Nataša Kovačević Grujičić

Research Associate
Laboratory for Human Molecular Genetics

Institute of Molecular Genetics and Genetic Engineering (IMGGE),
University of Belgrade

V. Stepe 444a, P.Box 23, 11010 Belgrade, Serbia
Mobile:   +381 65  3976212                           
Phone:   +381 11 3976212
Fax:       +381 11 397 58 08
E-mail: natasakovacevic@imgge.bg.ac.rs

EDUCATION

2009 - PhD in Biological Sciences, Faculty of Biology (FB), UB (“Characterization of the basal promoter of the human SOX3 gene and identification of the regulatory elements responsible for the SOX3 gene induction by retinoic acid“)
2000 - M.Sc. in Biological Sciences, FB, UB
1996 - B.Sc. in Molecular Biology and Physiology, FB, University of Belgrade

RESEARCH EXPERIENCE

2010 -  Research Associate, Laboratory for Human Molecular Genetics (LHMG), IMGGE
2001 - 2010 - Research Assistant, LHMG, IMGGE
1998 - 2001 - Research Trainee, Laboratory for Molecular Hematology (LMH), IMGGE

CAREER HISTORY

2016 - member of the Serbian Society for Molecular Biology
2015 - Vice President, Scientific Council of the IMGGE, UB
2014 - member of the Ethical Committee of the IMGGE, UB
2011 – member of the Scientific Council of the IMGGE, UB
2011 - member of the Serbian Genetics Society
2011 - WP Leader “Molecular genetic analysis of populations that resided in southwestern Serbia from Bronze Age to Middle Ages“ of the project “Ethnogenesis of the Serbs during the Middle Ages (until c.1250): a comparative analysis of the historic-cultural heritage, genetic material and artefacts ofmaterial culture from the aspect of analytical chemistry“ (MESTDS, 47025, 2011-2017)
2001 - Laboratory for Human Molecular Genetics, IMGGE, UB
1998 - 2001 - Laboratory for Molecular Hematology, IMGGE, UB

RESEARCH INTEREST

Studying the mtDNA diversity of the contemporary Serbian population which represents a foundation for further comparative analysis of ancient populations that inhabited the region of Serbia

Testing the bioactive components from edible mushrooms and analysis of their therapeutic potential by applying in vitro tests for cytotoxity, cell adhesion and cell migratory capacity. Analysis of the effect of bioactive compounds on expression of selected SOX genes and well-known tumor suppressors and oncogenes.

