Jovana Jasnić Savović

Research Trainee
Laboratory for Molecular Biology (LMB)

Institute of molecular genetics and genetic engineering (IMGGE),
University of Belgrade

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mobile:           +381 65 397 66 58
Phone:           +381 11 397 66 58
Fax:                +381 11 397 58 08
E-mail: jovana.js@imgge.bg.ac.rs

EDUCATION

2016 – PhD in Biology, Faculty of Biology, University of Belgrade
2009 - PhD student, Faculty of Biology, University of Belgrade,LMB,IMGGE

RESEARCH EXPERIENCE

2015 – Research Assistant, LMB, IMGGE
2012 - Research Trainee, LMB, IMGGE
2010 - 2012 - Research Trainee, Laboratory for Human Molecular Genetics, IMGGE

RESEARCH INTEREST

Ankrd2 protein in striated muscle

Ankrd2 protein has a structural role as a component of mechanosensory complex in the sarcomere and a regulatory function in the nucleus as co-factor of transcription. It acts as signal molecule in stress triggered mechanisms and is involved in myogenic differentiation and myoblast proliferation. The aim of our study is to accurately determine the expression profile and subcellular localisation of Ankrd2 in normal conditions and under the influence of stressors using human and animal model systems. One aspect of research is determination of temporal and spatial expression profiles of Ankrd2 in zebrafish where it has not been previously studied. Our research would contribute to the understanding of pleiotropic function of Ankrd2 in skeletal muscle and heart.

SELECTED PUBLICATIONS

  1. Jasnic-Savovic J, Krause S, Savic S, Kojic A, Kovcic V, Boskovic S, Nestorovic A, Rakicevic L, Schreiber-Katz O, Vogel JG, Schoser BG, Walter MC, Valle G, Radojkovic D, Faulkner G, Kojic S. Differential expression and localization of Ankrd2 isoforms in human skeletal and cardiac muscles. Histochem Cell Biol. 2016; 146(5): 569-584. DOI:10.1007/s00418-016-1465-0
  2. Jasnic-Savovic J, Nestorovic A, Savic S, Karasek S, Vitulo N, Valle G, Faulkner G, Radojkovic D, Kojic S. Profiling of skeletal muscle Ankrd2 protein in human cardiac tissue and neonatal rat cardiomyocytes. Histochem Cell Biol. 2015; 143(6): 583-597.
  3. Jasnic-Savovic J, Klajn A, Milivojevic M, Mojsin M, Nikcevic G. Human embryonal carcinoma cells in serum-free conditions as an in vitro model system of neural differentiation. ATLA - Altern Lab Anim. 2015; 43(1): 9-18.
  4. Kojic S, Nestorovic A, Rakicevic L, Protic O, Jasnic-Savovic J, Faulkner G, Radojkovic D. Cardiac transcription factor Nkx2.5 interacts with p53 and modulates its activity. Arch Biochem Biophys. 2015; 569: 45-53.
  5. Nestorovic A, Jasnic-Savovic J, Faulkner G, Radojkovic D, Kojic S. Ankrd1-mediated signaling is supported by its interaction with Zonula Occludens-1. Arch Biol Sci. 2014; 66 (3): 1233-1242.

 

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