Principal Research Fellow
Laboratory for Molecular Biology (LMB)

Institute of Molecular Genetics and Genetic Engineering (IMGGE),
University of Belgrade (UB)

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mobile:           +381 65 397 66 58                          
Phone:           +381 11 397 66 58
Fax:               +381 11 397 58 08
E-mail: dada@imgge.bg.ac.rs

EDUCATION

1997 - PhD in Molecular Biology, Faculty of Biology (FB), UB (Thesis: Prenatal diagnostics of cystic fibrosis by DNA analysis)
1986 - M.Sc. in Molecular Biology, FB, UB
1982 - B.Sc. in Molecular Biology, PMF, UB

RESEARCH EXPERIENCE

2007 - Principal Research Fellow, LMB, IMGGE
2001 - 2007 - Senior research associatek, LMB, IMGGE
2000 - 2005 - Postdoctoral fellow, Department of Human Genetics,KUL, Belgium
1998 - 2001 - Research associate, LMB, IMGGE, UB
1994 - 1997 - Research Assistant, LMB, IMGGE
1984 - 1994 - Research Trainee, Institut za zdravstvenu zaštitu majke i deteta, RS

CAREER HISTORY

2010 - Head of  of LMB, IMGGE, UB
2007 - Coordinator of courses and lecturer on PhD programme „Molecular Biology“, FB, UB
2005 - Principal investigator,LMB, IMGGE, UB 
2000-2005 - Department  for human genetics, KUL, Belgium
1994-2000 - LMB, IMGGE, UB
1984-1994 - Laboratory for medical genetics, Mother and child Health Institute. Belgrade, Serbia      

RESEARCH INTEREST

Human molecular genetics, medical genetics, modifier genes in phenotype modulation, gene expression, structural and functional characterization of noncoding DNA,biomarkers, personalized medicine, pharmacogenetics, predictive and preventive noninvasive diagnostics,public health

SELECTED PUBLICATIONS

Petrovic-Stanojevic N, Topic A, Nikolic A, Stankovic M, Dopudja-Pantic V, Milenkovic B, Radojkovic D. Polymorphisms of Beta2-Adrenergic Receptor Gene in Serbian Asthmatic Adults: Effects on Response to Beta-Agonists. Mol Diagn Ther. 2014 Jul 30 PMID: 2507450, http://www.ncbi.nlm.nih.gov/pubmed/25074500

Ljujic M, Divac Rankov A, Kojic S, Miranda E, Radojkovic D. Functional analysis of novel alpha-1 antitrypsin variants G320R and V321F. Mol Biol Rep. 2014 Sep;41(9):6133-41. http://www.ncbi.nlm.nih.gov/pubmed/24969485

 Nikolic A, Radlovic N, Dinic J, Milosevic K, Radojkovic D.Clinical presentation of mild cystic fibrosis in a Serbian patient homozygous for the CFTR mutation c.1393-1G>A.J Cyst Fibros. 2014 Jan;13(1):111-3. http://www.ncbi.nlm.nih.gov/pubmed/23933162

Djordjevic V, Kovac M, Miljic P, Murata M, Takagi A, Pruner I, Francuski D, Kojima T, Radojkovic D,A novel prothrombin mutation in two families with prominent thrombophilia - the first cases of antithrombin resistance in a Caucasian population. J Thromb Haemost. 2013 Oct;11(10):1936 http://www.ncbi.nlm.nih.gov/pubmed/23927452

Mendizabal I, Lao O, Marigorta UM, Wollstein A, Gusmão L, Ferak V, Ioana M, Jordanova A, Kaneva R, Kouvatsi A, Kučinskas V, Makukh H, Metspalu A, Netea MG, de Pablo R, Pamjav H, Radojkovic D, Rolleston SJ, Sertic J, Macek M Jr, Comas D, Kayser M. Reconstructing the population history of European Romani from genome-wide data. Curr Biol. 18; 22(24):2342-9. http://www.ncbi.nlm.nih.gov/pubmed/23219723

Topic A, Francuski D, Markovic B, Stankovic M, Dobrivojevic S, Drca S, Radojkovic D  Gender-related reference intervals of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine determined by liquid chromatography-tandem mass spectrometry in Serbian population. Clin Biochem. 2013,46 (4-5):321-6 http://www.ncbi.nlm.nih.gov/pubmed/23261837

Kovac MK, Rakicevic LB, Kusic-Tisma JS, Radojkovic DP. Pharmacogenetic tests could be helpful in predicting of VKA maintenance dose in elderly patients at treatment initiation.J Thromb Thrombolysis 2013, 35 (1):90-4. http://www.ncbi.nlm.nih.gov/pubmed/22763922

Topic A, Stankovic M, Divac-Rankov A, Petrovic-Stanojevic N, Mitic-Milikic M, Nagorni-Obradovic L, Radojkovic D. Alpha-1-antitrypsin deficiency in Serbian adults with lung diseases. Genet Test Mol Biomarkers 2012, 16(11):1282-6  http://www.ncbi.nlm.nih.gov/pubmed/22971141

