Jasmina Nikodinović-Runić

Principal Research Fellow
Laboratory for Microbial Molecular Genetics and Ecology (LMMGE)

Institute of Molecular Genetics and Genetic Engineering (IMGGE),
University of Belgrade (UB)

Vojvode Stepe 444a, PO Box 23, 11010 Belgrade, Serbia
Mobile:  +381 65 397 60 34
Phone:  +381 11 397 60 34
Fax:      +381 11 397 58 08
E-mail: jasmina.nikodinovic@imgge.bg.ac.rs

EDUCATION

2004 - PhD in Molecular Genetics and Biochemistry, University of New South Wales, Sydney, Australia
(Thesis: Molecular genetics of amphotericin biosynthesis in Streptomyces nodosus)
2000 - B.Sc. in Molecular Genetics, University of Western Sydney, Sydney, Australia

RESEARCH EXPERIENCE

2014 - Principal Research Fellow, Laboratory for Microbial Molecular Genetics and Ecology, IMGGE, UB
2011 - 2014 - Senior Research Associate, LMMGE, IMGGE, UB
2006 - 2010 - Senior Research Fellow, Biocatalysis Group, University College Dublin, Dublin, Ireland (www.ucd.ie)
2004 - 2006 - Postdoctoral Fellow, Department of Chemistry, University of Montana, Missoula, MT, USA (www.cas.umt.edu)

ONGOING COLLABORATIONS

Dr Kevin O’Connor - University College Dublin, Ireland (www.ucd.ie)
Prof Nigel D Priestley – University of Montana, MT, USA (www.umt.edu)
Prof Evangelos Topakas - National Technical University of Athens, Athens, Greece (www.ntua.gr)
Prof Tobias Gulder – Technical University of Munich, Germany (www.tum.de)
Prof Miloš Đuran – Institute for Chemistry, Faculty of Science, University of Kragujevac, Serbia (www.kg.ac.rs)
Dr Igor Opsenica - Faculty of Chemistry, University of Belgrade, Serbia (www.chem.bg.ac.rs)
Dr Veselin Maslak – Faculty of Chemistry, University of Belgrade, Serbia (www.chem.bg.ac.rs)Dr Radivoje Prodanovic – Faculty of Chemistry, University of Belgrade, Serbia (www.chem.bg.ac.rs)
Dr Vladimir Savic – Faculty of Pharmacy, University of Belgrade, Serbia (www.pharmacy.bg.ac.rs)
Dr Niko Radulovic – Faculty of Natural Sciences and Mathematics, University of Nis, Serbia (www.pmf.ni.ac.rs)
Dr Melina Kalagasidis Krušić – Faculty of Technology, University of Belgrade, Serbia (www.tmf.bg.ac.rs)

RESEARCH INTEREST

  • MICROBIAL BIOTECHNOLOGY (BACTERIAL FERMENTATIONS, STRAIN IMPROVEMENT, Streptomyces spp., Pseudomonas spp.);
  • BIOCATALYSIS (PROTEIN EXPRESSION and DIRECTED EVOLUTION, TAUTOMERASES, LACCASSES, AMINOTRANSFERASES, BIOTRANSFORMATIONS, BIOCATALYTIC PROCESS DEVELOPMENT AND OPTIMIZATION);
  • NOVEL MATERIALS (BIOPOLYMERS, POLYHYDROXYALKANOATES, FUNCTIONALIZATION OF BIOPOLYMERS),
  • BACTERIAL BIOACTIVE SECONDARY METABOLITES (BIOPIGMENTS, ANTIFUNGAL and ANTICANCER COMPOUNDS)

SELECTED PUBLICATIONS

Bioactive molecules

Lazić J, Ajdačić V, Vojnovic S, Zlatović M, Pekmezovic M, Mogavero S, Opsenica I, Nikodinovic-Runic J. Bis-guanylhydrazones as efficient anti-Candida compounds through DNA interaction. Appl Microbiol Biotechnol. 2018;102(4):1889-1901. https://www.ncbi.nlm.nih.gov/pubmed/29330691

