Lidija Šenerović

Viši naučni saradnik
Laboratorija za molekularnu genetiku i ekologiju mikroorganizama (LMGEM)

Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI),
Univerzitet u Beogradu (UB)

Vojvode Stepe 444a, P. Fah 23, 11010 Beograd, Srbija
Mob:   +381 65 397 60 34  
Tel:     +381 11 397 60 34
Fax:    +381 11 397 58 08
E-mail: seneroviclidija@imgge.bg.ac.rs

OBRAZOVANJE

2009 - Doktor bioloških nauka (specijalizacija: biohemija), Humboldt Univerzitet, Berlin, Nemačka
(TEZA: Funkcionalna i strukturna karakterizacija virulentnog faktora IpaB iz Shigella flexneri)
2005 - Magistar bioloških nauka, Biološki fakultet, UB
2001 - Diplomirani molekularni biolog i fiziolog, Biološki fakultet, UB

ISTRAŽIVAČKO ISKUSTVO

2016 - Viši naučni saradnik, Laboratorija za molekularnu genetiku i ekologiju mikroorganizama, IMGGI, UB
2011 - 2016
- Naučni saradnik, Laboratorija za molekularnu genetiku i ekologiju mikroorganizama, IMGGI, UB
2006 - 2009 - Doktorand u Laboratoriji za ćelijsku mikrobiologiju, Max Planck Institut za infektivnu biologiju, Berlin, Nemačka
2005 - 2006 - Istraživač saradnik, Laboratorija za molekularnu biotehnologiju, IMGGI, UB
2002 - 2005 - Istraživač pripravnik, Laboratorija za molekularnu biotehnologiju, IMGGI, UB

OBLAST NAUČNOG INTERESOVANJA

  • Proizvodnja i karakterizacija bioaktivnih jedinjenja sa antibakterijskim i antigljivičnim aktivnostima;
  • Novi pristupi u antimikrobiološkim tretmanima (novi molekuli koji modulišu mikrobiološku komunikaciju; agensi koji modulišu virulenciju i sprečavaju formiranje biofilmova bakterija i gljiva);
  • Domaćin-patogen interakcije;
  • Razvoj novih i efikasnijih terapeutika korišćenjem nano-nosača.

ODABRANI NAUČNI RADOVI

Aleksic I., Petkovic M., Jovanovic M., Milivojevic D., Vasiljevic B., Nikodinovic-Runic J.  and  Senerovic L. (2017). Anti-biofilm properties of bacterial di-rhamnolipids and their semi-synthetic amide derivatives. Microbiol Front Microbiol 8;8:2454 https://www.frontiersin.org/articles/10.3389/fmicb.2017.02454/full 

Aleksić I., Šegan S., Andrić F., Zlatović M., Moric I., Opsenica D. and Senerovic L. (2017). Long-chained 4-Aminoquinolines as quorum sensing inhibitors in Serratia marcescens and Pseudomonas aeruginosa. ACS Chem Biol 12(5):1425-1434 https://www.ncbi.nlm.nih.gov/pubmed/28350449 

Pekmezovic M., Aleksic I., Barac A., Arsic-Arsnijevic V., Vasiljevic B., Nikodinovic-Runic J. and Senerovic L. (2016). Prevention of polymicrobial biofilms composed of Pseudomonas aeruginosa and pathogenic fungi by essential oils from selected Citrus species. Pathog Dis (2016) 74 (8): ftw102. https://www.ncbi.nlm.nih.gov/pubmed/27702795 

Ajdačić V., Senerovic L., Pekmezovic M., Arsic-Arsnijevic V., Veselinovic A., Veselinovic J., Šolaja B. A., Nikodinovic-Runic J. and Opsenica I.M. (2016). Synthesis and evaluation of thiophene-based guanylhydrazones (iminoguanidines) efficient against panel of voriconazole-resistant fungal isolates. Bioorg Med Chem 24(6): 1277-1291. http://www.ncbi.nlm.nih.gov/pubmed/26867487

Glišić B., Senerovic L., Comba P., L., Wadepohl, H., Veselinovic A., Milivojevic, D., Djuran, M. and Nikodinovic-Runic J. (2016). Silver (I) Complexes with Phthalazine and Quinazoline as Effective Agents against Pathogenic Pseudomonas aeruginosa Strains. Journal of Inorganic Biochemistry 155: 115–128. http://www.ncbi.nlm.nih.gov/pubmed/26687023 

Savic, N., Glisic, BDj., Wadepohl, H., Pavic, A., Senerovic,L., Nikodinovic-Runic, J. and Djuran, M. (2015). Silver(I) complexes with quinazoline and phthalazine: synthesis, structural characterization and evaluation of biological activities. Med Chem Comm 7: 282-291. http://pubs.rsc.org/en/content/articlelanding/2016/md/c5md00494b - !divAbstract 

Milisavljevic M., Zivkovic S., Pekmezovic M., Stankovic N., Vojnovic S., Vasiljevic B. and Senerovic L. (2015). Control of human and plant fungal pathogens using pentaene macrolide 32, 33- didehydroroflamycoin (DDHR). J Appl Micro 118(6):1426-34 http://www.ncbi.nlm.nih.gov/pubmed/25810243

Senerovic L., Zivkovic M.D., Veselinovic A., Pavic A., Djuran M.I., Rajkovic S., Nikodinovic-Runic J. (2015). Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes. J Med Chem. 58 (3):1442-51. http://pubs.acs.org/doi/ipdf/10.1021/jm5017686

Nikodinovic-Runic J., Mojic M., Kang Y., Maksimovic-Ivanic D., Mijatovic S., Vasiljevic B., Stamenkovic V., Senerovic L. (2014). Undecylprodigiosin conjugated monodisperse gold nanoparticles efficiently cause apoptosis in colon cancer cells in vitro. J Mater Chem B 2 (21), 3271 - 3281. http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/c4tb00300d#!divAbstract

Stankovic, N., Senerovic, L., Ilic-Tomic, T., Vasiljevic, B., Nikodinovic-Runic, J. (2014). Properties and applications of undecylprodigiosin and other bacterial prodigiosins. Applied Microbiology and Biotechnology. 98, 3841-3858. http://www.ncbi.nlm.nih.gov/pubmed/24562326

Stankovic, N., Senerovic, L., Bojic-Trbojevic, Z., Vuckovic, I., Vicovac, L., Vasiljevic, B., Nikodinovic-Runic, J. (2013). Didehydroroflamycoin (DDHR) pentaene macrolide family from Streptomyces durmitorensis MS405: Production optimization and antimicrobial activity. Journal of Applied Microbiology. 115, 1297-1306. http://www.ncbi.nlm.nih.gov/pubmed/23941529 

Mounier J., Boncompain G., Senerovic L., Perez F.,  Lagache T, Chrétien F, Kolbe M., Olivo-Marin JC., Sansonetti P.J. and Sauvonnet N. (2012): Shigella effector IpaB-induced cholesterol relocation disrupts the golgi complex and recycling network to inhibit host cell secretion, Cell Host Microbe. Sep 13;12(3):381-9. http://www.ncbi.nlm.nih.gov/pubmed/22980334

Senerovic L., Tsunoda S., Goosmann C., Brinkmann V., Zychlinsky A., Meissner F. and Kolbe M. (2012): Spontaneous formation of IpaB ion channels in host cell membranes reveals how Shigella induces pyroptosis in macrophages Cell Death Dis. Sep 6;3:e384. http://www.ncbi.nlm.nih.gov/pubmed/22951981

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