Danijela Drakulić

Research Associate

Institute of molecular genetics and genetic engineering (IMGGE),
University of Belgrade

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mobile: +381 65 397 62 12                          
Phone:  +381 11 397 62 12
Fax:     +381 11 397 58 08
E-mail: danijeladrakulic@imgge.bg.ac.rs

EDUCATION

2011 - PhD in Biological Sciences, Faculty of Biology (FB), UB (Analysis of effects of SOX2 overexpression on pluripotency, proliferation and neural differentation of embryonal carcinoma NT2/D1 cells)
2005 - M.Sc. in Biology, FB, UB
2000 - B.Sc. in Molecular biology and physiology, FB, University of Belgrade

RESEARCH EXPERIENCE

2012 - Research Associate, Laboratory for Human Molecular Genetics (LHMG), IMGGE
2005 - 2012 - Research Assistant, LHMG, IMGGE
2002 - 2005 - Research Trainee, LHMG, IMGGE

CAREER HISTORY

2017 - Management Committee member of COST Action: CA16210 - Maximising Impact of research in NeuroDevelopmental DisorderS (MINDDS)
2017 – member of Serbian Society for Molecular Biology
2017 – member of Serbian Genetic Society
2013 – 2016 WP leader (WP3 Reinforcement of human resources) of project FP7-REGPOT-2012-2013-1 “Strengthening the Research Potential of IMGGE through Reinforcement of Biomedical Science of Rare Diseases in Serbia – en route for innovation”- SERBORDISinn
2012 - Lecturer on Faculty of Biology, University of Belgrade on Doctoral degree program (Methodology in Molecular Biology)
2009 - Wellcome Trust Advanced Course: Genetic Manipulation of ES cells, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, 20 October- 8 November
2007 - Preimplantation Genetic Diagnosis Workshop, UCL centre, London, United Kingdom, 16-20 April
2004 - University of Nottingham, Queen’s Medical Centre, Nottingham, United Kingdom, September 2004.- learning technique RNA-RNA in situ hybridization
2003 - Theoretical and Practical Course: Molecular Cytogenetics using fluorescent in situ hybridisation techniques, Sfax, Тunisia, 4-12 April

RESEARCH INTEREST

Analysis the effects of modulation of SOXB1 expression on pluripotency, proliferation, migration, neural differentiation and cell death of embryonal carcinoma and cancer cell lines

Introducing and application of fluorescent in situ hybridization (FISH) for detection of numerical and structural chromosome aberrations in humans

SELECTED PUBLICATIONS

Cuturilo G, Drakulic D, Jovanovic I, Ilic S, Kalanj J, Vulicevic I, Raus M, Skoric D, Mijovic M, Medjo B, Rsovac S, Stevanovic M. The Impact of 22q11.2 Microdeletion on Cardiac Surgery Postoperative Outcome. Pediatr Cardiol. 2017 38(8):1680-5. https://www.ncbi.nlm.nih.gov/pubmed/28940032 

Marjanović Vićentić J, Schwirtlich M, Kovačević- Grujičić N, Stevanović M, Drakulić D. All-trans retinoic acid influences viability, migration and adhesion of U251 glioblastoma cells. Arch Biol Sci. 2017 69(4):699-706. http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641700016M 

Cuturilo G, Drakulic D, Jovanovic I, Krstic A, Djukic M, Skoric D, Mijovic M, Stefanovic I, Milivojevic M, Stevanovic M. Improving the Diagnosis of Children with 22q11.2 Deletion Syndrome: A Single-center Experience from Serbia. Indian Pediatr. 2016 53(9):786-9. https://www.ncbi.nlm.nih.gov/pubmed/27771646 

Rakonjac M, Cuturilo G, Stevanovic M, Jelicic L, Subotic M, Jovanovic I, Drakulic D. Differences in speech and language abilities between children with 22q11.2 deletion syndrome and children with phenotypic features of 22q11.2 deletion syndrome but without microdeletion. Res Dev Disabil. 2016 55:322-9.
https://www.ncbi.nlm.nih.gov/pubmed/27235769  

Rakonjac M, Cuturilo G, Stevanovic M, Jovanovic I, Dobrijevic Jelicic LJ, Mijovic M, Drakulic D. Speech and language abilities of children with the familial form of 22q11.2 deletion syndrome. GENETIKA-BELGRADE. 2016 48(1):57-72. http://www.dgsgenetika.org.rs/abstrakti/vol48no1rad6.pdf 

