Snežana Kojić

Principal Research Fellow
Laboratory for Molecular Biology

Institute of Molecular Genetics and Genetic Engineering (IMGGE),
University of Belgrade (UB)

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mobile:           +381 65 397 66 58                          
Phone:           +381 11 397 66 58
Fax:               +381 11 397 58 08
E-mail: snezanakojic@imgge.bg.ac.rs

EDUCATION

2003 - PhD in Molecular Biology, Faculty of Biology (FB), UB (Characterization of human muscle protein Ankrd2)
1998 - M.Sc. in Molecular Biology, FB, UB
1991 - B.Sc. in Molecular Biology, FB, UB

RESEARCH EXPERIENCE

2017 - Principal Research Fellow, LMB, IMGGE
2012 - 2017 - Senior Research Associate, Laboratory for Molecular Biology (LMB), IMGGE
2003 - 2012 - Research Associate LMB,IMGGE
1993 – 2003 - Research Assistant LMB, IMGGE
1992 - 1993 - Research Trainee, LMB, IMGGE

RESEARCH INTEREST

The main scientific interest focuses on the deciphering molecular mechanisms underlying neuromuscular disorders and cardiomyopathies. Particularly the studies are oriented to functional characterization of muscle ankyrin repeat stress sensors Ankrd1 and Ankrd2 which link the elastic I-band region of the sarcomere with transcriptional control in the nucleus. The work aims at identification of signaling pathways in which they have a pivotal role, their potential targets, as well as regulators of their expression in order to explore biological functions and regulatory role of Ankrd1 and Ankrd2 in striated muscles, using different animal model systems (zebrafish, chicken).

SELECTED PUBLICATIONS

  1. Jasnic-Savovic J, Krause S, Savic S, Kojic A, Kovcic V, Boskovic S, Nestorovic A, Rakicevic L, Schreiber-Katz O, Vogel JG, Schoser BG, Walter MC, Valle G, Radojkovic D, Faulkner G, Kojic S. (2016). Differential expression and localization of Ankrd2 isoforms in human skeletal and cardiac muscles. Histochemistry and Cell Biology, 146(5):569-584. https://www.ncbi.nlm.nih.gov/pubmed/27393496
  2. Jasnic-Savovic J, Nestorovic A, Savic S, Karasek S, Vitulo N, Valle G, Faulkner G, Radojkovic D and Kojic S. (2015). Profiling of skeletal muscle Ankrd2 protein in human cardiac tissue and neonatal rat cardiomyocytes. Histochemistry and Cell Biology, 143(6):583-597. https://www.ncbi.nlm.nih.gov/pubmed/25585647
  3. Martinelli V, Buck Kyle W, Kojic S, Vitulo N, Li Z, Belgrano A, Maiuri P, Banks L, Vatta M, Valle G, Faulkner G. (2014). ZASP interacts with the mechanosensing protein Ankrd2 and p53 in the signalling network of striated muscle. PLoS One, e92259. http://www.ncbi.nlm.nih.gov/pubmed/24647531
  4. Kojic S, Radojkovic D, Faulkner G. (2011). Muscle ankyrin repeat proteins: their role in striated muscle function in health and disease. Critical Reviews in Clinical Laboratory Sciences, 48(5-6): 269–294. http://www.ncbi.nlm.nih.gov/pubmed/22185618
  5. Belgrano A, Rakicevic L, Mittempergher L, Campanaro S, Martinelli VC, Mouly V, Valle G, Kojic S, Faulkner G. (2011). Multi-tasking role of the mechanosensing protein Ankrd2 in the signaling network of striated muscle. PLoS ONE, 6(10), e25519. http://www.ncbi.nlm.nih.gov/pubmed/22016770
  6. Kojic S, Nestorovic A, Rakicevic Lj, Belgrano A, Stankovic M, Divac A and Faulkner G. (2010). A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein. Archives of Biochemistry and Biophysics, 502, 60-67. http://www.ncbi.nlm.nih.gov/pubmed/20599664
  7. Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G. (2004). The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle. J Mol Biol, 339, 313-325 http://www.ncbi.nlm.nih.gov/pubmed/15136035
  8. Pallavicini A, Kojic S, Bean C, Vainzof M, Salamon M, Ievolella C, Bortoletto G, Pacchioni B, Zatz M, Lanfranchi G, Faulkner G, Valle G. (2001). Characterization of human skeletal muscle Ankrd2. Biochem Biophys Res Commun, 285, 378-386. http://www.ncbi.nlm.nih.gov/pubmed/11444853
  9. Faulkner G, Pallavicini A, Comelli A, Salamon M, Bortoletto G, Ievolella C, Trevisan S, Kojic S, Dalla Vecchia F, Laveder P, Valle G, Lanfranchi G. (2000). FATZ, a filamin-, actinin- and telethonin-binding protein of the Z-disc of skeletal muscle. J Biol Chem, 275, 41234-41242. http://www.ncbi.nlm.nih.gov/pubmed/10984498

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