SELECTED PUBLICATIONS

  1. Davidovic S, Malyarchuk B, Aleksic J, Derenko M, Topalovic V, Litvinov A, Skonieczna K, Rogalla U, Grzybowski T, Stevanovic M, Kovacevic-Grujicic N. Mitochondrial super-haplogroup U diversity in Serbians. Ann Hum Biol. 2017 Aug;44(5):408-418. doi: 10.1080/03014460.2017.1287954. Epub 2017 Feb 19. https://www.ncbi.nlm.nih.gov/pubmed/28140657
  2.  Podolski-Renić A, Banković J, Dinić J, Ríos-Luci C, Fernandes MX, Ortega N, Kovačević-Grujičić N, Martín VS, Padrón JM, Pešić M. DTA0100, dual topoisomerase II and microtubule inhibitor, evades paclitaxel resistance in P-glycoprotein overexpressing cancer cells. Eur J Pharm Sci. 2017 Jul 15;105:159-168. doi: 10.1016/j.ejps.2017.05.011. Epub 2017 May 11. https://www.ncbi.nlm.nih.gov/pubmed/28502672
  3. Stojković DS, Kovačević-Grujičić N, Reis FS, Davidović S, Barros L, et al. Chemical composition of the mushroom Meripilus giganteus Karst. and bioactive properties of its methanolic extract. LWT - Food Science and Technology. 2017; 79:454–462.
  4. Davidovic S, Malyarchuk B, Aleksic JM, Derenko M, Topalovic V, Litvinov A, Stevanovic M, Kovacevic-Grujicic N. Mitochondrial DNA perspective of Serbian genetic diversity. Am J Phys Anthropol. 2015 Mar;156(3):449-65. doi: 10.1002/ajpa.22670. Epub 2014 Nov 24. https://www.ncbi.nlm.nih.gov/pubmed/25418795
  5. Kovacevic-Grujicic N, Mojsin M, Popovic J, Petrovic I, Topalovic V, Stevanovic M. Cyclic AMP response element binding (CREB) protein acts as a positive regulator of SOX3 gene expression in NT2/D1 cells. BMB Rep. 2014 Apr;47(4):197-202. http://www.ncbi.nlm.nih.gov/pubmed/24257117
  6. Milivojevic M, Petrovic I, Kovacevic-Grujicic N, Popovic J, Mojsin M, Stevanovic M. Construction and functional analysis of novel dominant-negative mutant of human SOX18 protein. Biochemistry (Mosc). 2013 Nov;78(11):1287-92. doi: 10.1134/S0006297913110096. http://www.ncbi.nlm.nih.gov/pubmed/24460943
  7. Mojsin M, Popovic J, Kovacevic Grujicic N, Stevanovic M. TG-interacting factor (TGIF) downregulates SOX3 gene expression in the NT2/D1 cell line. J Genet Genomics. 2012 Jan;39(1):19-27. doi: 10.1016/j.jgg.2011.11.006. Epub 2011 Dec 24. http://www.ncbi.nlm.nih.gov/pubmed/22293114
  8. Nikčević G, Kovačević-Grujičić N, Mojsin M, Krstić A, Savić T, Stevanović M. Regulation of the SOX3 gene expression by retinoid receptors. Physiol Res. 2011;60 Suppl 1:S83-91. Epub 2011 Jul 19. Review. http://www.ncbi.nlm.nih.gov/pubmed/21777018
  9. Petrovic I, Kovacevic-Grujicic N, Stevanovic M Early growth response protein 1 acts as an activator of SOX18 promoter. Exp Mol Med. 2010 Feb 28;42(2):132-42. doi: 10.3858/emm.2010.42.2.015. http://www.ncbi.nlm.nih.gov/pubmed/20054233
  10. Mojsin M, Kovacevic-Grujicic N, Krstic A, Popovic J, Milivojevic M, Stevanovic M. Comparative analysis of SOX3 protein orthologs: Expansion of homopolymeric amino acid tracts during vertebrate evolution. Biochem Genet. 2010 Aug;48(7-8):612-23. doi: 10.1007/s10528-010-9343-2. Epub 2010 May 21. http://www.ncbi.nlm.nih.gov/pubmed/20495863
  11. Petrovic I, Kovacevic-Grujicic N, Stevanovic M. ZBP-89 and Sp3 down-regulate while NF-Y up-regulates SOX18 promoter activity in HeLa cells. Mol Biol Rep. 2009 May;36(5):993-1000. doi: 10.1007/s11033-008-9272-x. Epub 2008 May 22. http://www.ncbi.nlm.nih.gov/pubmed/18496767
  12. Nikcević G, Savić T, Kovacević-Grujicić N, Stevanović M. Up-regulation of the SOX3 gene expression by retinoic acid: characterization of the novel promoter-response element and the retinoid receptors involved. J Neurochem. 2008 Dec;107(5):1206-15. doi: 10.1111/j.1471-4159.2008.05670.x. Epub 2008 Sep 11. http://www.ncbi.nlm.nih.gov/pubmed/18786169
  13. Kovacevic-Grujicic N, Mojsin M, Djurovic J, Petrovic I, Stevanovic M. Comparison of promoter regions of SOX3, SOX14 and SOX18 orthologs in mammals. DNA Seq. 2008 Jun;19(3):185-94. http://www.ncbi.nlm.nih.gov/pubmed/17852354
  14. Mojsin M, Grujicić NK, Nikcević G, Krstić A, Savić T, Stevanović M. Mapping of the RXRalpha binding elements involved in retinoic acid induced transcriptional activation of the human SOX3 gene. Neurosci Res. 2006 Dec;56(4):409-18. Epub 2006 Sep 26. http://www.ncbi.nlm.nih.gov/pubmed/17005281
  15. Kovacevic Grujicic N, Mojsin M, Krstic A, Stevanovic M. Functional characterization of the human SOX3 promoter: identification of transcription factors implicated in basal promoter activity. Gene. 2005 Jan 3;344:287-97. Epub 2004 Dec 10. http://www.ncbi.nlm.nih.gov/pubmed/15656994
  16. Nikcevic G, Kovacevic-Grujicic N, Stevanovic M. Improved transfection efficiency of cultured human cells. Cell Biol Int. 2003;27(9):735-7. http://www.ncbi.nlm.nih.gov/pubmed/12972278
  17. Skoko N, Argamante B, Grujicić NK, Tisminetzky SG, Glisin V, Ljubijankić G. Expression and characterization of human interferon-beta1 in the methylotrophic yeast Pichia pastoris. Biotechnol Appl Biochem. 2003 Dec;38(Pt 3):257-65. http://www.ncbi.nlm.nih.gov/pubmed/12911337
  18. The rat bbminy-globin promoter: nuclear protein factors and erythroid-specific induction of transcription. Pavlović S, Mitrović T, Nikcević G, Grujicić N, Lazić D, Glisin V, Popović Z. Cell Mol Life Sci. 1999 Nov 30;56(9-10):871-81. http://www.ncbi.nlm.nih.gov/pubmed/11212345

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