Mojsin M, Topalovic V, Vicentic JM, Schwirtlich M, Stanisavljevic D, Drakulic D, Stevanovic M. Crosstalk between SOXB1 proteins and WNT/β-catenin signaling in NT2/D1 cells. Histochem Cell Biol. 2015 144(5):429-41. https://www.ncbi.nlm.nih.gov/pubmed/26239426 

Drakulic D, Marjanovic Vicentic J, Schwirtlich M, Tosic J, Krstic A, Klajn A, Stevanovic M. The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1. An Acad Bras Cienc. 2015 87(1):389-404. https://www.ncbi.nlm.nih.gov/pubmed/25761220 

Klajn A, Drakulic D, Tosic M, Pavkovic Z, Schwirtlich M, Stevanovic M. SOX2 overexpression affects neural differentiation of human pluripotent NT2/D1 cells. Biochemistry (Mosc). 2014 79(11):1172-82. https://www.ncbi.nlm.nih.gov/pubmed/25540002 

Cuturilo G, Drakulic D, Krstic A, Gradinac M, Ilisic T, Parezanovic V, Milivojevic M, Stevanovic M, Jovanovic I. The role of modern imaging techniques in the diagnosis of malposition of the branch pulmonary arteries and possible association with microdeletion 22q11.2. Cardiol Young. 2013 23(2):181-8. https://www.ncbi.nlm.nih.gov/pubmed/22717372 

Drakulic D, Krstic A, Stevanovic M. Establishment and initial characterization of SOX2-overexpressing NT2/D1 cell clones. Genet Mol Res. 2012 11(2):1385-400. https://www.ncbi.nlm.nih.gov/pubmed/22653585 

Cuturilo G, Menten B, Krstic A, Drakulic D, Jovanovic I, Parezanovic V, Stevanovic M. 4q34.1-q35.2 deletion in a boy with phenotype resembling 22q11.2 deletion syndrome. Eur J Pediatr. 2011 170(11):1465-70. https://www.ncbi.nlm.nih.gov/pubmed/21833498 

Djordjević VA, Jovanović JV, Pavković-Lučić SB, Drakulić DD, Djurović MM, Gotić MD. Cytogenetic findings in Serbian patients with Turner's syndrome stigmata. Genet Mol Res. 2010 9(4):2213-21. https://www.ncbi.nlm.nih.gov/pubmed/21064029 

Jovicić D, Milacić S, Vukov TD, Rakić B, Stevanović M, Drakulić D, Rakić R, Bukvić N. Detection of premature segregation of centromeres in persons exposed to ionizing radiation. Health Phys. 2010 98(5):717-27. https://www.ncbi.nlm.nih.gov/pubmed/20386201   Milivojević M, Nikčević G, Kovačević-Grujičić N, Krstić A, Mojsin M, Drakulić D, Stevanović M. Involvement of ubiquitous and TALE transcription factors, as well as liganded RXR in the regulation of human SOX2 gene expression in NT2/D1 embryonal carcinoma cell line. Arch Biol Sci. 2010 62:199-210. 

Djordjević V, Dencić-Fekete M, Jovanović J, Drakulić D, Stevanović M, Janković G, Gotić M. Pattern of trisomy 1q in hematological malignancies: a single institution experience. Cancer Genet Cytogenet. 2008 186(1):12-8. https://www.ncbi.nlm.nih.gov/pubmed/18786437   Cuturilo G, Drakulic D, Stevanovic M, Jovanovic I, Djukic M, Miletic-Grkovic S, Atanaskovic-Markovic M. A rare association of interrupted aortic arch type C and microdeletion 22q11.2. Eur J Pediatr. 2008 167(10):1195-8. https://www.ncbi.nlm.nih.gov/pubmed/18040716 

Drakulić D, Nikčević G, Djordjević V, Stevanović M. Generation of a whole chromosome painting probe from monochromosomal hybrid cells by the Alu-polymerase chain reaction. Arch Biol Sci. 2007 59:89-95. 

Mojsin M, Djurovic J, Petrovic I, Krstic A, Drakulic D, Savic T, Stevanovic M. Rapid detection and purification of sequence specific DNA binding proteins using magnetic separation. Journal of the Serbian Chemical Society. 2006 71:135-141. 

Miljkovic Dj, Samardzic T, Drakulic D, Stosic-Grujicic S, Trajkovic V. Immunosuppressants leflunomide and mycophenolic acid inhibit fibroblast IL-6 production by distinct mechanisms. Cytokine. 2002 19(4):181-6. https://www.ncbi.nlm.nih.gov/pubmed/12297111 

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