Stanke F, Becker T, Kumar V, Hedtfeld S, Becker C, Cuppens H, Tamm S, Yarden J, Laabs U, Siebert B, Fernandez L, Macek M Jr, Radojkovic D, Ballmann M, Greipel J, Cassiman JJ, Wienker TF, Tümmler B. Genes that determine immunology and inflammation modify the basic defect of impaired ion conductance in cystic fibrosis epithelia. J Med Genet. 2011,48(1):24-31 http://www.ncbi.nlm.nih.gov/pubmed/20837493

11.       Nikolic A, Kojic S, Knezevic S, Krivokapic Z, Ristanovic M, Radojkovic D Structural and functional analysis of SMAD4 gene promoter in malignant pancreatic and colorectal tissues: detection of two novel polymorphic nucleotide repeats.Cancer Epidemiol 2011, 35(3):265-71 http://www.ncbi.nlm.nih.gov/pubmed/21036691

Bombieri C, Claustres M, De Boeck K, Derichs N, Dodge J, Girodon E, Sermet I, Schwarz M, Tzetis M, Wilschanski M, Bareil C, Bilton D, Castellani C, Cuppens H, Cutting GR, Drevínek P, Farrell P, Elborn JS, Jarvi K, Kerem B, Kerem E, Knowles M, Macek M Jr, Munck A, Radojkovic D, Seia M, Sheppard DN, Southern KW, Stuhrmann M, Tullis E, Zielenski J, Pignatti PF, Ferec CRecommendations for the classification of diseases as CFTR-related disorders  J Cyst Fibros.2011, 10 Suppl 2:S86-102. http://www.ncbi.nlm.nih.gov/pubmed/21658649

 Kojic S, Radojkovic D, Faulkner G  Muscle ankyrin repeat proteins: their role in striated muscle function in health and disease.Crit Rev Clin Lab Sci. 2011,48(5-6):269-94. http://www.ncbi.nlm.nih.gov/pubmed/22185618

Castellani C, Cuppens H, Macek M Jr, Cassiman JJ, Kerem E, Durie P, Tullis E, Assael BM, Bombieri C, Brown A, Casals T, Claustres M, Cutting GR, Dequeker E, Dodge J, Doull I, Farrell P, Ferec C, Girodon E, Johannesson M, Kerem B, Knowles M, Munck A, Pignatti PF, Radojkovic D, Rizzotti P, Schwarz M, Stuhrmann M, Tzetis M, Zielenski J, Elborn JS  Consensus on the use and interpretation of cystic fibrosis mutation analysis in clinical practice. J Cyst Fibros. 2008,7(3):179-96. http://www.ncbi.nlm.nih.gov/pubmed/18456578

Stanke F, Becker T, Cuppens H, Kumar V, Cassiman JJ, Jansen S, Radojkovic D, Siebert B, Yarden J, Ussery DW, Wienker TF, Tummler B. The TNFalpha receptor TNFRSF1A and genes encoding the amiloride-sensitive sodium channel ENaC as modulators in cystic fibrosis. Hum Genet. 2006,119 (3):331-43 http://www.ncbi.nlm.nih.gov/pubmed/16463024

Yarden J, Radojkovic D, De Boeck K, Macek Jr M, Zemkova D, Vavrova V, Vlietinck R, Cassiman J-J, Cuppens H Association of tumour necrosis factor alpha variants with the CF pulmonary phenotype Thorax 2005, 60(4): 320–325 http://www.ncbi.nlm.nih.gov/pubmed/15790988

Yarden J, Radojkovic D, De Boeck K, Macek Jr M, Zemkova D, Vavrova V, Viletinck R, Cassiman J-J, Cuppens H. Polymorphisms in the mannose binding lectin gene affect the cystic fibrosis pulmonary phenotype J Med Genet. 2004, 41: 629-633  http://www.ncbi.nlm.nih.gov/pubmed/15286159

Miković D., Lj.Rakićević,  M.Kovač,  D.Radojkovic. The Incidence of Factor V Leiden in Yugoslav Thrombophilic Patients and Its Relationship to the Laboratory Diagnosis of APC Resistance. Thrombosis and hemostasis 2000, 84, 823-824  http://www.ncbi.nlm.nih.gov/pubmed/11057877                                                                                       

Kušić J., Radojkovic D., Cuppens H., Jaspers M., Tomić J, Savić A.  Identification of a novel mutation 525delT in exon 4 of CFTR gene in patient with cystic fibrosis, Human Mutation, 1999, 14/4,357 http://www.ncbi.nlm.nih.gov/pubmed/10502789

Brukner Dabovic,B., D.Radojkovic, P.Minic, J.Savic and A.Savic Frequency of the  F508 deletion and G551D, R553X and G542X mutations in Yugoslav CF patients , Hum.Genet. 1992, 88, 699-700 http://www.ncbi.nlm.nih.gov/pubmed/1551678