Naučni savetnik
Laboratorija  za molekularnu biologiju (LMB)

Institut za molekularnu genetiku i genetičko inženjerstvo (IMGGI),
Univerzitet u Beogradu,

V. Stepe 444a, 11010 Beograd, Srbija
Mob:   +381 64 8044083
Tel:     +381 11 3976658
Fax:    +381 11 397 58 08
E-mail: dada@imgge.bg.ac.rs                                   

OBRAZOVANJE

1997 - Doktor bioloških nauka, Biološki fakultet (BF), Univerzitet u Beogradu (UB),
(Teza: Prenatalna dijagnostika cistične fibroze primenom metoda ekombinantne DNK)
1986 - Magistar bioloških nauka, BF, UB
1982 - Diplomirani molekularni biolog, PMF, UB

ISTRAŽIVAČKO ISKUSTVO

2007 - naučni savetnik, IMGGI
2001 - 2007 - viši naučni saradnik, IMGGI
2000 - 2005 - post doktorant u Department of Human Genetics, KUL, Belgija
1998 - 2001 - naučni  saradnik, IMGGI
1994 - 1997 - istraživač saradnik, IMGGI
1984 - 1994 - istraživač pripravnik, Institut za zdravstvenu zaštitu majke i deteta, RS

RADNO ISKUSTVO

2010 - rukovodilac  LMB, IMGGI
2007 - član programskog saveta, coordinator predmeta i predavač na doktorskimstudijama na Biološkom fakultetu, UB,
u okviru studijskog programa doktorskih studija, modul Molekularna biologija
2005 - rukovodilac projekta, LMB, IMGGI, UB
2000 - 2005 - post doktorant  u Department  for human genetics, KUL, Belgium
1994 - 2000 - LMB, IMGGI
1984 - 1994 - Laboratorija za medicinsku genetiku Instituta za zdravstvenu zaštitu majke i deteta, RS           

OSTALE AKTIVNOSTI

2011 - 2014 - član Republičke komisije  za sticanje  naučnih zvanja, Ministarstvo prosvete, nauke I tehnološkog razvoja RS
2008 - Predstavnik  RS u EPMA
2006 - nacionalni koordinator za ORPHANET-a
Član Srpskog biološkog društva, Društva genetičara Srbije, Biohemijskog društva Srbije, Genomic Medicine Alliance, ESHG, ECFS.        

OBLAST NAUČNOG INTERESOVANJA

Humana molekularna genetika, medicinska genetika, geni modifikatori u modulaciji fenotipa, genska ekspresija, strukturalna i funkcionalna analiza nekodirajućih regiona DNK, biomarkeri, personalizovana medicina, farmakogenetika, prediktivna i preventivna neinvazivna dijagnostika, javno zdravlje

ODABRANI NAUČNI RADOVI

Petrovic-Stanojevic N, Topic A, Nikolic A, Stankovic M, Dopudja-Pantic V, Milenkovic B, Radojkovic D. Polymorphisms of Beta2-Adrenergic Receptor Gene in Serbian Asthmatic Adults: Effects on Response to Beta-Agonists. Mol Diagn Ther. 2014 Jul 30 PMID: 2507450, http://www.ncbi.nlm.nih.gov/pubmed/25074500

Ljujic M, Divac Rankov A, Kojic S, Miranda E, Radojkovic D.Functional analysis of novel alpha-1 antitrypsin variants G320R and V321F. Mol Biol Rep. 2014 Sep;41(9):6133-41. http://www.ncbi.nlm.nih.gov/pubmed/24969485

Nikolic A, Radlovic N, Dinic J, Milosevic K, Radojkovic D.Clinical presentation of mild cystic fibrosis in a Serbian patient homozygous for the CFTR mutation c.1393-1G>A.J Cyst Fibros. 2014 Jan;13(1):111-3. http://www.ncbi.nlm.nih.gov/pubmed/23933162

Djordjevic V, Kovac M, Miljic P, Murata M, Takagi A, Pruner I, Francuski D, Kojima T, Radojkovic D,A novel prothrombin mutation in two families with prominent thrombophilia - the first cases of antithrombin resistance in a Caucasian population. J Thromb Haemost. 2013 Oct;11(10):1936 http://www.ncbi.nlm.nih.gov/pubmed/23927452

Mendizabal I, Lao O, Marigorta UM, Wollstein A, Gusmão L, Ferak V, Ioana M, Jordanova A, Kaneva R, Kouvatsi A, Kučinskas V, Makukh H, Metspalu A, Netea MG, de Pablo R, Pamjav H, Radojkovic D, Rolleston SJ, Sertic J, Macek M Jr, Comas D, Kayser M. Reconstructing the population history of European Romani from genome-wide data. Curr Biol. 18; 22(24):2342-9. http://www.ncbi.nlm.nih.gov/pubmed/23219723

Topic A, Francuski D, Markovic B, Stankovic M, Dobrivojevic S, Drca S, Radojkovic D  Gender-related reference intervals of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine determined by liquid chromatography-tandem mass spectrometry in Serbian population. Clin Biochem. 2013,46 (4-5):321-6http://www.ncbi.nlm.nih.gov/pubmed/23261837

Kovac MK, Rakicevic LB, Kusic-Tisma JS, Radojkovic DP. Pharmacogenetic tests could be helpful in predicting of VKA maintenance dose in elderly patients at treatment initiation.J Thromb Thrombolysis 2013, 35 (1):90-4.http://www.ncbi.nlm.nih.gov/pubmed/22763922