Warżajtis B, Glišić BĐ, Savić ND, Pavic A, Vojnovic S, Veselinović A, Nikodinovic-Runic J, Rychlewska U, Djuran MI. Mononuclear gold(III) complexes with L-histidine-containing dipeptides: tuning the structural and biological properties by variation of the N-terminal amino acid and counter anion. J Inorg Biochem. (2017); (174): 156-68. https://www.ncbi.nlm.nih.gov/pubmed/28675847

Radivojevic J, Skaro S, Senerovic L, Vasiljevic B, Guzik M, Kenny ST, Maslak V, O'Connor KE, Nikodinovic-Runic J. Polyhydroxyalkanoate-based 3-hydroxyoctanoic acid and its derivatives as a platform of bioactive compounds. Appl Microbiol Biotechnol. (2016); 100(1):161-72. http://www.ncbi.nlm.nih.gov/pubmed/26399414

Ajdačić V, Senerovic L, Vranić M, Pekmezovic M, Arsic-Arsnijevic V, Veselinovic A, Veselinovic J, Šolaja BA, Nikodinovic-Runic J, Opsenica IM. Synthesis and evaluation of thiophene-based guanylhydrazones (iminoguanidines) efficient against panel of voriconazole-resistant fungal isolates. Bioorg. Med. Chem. (2016); 24(6): 1277–91. http://www.ncbi.nlm.nih.gov/pubmed/26867487

Simic M, Paunovic N, Boric I, Randjelovic J, Vojnovic S, Nikodinovic-Runic J, Pekmezovic M, Savic V. Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies. Bioorg. Med. Chem. Lett. (2016); 26(1):235-9. http://www.ncbi.nlm.nih.gov/pubmed/26586600

Glišić BĐ, Senerovic L, Comba P, Wadepohl H, Veselinovic A, Milivojevic DR, Djuran MI, Nikodinovic-Runic J. Silver(I) complexes with phthalazine and quinazoline as effective agents against pathogenic Pseudomonas aeruginosa strains. J. Inorg. Biochem. (2016); 155:115-28. http://www.ncbi.nlm.nih.gov/pubmed/26687023

Senerovic L, Zivkovic MD, Veselinovic A, Pavic A, Djuran MI, Rajkovic S, Nikodinovic-Runic J. Synthesis and evaluation of series of diazine-bridged dinuclear platinum(II) complexes through in vitro toxicity and molecular modeling: correlation between structure and activity of Pt(II) complexes. J. Med. Chem. (2015); 58(3):1442-51. http://www.ncbi.nlm.nih.gov/pubmed/25551180

Stankovic N, Senerovic L, Ilic-Tomic T, Vasiljevic B, Nikodinovic-Runic J. Properties and applications of undecylprodigiosin and other bacterial prodigiosins. Appl. Microbiol. Biotechnol. (2014); 98, 3841-58. http://www.ncbi.nlm.nih.gov/pubmed/24562326

Nikodinovic-Runic J, Mojic M, Kang Y, Maksimovic-Ivanic D, Mijatovic S, Vasiljevic B, Stamenkovic V, Senerovic L. Undecylprodigiosin conjugated monodisperse gold nanoparticles efficiently cause apoptosis in colon cancer cells in vitro. J. Mater. Chem. B (2014); 2, 3271 - 3281. http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/c4tb00300d#!divAbstract

Stankovic, N., Senerovic, L., Bojic-Trbojevic, Z., Vuckovic, I., Vicovac, Lj., Vasiljevic, B., Nikodinovic-Runic, J..Didehydroroflamycoin (DDHR) pentaene macrolide family from Streptomyces durmitorensis MS405T: Production optimization and antimicrobial activity. J. Appl. Microbiol. (2013); 115(6):1297-306. http://www.ncbi.nlm.nih.gov/pubmed/23941529

