Research Associate

Institute of Molecular Genetics and Genetic Engineering (IMGGE),
University of Belgrade

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mobile:  +381 65  397 64 45                         
Phone:  +381 11 397 64 45
Fax:      +381 11 397 58 08
E-mail: tatjana.kostic@imgge.bg.ac.rs

EDUCATION

2001 - PhD in Molecular Genetics and Genetic Engineering, Faculty of Biology (FB), UB (Molecular basis of genetic rearrangements induced by IS5 elements in polA1 mutator strain of Escherichia coli K12)

1990 - M.Sc. in Molecular Genetics and Genetic Engineering, FB, UB

1985 - B.Sc. in Biology, FB, University of Belgrade

RESEARCH EXPERIENCE

2011 - Research Associatein Laboratory for Molecular Biomedicine IMGGE

2009 - 2011 - Research Associate,IMGGE

2001 - 2007 - Research Associate, IMGGE

1990 - 2001 - Research Assistant, IMGGE

1986 - 1990 - Research Assistant, IMGGI

CAREER HISTORY

2013 - Laboratory for Molecular Biomedicine, IMGGE

2003 - 2013 - Laboratory for Molecular Hematology,IMGGE

2001 - 2003 - Laboratory for Molecular Engineering of Microorganisms, IMGGE

1999 - 2000 - Laboratory of  Biochemistry and Molecular Biology,University of Cordoba, Spain

1996 - 1999 - Laboratory for Molecular Genetics of Procariota, IMGGE

1994 - 1996 - Laboratory of Biochemistry and Molecular Biology, University of Cordoba, Spain

1986 - 1993 - Laboratory for Molecular Genetics of Prokariota, IMGGE

RESEARCH INTEREST

Leukemia is a cancer of blood and bone marrow. AML (acute mieloide leukemia) is a cancer of the mieloide line of white blood cells, this is the most common acute leukemia affecting adults – its incidence increses with age. Translocations t(8;21), t(15;17) and inversion inv(16) are the most frequente genetic abnormality in AML  having  a prognostic significance. Translocation t(15;17) is subtype of AML named APL (acute promielocyte leukemia). The product of this translocation is a hybrid protein PML/RAR α, transcription factor  with altered function. Definitive diagnosis requires testing for the PML/RARα fusion gene - this may be done by PCR, FISH or conventional cytogenetics. The sensitivity of PCR method is 10⁻⁶. PML/RARα fusion protein  is used as a molecular target for ATRA –all trans retinoid acid- in therapy APL.

SELECTED PUBLICATIONS

                 

Rodic P, Pavlovic S, Kostic T, Suvajdzic Vukovic N, Djordjevic M, Sumarac Z, Dajak M, Bonaci Nikolic B, Janic D. Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease. Blood Cells Mol Dis. 2013 50: 222-22

H. Steingrimsdottir, D. Beare, J. Cole, J.F.M. Leal, T. Kostć, J. Lopez-Barea, G. Dorado, A.R. Lehman, (1996). Development of new molecular procedures for the detection of genetic alterations in man. Mutation Research, 353: 109-121.

JovanovicG., T. Kostić, M. Janković and D. Savić, (1994). Nucleotide sequence of the  Escherichia coli  K-12 histidine operon revisited. J.Mol.Biol., 239: 433-435.Gammopathy and B lymphocyte clonality in patients with Gaucher type... - PubMed - NCBI

Janković, M., T. Kostić and D.Savić, (1990). DNA sequence analysis of spontaneus histidine mutation in polA1 strain of Escherichia coli  K-12 suggests a specific role of the GTGG sequenc. Molecular & General Genetics, 223: 481-486.

Jovanović G., T. Kostić and D. Savić, (1990). Nucleotide and amino acid polymorphism in the gene for L-histidinol dehidrogenase of Escherichia coli  K-12. Nucl. Acids Res., 18: 33634.

 Savić, D., M. Janković and T. Kostić, (1990). Cellular role of DNA polymerase I. Journal of Basic Microbiology, 30(1990)10, 769-784.