Research Associate
Laboratory for human molecular genetics

Institute of molecular genetics and genetic engineering (IMGGE),
University of Belgrade

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mobile:            +381 65  397 62 12                            
Phone:             +381 11  397 62 12
Fax:                +381 11  397 58 08
E-mail: jpopovic@imgge.bg.ac.rs

EDUCATION

2010 - PhD in Biology, Faculty of Biology,  University of Belgrade (UB)
(“Transcriptional regulation of human SOX14 gene expression”)
2003 - M.Sc. in Biology, Faculty of Biology, University of Belgrade
1998 - B.Sc. in Biology, Faculty of Biology, University of Belgrade

RESEARCH EXPERIENCE

2011 - Research Associate,Laboratory for Human Molecular Genetics (LHMG), IMGGE, UB
2001 - 2011 - Research Assistant, LHMG, IMGGE, UB
1998 - 2001 - Research Trainee, LHMG, IMGGE, UB

CAREER HISTORY

2016 - Jan/May- Visiting scholar, Northwestern University, Laboratory for Radiation Oncology, Chicago, USA
1998 - Laboratory for Human Molecular Genetics, IMGGE, UB

OTHER ACTIVITIES

Member of  Sebian Neurocience Society and Serbian Genetic Society

RESEARCH INTEREST

• Characterization and functional analysis of selected human SOX genes in development and cancer, with special emphasis on SOX14 gene
• Determinantion of molecular mechanism in which SOX genes are involved
• Regulation of selected human SOX genes expression
• Implementation of molecular genetic techniques in reproductive medicine
• Introducing and application of fluorescent in situ hybridization (FISH) for detection of numerical and structural chromosome aberrations in humans

SELECTED PUBLICATIONS

SOX14 activates the p53 signaling pathway and induces apoptosis in a cervical carcinoma cell line.Stanisavljevic D, Petrovic I, Vukovic V, Schwirtlich M, Gredic M, Stevanovic M, Popovic J. PLoS One. 2017.Sep 19;12(9):e0184686. https://www.ncbi.nlm.nih.gov/pubmed/28926586

Apigenin-7-O-glucoside versus apigenin: Insight into the modes of anticandidal and cytotoxic actions.Smiljkovic M, Stanisavljevic D, Stojkovic D, Petrovic I, Marjanovic Vicentic J, Popovic J, Golic Grdadolnik S, Markovic D, Sankovic-Babice S, Glamoclija J, Stevanovic M, Sokovic M. EXCLI J. 2017 May 23;16:795-807. doi: 10.17179/excli2017-300. eCollection 2017. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547395/ 

Chemical composition of the mushroom Meripilus giganteus Karst. And bioactive properties of its methanolic extract. Stojkovic D, Kovacevic-Grujicic N, Reis FS, Davidovic S, Barros L, Popovic J, Petrovic I, Pavic A, Glamoclija J, Ciric A, Stevanovic M, Ferreira I.C.F.R., Sokovic M. LWT - Food Science and Technology: (2017) 79: 454-462. http://www.sciencedirect.com/science/article/pii/S0023643817300452

SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines. Petrovic I., Milivojevic M., Popovic J., Schwirtlich M., Rankovic B., Stevanovic M. PLoS One 2015.Nov 20;10(11): e0143591. https://www.ncbi.nlm.nih.gov/pubmed/26588701

Expression analysis of SOX14 during retinoic acid induced neural differentiation of embryonal carcinoma cells and assessment of the effect of its ectopic expression on SOXB members in HeLa cells., Popovic J, Stanisavljevic D, Schwirtlich M, Klajn A, Marjanovic J, Stevanovic M. PLoS One. 2014 Mar 17;9(3):e91852. http://www.ncbi.nlm.nih.gov/pubmed/24637840

Cyclic AMP response element binding (CREB) protein acts as a positive regulator of SOX3 gene expression in NT2/D1 cells. Kovacevic-Grujicic N, Mojsin M, Popovic J, Petrovic I, Topalovic V, Stevanovic M. BMB Rep. 2014 Apr;47(4):197-202. http://www.ncbi.nlm.nih.gov/pubmed/24257117

Construction and Functional Analysis of Novel Dominant_Negative Mutant of Human SOX18 Protein. M. Milivojevic, I. Petrovic, N. Kovacevic_Grujicic, J. Popovic, M. Mojsin, and M. Stevanovic, Biochemistry (Moscow), 2013, Vol. 78, No. 11, pp. 1287_1292.  

TG-interacting factor (TGIF) downregulates SOX3 gene expression in the NT2/D1 cell line. Mojsin M, Popovic J, Kovacevic Grujicic N, Stevanovic M. J Genet Genomics. 2012 Jan;39(1):19-27.http://www.ncbi.nlm.nih.gov/pubmed/22293114

Members of the CREB/ATF and AP1 family of transcription factors are involved in the regulation of SOX18 gene expression. I.Petrović, N. Kovačević Grujičić, J. Popović, A. Krstić, M. Milivojević and M. Stevanović. Arch. Biol. Sci., Belgrade, 2011, 63 (3), 517-525. 

Comparative analysis of SOX3 protein orthologs: Expansion of homopolymeric amino acid tracts during vertebrate evolution. Mojsin M, Kovacevic-Grujicic N, Krstic A, Popovic J, Milivojevic M, Stevanovic M. Biochem Genet. 2010 Aug;48(7-8):612-23. http://www.ncbi.nlm.nih.gov/pubmed/20495863

Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression. Popovic J, Klajn A, Petrovic I, Stevanovic M. Biochim Biophys Acta. 2010 May-Jun; 1799(5-6):411-8. http://www.ncbi.nlm.nih.gov/pubmed/20074681

Remarkable evolutionary conservation of SOX14 orthologues. Popovic J, Stevanovic M. J Genet. 2009 Apr;88(1):15-24. http://www.ncbi.nlm.nih.gov/pubmed/19417540

Comparison of promoter regions of SOX3, SOX14 and SOX18 orthologs in mammals. DNA sequence. Kovacevic Grujicic N., Mojsin M., Djurovic J., Petrovic I., Stevanovic M., DNA Seq 2008. 19: 185-194 http://www.ncbi.nlm.nih.gov/pubmed/17852354

Rapid detection and purification of sequence specific DNA binding proteins using magnetic separation. Mojsin M, Djurovic J, Petrovic I, Krstic A, Drakulic D, Savic T, Stevanovic M.. J. Serb. Chem. Soc. 2006. 71(2):135-141.Structural and functional characterization of the human SOX14 promoter. Djurovic J, Stevanovic M. Biochim Biophys Acta. 2004 Oct 5;1680(1):53-9. http://www.ncbi.nlm.nih.gov/pubmed/15451172