Singleton B, Anstee D, Basak AN, Clark B, Costa F, Faustino P, Fedosyuk H, Felice A, Francina A, Galanello R, Gallivan M, Georgitsi M, Gibbons R, Giordano P, Harteveld C, Hoyer J, Jarvis M, Joly P, Kanavakis E, Kollia P, Menzel S, Miller W, Moradkhani K, Old J, Papachatzopoulou A, Papadakis M, Papadopoulos P, Pavlovic S, Perseu L, Radmilovic M, Riemer C, Satta S, Schrijver I, Stojiljkovic M, Thein SL, Traeger-Synodinos J, Tully R, Wada T, Waye J, Wiemann C, Zukic B, Chui D, Wajcman H, Hardison R, Patrinos P. Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach. Nat Genet 2011: 43(4): 295-301. https://www.ncbi.nlm.nih.gov/pubmed/21423179

Stojiljkovic M, Zukic B, Tosic N, Karan Djurasevic T, Spasovski V, Nikcevic G, Pavlovic S. Novel transcriptional regulatory element in the phenylalanine hydroxylase gene intron 8. Mol Genet Metab 2010: 101: 81-83. https://www.ncbi.nlm.nih.gov/pubmed/20599406

Zukic B, Radmilovic M, Stojiljkovic M, Tosic N, Pourfarzad F, Dokmanovic L, Janic D, Colovic N, Philipsen S, Patrinos G, Pavlovic S. Functional analysis of the role of the TPMT gene promoter VNTR polymorphism in TPMT gene transcription. Pharmacogenomics 2010: 11: 547-557. https://www.ncbi.nlm.nih.gov/pubmed/20350137

Radmilovic M, Zukic B, Stankovic B, Karan-Djurasevic T, Stojiljkovic M, Spasovski V, Tosic N, Dokmanovic L, Janic D, Pavlovic S. Thalassemia Syndromes in Serbia: An update. Hemoglobin 2010: 34 (5): 477-85. https://www.ncbi.nlm.nih.gov/pubmed/20854122

Pavlovic S, Stojiljkovic M. Molecular Diagnosis of Phenylketonuria: From Defective Protein to Disease-Causing Gene Mutation. J Med Biochem 2009: 28 (4): 262-287.

Tosic N, Stojiljkovic M, Colovic N, Colovic M, Pavlovic S. Acute Myeloid Leukemia with NUP98-HOXC13 Fusion and FLT3-ITD Mutation: Case Report and Review of the Literature. Cancer Genet Cytogenet 2009: 193 (2): 98-103. https://www.ncbi.nlm.nih.gov/pubmed/19665070

Stojiljkovic M, Perez B, Desviat LR, Aguado C, Ugarte M, Pavlovic S. The Missense p.S231F Phenylalanine Hydroxylase Gene Mutation Causes Complete Loss of Enzymatic Activity In Vitro. Protein J: 2009 28: 294. https://www.ncbi.nlm.nih.gov/pubmed/19629656

Stojiljkovic M, Stevanovic A, Djordjevic M, Petrucev B, Tosic N, Karan Djurasevic T, Aveic S, Radmilovic M, Pavlović S. Mutations in the PAH gene: a tool for population genetic study. Arch Biol Sci 2007: 59 (3): 161-167.

Stojiljkovic M, Jovanovic J, Djordjevic M, Grkovic S, Cvorkov Drazic M, Petrucev B, Tosic N, Karan Djurasevic T, Stojanov Lj, Pavlovic S. Molecular and phenotypic characteristics of phenylketonuria patients in Serbia and Montenegro. Clin Genet 2006: 70: 151-155. https://www.ncbi.nlm.nih.gov/pubmed/16879198