Topic A, Stankovic M, Divac-Rankov A, Petrovic-Stanojevic N, Mitic-Milikic M, Nagorni-Obradovic L, Radojkovic D. Alpha-1-antitrypsin deficiency in Serbian adults with lung diseases. Genet Test Mol Biomarkers 2012, 16(11):1282-6 http://www.ncbi.nlm.nih.gov/pubmed/22971141

Stanke F, Becker T, Kumar V, Hedtfeld S, Becker C, Cuppens H, Tamm S, Yarden J, Laabs U, Siebert B, Fernandez L, Macek M Jr, Radojkovic D, Ballmann M, Greipel J, Cassiman JJ, Wienker TF, Tümmler B. Genes that determine immunology and inflammation modify the basic defect of impaired ion conductance in cystic fibrosis epithelia. J Med Genet. 2011,48(1):24-31http://www.ncbi.nlm.nih.gov/pubmed/20837493

Nikolic A, Kojic S, Knezevic S, Krivokapic Z, Ristanovic M, Radojkovic D Structural and functional analysis of SMAD4 gene promoter in malignant pancreatic and colorectal tissues: detection of two novel polymorphic nucleotide repeats.Cancer Epidemiol 2011, 35(3):265-71http://www.ncbi.nlm.nih.gov/pubmed/21036691

Bombieri C, Claustres M, De Boeck K, Derichs N, Dodge J, Girodon E, Sermet I, Schwarz M, Tzetis M, Wilschanski M, Bareil C, Bilton D, Castellani C, Cuppens H, Cutting GR, Drevínek P, Farrell P, Elborn JS, Jarvi K, Kerem B, Kerem E, Knowles M, Macek M Jr, Munck A, Radojkovic D, Seia M, Sheppard DN, Southern KW, Stuhrmann M, Tullis E, Zielenski J, Pignatti PF, Ferec CRecommendations for the classification of diseases as CFTR-related disorders  J Cyst Fibros.2011, 10 Suppl 2:S86-102.http://www.ncbi.nlm.nih.gov/pubmed/21658649

Kojic S, Radojkovic D, Faulkner G  Muscle ankyrin repeat proteins: their role in striated muscle function in health and disease.Crit Rev Clin Lab Sci. 2011,48(5-6):269-94.http://www.ncbi.nlm.nih.gov/pubmed/22185618

Castellani C, Cuppens H, Macek M Jr, Cassiman JJ, Kerem E, Durie P, Tullis E, Assael BM, Bombieri C, Brown A, Casals T, Claustres M, Cutting GR, Dequeker E, Dodge J, Doull I, Farrell P, Ferec C, Girodon E, Johannesson M, Kerem B, Knowles M, Munck A, Pignatti PF, Radojkovic D, Rizzotti P, Schwarz M, Stuhrmann M, Tzetis M, Zielenski J, Elborn JS  Consensus on the use and interpretation of cystic fibrosis mutation analysis in clinical practice. J Cyst Fibros. 2008,7(3):179-96. http://www.ncbi.nlm.nih.gov/pubmed/18456578

Stanke F, Becker T, Cuppens H, Kumar V, Cassiman JJ, Jansen S, Radojkovic D, Siebert B, Yarden J, Ussery DW, Wienker TF, Tummler B. The TNFalpha receptor TNFRSF1A and genes encoding the amiloride-sensitive sodium channel ENaC as modulators in cystic fibrosis. Hum Genet. 2006,119 (3):331-43 http://www.ncbi.nlm.nih.gov/pubmed/16463024

Yarden J, Radojkovic D, De Boeck K, Macek Jr M, Zemkova D, Vavrova V, Vlietinck R, Cassiman J-J, Cuppens H Association of tumour necrosis factor alpha variants with the CF pulmonary phenotype Thorax 2005, 60(4): 320–325http://www.ncbi.nlm.nih.gov/pubmed/15790988

Yarden J, Radojkovic D, De Boeck K, Macek Jr M, Zemkova D, Vavrova V, Viletinck R, Cassiman J-J, Cuppens H. Polymorphisms in the mannose binding lectin gene affect the cystic fibrosis pulmonary phenotype J Med Genet. 2004, 41: 629-633  http://www.ncbi.nlm.nih.gov/pubmed/15286159

Miković D., Lj.Rakićević,  M.Kovač,  . The Incidence of Factor V Leiden in Yugoslav Thrombophilic Patients and Its Relationship to the Laboratory Diagnosis of APC Resistance. Thrombosis and hemostasis 2000, 84, 823-824  http://www.ncbi.nlm.nih.gov/pubmed/11057877                                                                             

Kušić J., Radojkovic D., Cuppens H., Jaspers M., Tomić J, Savić A.  Identification of a novel mutation 525delT in exon 4 of CFTR gene in patient with cystic fibrosis, Human Mutation, 1999, 14/4,357http://www.ncbi.nlm.nih.gov/pubmed/10502789

Brukner Dabovic,B., , P.Minic, J.Savic and A.Savic Frequency of the  F508 deletion and G551D, R553X and G542X mutations in Yugoslav CF patients , Hum.Genet. 1992, 88, 699-700http://www.ncbi.nlm.nih.gov/pubmed/1551678