Isidora Petrović

Research Associate

Institute of molecular genetics and genetic engineering (IMGGE),
University of Belgrade

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mobile: +381 65 3976212                          
Phone: +381 11 3976212
Fax:     +381 11 3975808
E-mail: isidorapetrovic@imgge.bg.ac.rs

EDUCATION

2012 - PhD in Biological sciences, Faculty of Biology (FB), University of Belgrade (UB)
(“Transcriptional regulation of the human SOX18 gene expression”)
2005 - M.Sc. in Biological sciences, FB, UB
2000 - B.Sc. in Molecular Biology and Physiology, FB, UB

RESEARCH EXPERIENCE

2013 - Research Associate Laboratory for human molecular genetics, IMGGE
2005 - 2013 - Research Assistant Laboratory for human molecular genetics,IMGGE
2001 - 2005 - Research Trainee Laboratory for human molecular genetics,IMGGE

RESEARCH INTEREST

The major research interest is to study the role of SOX genes in cancer development and methastasis. Our aim is to search, within SOX gene family, for possible new diagnostic and prognostic markers and potential anticancer-drug targets. We are investigating the crosstalk between SOX genes and Hedgehog (Hh) signaling pathway in cancer cell lines, and possibilities of potential inhibition of tumor growth by applying inhibitors that target both Hh pathway activity and SOX expression. In addition we are in search for new potential anticancer agents within various natural or synthesized compounds. 

SELECTED PUBLICATIONS

Smiljkovic M, Stanisavljevic D, Stojkovic D, Petrovic I, Marjanovic Vicentic J, Popovic J, Golic Grdadolnik S, Markovic D, Sankovic-Babice S, Glamoclija J, Stevanovic M, Sokovic M.Apigenin-7-O-glucoside versus apigenin: Insight into the modes of anticandidal and cytotoxic actions. EXCLI J. 2017 May 23;16:795-807. doi: 10.17179/excli2017-300. eCollection 2017.
https://www.ncbi.nlm.nih.gov/pubmed/28827996 

Dejan S. Stojkovic , Natasa Kovacevic-Grujici, Filipa S. Reis, Slobodan Davidovic , Lillian Barrosc, Jelena Popovi, Isidora Petrovic, Aleksandar Pavic, Jasmina Glamoclija, Ana Ciric, Milena Stevanovic, Isabel C.F.R. Ferreira, Marina Sokovic . Chemical composition of the mushroom Meripilus giganteus Karst. and bioactive properties of its methanolic extract, LWT - Food Science and TechnologyVolume 79, June 2017, Pages 454-462 http://dx.doi.org/10.1016/j.lwt.2017.01.045

Stanisavljevic D, Petrovic I, Vukovic V, Schwirtlich M, Gredic M, Stevanovic M, Popovic J. SOX14 activates the p53 signaling pathway and induces apoptosis in a cervical carcinoma cell line. PLoS One. 2017 Sep 19;12(9):e0184686. doi: 10.1371/journal.pone.0184686. eCollection 2017. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604970/

Kovacevic-Grujicic N, Mojsin M, Popovic J, Petrovic I, Topalovic V, Stevanovic M. Cyclic AMP response element binding (CREB) protein acts as a positive regulator of SOX3 gene expression in NT2/D1 cells. BMB Rep. 2014 Apr;47(4):197-202. http://www.ncbi.nlm.nih.gov/pubmed/24257117

Milivojevic M, Petrovic I, Kovacevic-Grujicic N, Popovic J, Mojsin M, Stevanovic M. Construction and functional analysis of novel dominant-negative mutant of human SOX18 protein. Biochemistry (Mosc). 2013 Nov;78(11):1287-92. doi: 10.1134/S0006297913110096. http://www.ncbi.nlm.nih.gov/pubmed/24460943

Petrovic I, Kovacevic-Grujicic N, Stevanovic M Early growth response protein 1 acts as an activator of SOX18 promoter. Exp Mol Med. 2010 Feb 28;42(2):132-42. doi: 10.3858/emm.2010.42.2.015. http://www.ncbi.nlm.nih.gov/pubmed/20054233

Popović J., Klajn A., Petrović I., Stevanović M. Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression. 2010. Biochim Biophys Acta- Gene Reg Mech 1799(5-6):411-418. doi: 10.1016/j.bbagrm.2010.01.002. Epub 2010 Jan 13. http://www.ncbi.nlm.nih.gov/pubmed/20074681

Petrovic I, Kovacevic-Grujicic N, Stevanovic M. ZBP-89 and Sp3 down-regulate while NF-Y up-regulates SOX18 promoter activity in HeLa cells. Mol Biol Rep. 2009 May;36(5):993-1000. doi: 10.1007/s11033-008-9272-x. Epub 2008 May 22. http://www.ncbi.nlm.nih.gov/pubmed/18496767

Kovacevic-Grujicic N, Mojsin M, Djurovic J, Petrovic I, Stevanovic M. Comparison of promoter regions of SOX3, SOX14 and SOX18 orthologs in mammals. DNA Seq. 2008 Jun;19(3):185-94. http://www.ncbi.nlm.nih.gov/pubmed/17852354

Petrovic I, Milivojevic M, Popovic J, Schwirtlich M, Rankovic B, Stevanovic M. SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines. PLoS One. 2015 Nov 20;10(11):e0143591.

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