O'Connor, S., Szwej, E., Nikodinovic-Runic, J., O'Connor, A., Byrne, A.T., Devocelle, M., O'Donovan, N., Gallagher, W.M., Babu, R., Kenny, S.T., Zinn, M., Zulian, Q.R., O'Connor, K.E. The anti-cancer activity of a cationic anti-microbial peptide derived from monomers of polyhydroxyalkanoate. Biomaterials (2013); 34, 2710–18. http://www.ncbi.nlm.nih.gov/pubmed/23343631

Biocatalysis and biopolymers

Spasic J, Mandic M, Djokic L, Nikodinovic-Runic J. Streptomyces spp. in the biocatalysis toolbox. Appl Microbiol Biotechnol. 2018;102(8):3513-3536. https://www.ncbi.nlm.nih.gov/pubmed/29502181

Almahboub SA, Narancic T, Devocelle M, Kenny ST, Palmer-Brown W, Murphy C, Nikodinovic-Runic J, O'Connor KE. Biosynthesis of 2-aminooctanoic acid and its use to terminally modify a lactoferricin B peptide derivative for improved antimicrobial activity. Appl Microbiol Biotechnol. 2018; 102(2):789-799. https://www.ncbi.nlm.nih.gov/pubmed/29177937

Narancic T, Davis R, Nikodinovic-Runic J, O' Connor KE. Recent developments in biocatalysis beyond the laboratory. Biotechnol Lett. 2015; 37(5):943-54. http://www.ncbi.nlm.nih.gov/pubmed/25555685

Djokic L, Spasic J, Jeremic S, Vasiljevic B, Prodanovic O, Prodanovic R, Nikodinovic-Runic J. Immobilization of Escherichia coli cells expressing 4-oxalocrotonate tautomerase for improved biotransformation of β-nitrostyrene. Bioprocess Biosyst. Eng. (2015); 38(12):2389-95. http://www.ncbi.nlm.nih.gov/pubmed/26410191

Guzik MW, Kenny ST, Duane GF, Casey E, Woods T, Babu RP, Nikodinovic-Runic J, Murrey M, O’Connor K. Conversion of post consumer polyethylene to the biodegradable polymer polyhydroxyalkanoate. Appl. Microbiol. Biotechnol. (2014); 98, 4223-32. http://www.ncbi.nlm.nih.gov/pubmed/24413975

Molloy, S., Nikodinovic-Runic, J., Martin, L.B., Hartmann, H., Solano, F., Decker, H., O'Connor, K.E. Engineering of a bacterial tyrosinase for improved catalytic efficiency towards D-tyrosine using random and site directed mutagenesis approaches. Biotechnol. Bioeng. (2013); 110, 1849–57. http://www.ncbi.nlm.nih.gov/pubmed/23381872

Narancic, T., Radivojevic, J., Jovanovic, P., Francuski, D., Bigovic, M., Maslak, V., Savic, V., Vasiljevic, B., O'Connor, K.E., Nikodinovic-Runic, J. Highly efficient Michael-type addition of acetaldehyde to b-nitrostyrenes by whole resting cells of Escherichia coli expressing 4-oxalocrotonate tautomerase. Biores. Technol. (2013); 142, 462–68. http://www.ncbi.nlm.nih.gov/pubmed/23759430

Nikodinovic-Runic, J., Guzik, M., Kenny, S.T., Babu, R., Werker, A., O'Connor, K.E. Carbon-rich wastes as feedstocks for biodegradable polymer (polyhydroxyalkanoate) production using bacteria. Adv. Appl. Microbiol. (2013); 84, 139-200. http://www.ncbi.nlm.nih.gov/pubmed/23763760

Nikodinovic-Runic, J., Casey, E., Duane, G.F., Mitic, D., Hume, A.R., Kenny, S.T., O'Connor, K.E. Process analysis of the conversion of styrene to biomass and medium chain length polyhydroxyalkanoate in a two-phase bioreactor. Biotechnol. Bioeng. (2011); 108, 2447-55. http://www.ncbi.nlm.nih.gov/pubmed/21520026 

Please publish modules in offcanvas position.