Nataša Tošić

Senior Research Associate
Laboratory for molecular biomedicine

Institute of Molecular Genetics and Genetic Engineering (IMGGE),
University of Belgrade

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mobile:           +381 65  39 76 445                         
Phone:           +381 11  39 76 445
Fax:               +381 11 397 58 08
E-mail: natasa.tosic@imgge.bg.ac.rs

EDUCATION

2010 - PhD in Molecular Genetics and Genetic Engineering, Faculty of Biology (FB), UB (The interaction of genetic markers of proliferation, differentiation and apoptosis in acute leukemia)
2002 - M.Sc. in Molecular Genetics and Genetic Engineering, FB, UB
1998 - B.Sc. in Molecular Biology and Physisology, FB, University of Belgrade

RESEARCH EXPERIENCE

2016 - Senior Research Associate, IMGGE, UB
2011 - 2016 - Research Associate, IMGGE, UB
2003 - 2011 - Research Assistant, IMGGE, UB
1999 - 2000 - Research Trainee, Vinca Institute, Belgrade

CAREER HISTORY

2004 - researcher at the Laboratory of Molecular Biomedicine, IMGGE, UB
2000 - 2003 - Volunteer at the Laboratory for Immunology, Institute for Blood Transfusion of Serbia, Belgrade
1999 - 2000 - Researcher at the Laboratory for antioxidant enzymes, Vinca Institute,

RESEARCH INTEREST

Hematologic malignancies, mainly acute and chronic leukemia. The genetic basis of the disease and the abberation in the process of differentiation, proliferation and apoptosis. Molecular markers significant for the diagnosis of disease, monitoring and treatment of hematologic malignancies.

SELECTED PUBLICATIONS

A gene expression profile associated with relapse of cytogenetically normal acute myeloid leukemia is enriched for leukemia stem cell genes. Hackl H, Steinleitner K, Lind K, Hofer S, Tosic N, Pavlovic S, Suvajdzic N, Sill H, Wieser R. Leuk Lymphoma. 2014 Aug 18:1-3.

Complex patterns of chromosome 11 aberrations in myeloid malignancies target CBL, MLL, DDB1 and LMO2. Klampfl T, Milosevic JD, Puda A, Schönegger A, Bagienski K, Berg T, Harutyunyan AS, Gisslinger B, Rumi E, Malcovati L, Pietra D, Elena C, Della Porta MG, Pieri L, Guglielmelli P, Bock C, Doubek M, Dvorakova D, Suvajdzic N, Tomin D, Tosic N, Racil Z, Steurer M, Pavlovic S, Vannucchi AM, Cazzola M, Gisslinger H, Kralovics R. PLoS One. 2013 Oct 16;8(10):e77819.

Expression of Bcl2L12 in chronic lymphocytic leukemia patients: association with clinical and molecular prognostic markers.Karan-Djurasevic T, Palibrk V, Zukic B, Spasovski V, Glumac I, Colovic M, Colovic N, Jurisic V, Scorilas A, Pavlovic S, Tosic N. Med Oncol. 2013 Mar;30(1):405

The influence of novel transcriptional regulatory element in intron 14 on the expression of Janus kinase 2 gene in myeloproliferative neoplasms. Spasovski V, Tosic N, Nikcevic G, Stojiljkovic M, Zukic B, Radmilovic M, Karan-Djurasevic T, Srzentic S, Colovic M, Pavlovic S. J Appl Genet. 2013 Feb;54(1):21-6.

Prognostic impact of NPM1 mutations in Serbian adult patients with acute myeloid leukemia. Kuzmanovic M, Tosic N, Colovic N, Karan-Djurasevic T, Spasovski V, Radmilovic M, Nikcevic G, Suvajdzic-Vukovic N, Tomin D, Vidovic A, Virijevic M, Pavlovic S, Colovic M. Acta Haematol. 2012;128(4):203-12.

Clinical significance of genetic aberrations in secondary acute myeloid leukemia. Milosevic JD, Puda A, Malcovati L, Berg T, Hofbauer M, Stukalov A, Klampfl T, Harutyunyan AS, Gisslinger H, Gisslinger B, Burjanivova T, Rumi E, Pietra D, Elena C, Vannucchi AM, Doubek M, Dvorakova D, Robesova B, Wieser R, Koller E, Suvajdzic N, Tomin D, Tosic N, Colinge J, Racil Z, Steurer M, Pavlovic S, Cazzola M, Kralovics R. Am J Hematol. 2012 Nov;87(11):1010-6

Overexpression of the novel member of the BCL2 gene family, BCL2L12, is associated with the disease outcome in patients with acute myeloid leukemia. Thomadaki H, Floros KV, Pavlovic S, Tosic N, Gourgiotis D, Colovic M, Scorilas A. Clin Biochem. 2012 Nov;45(16-17):1362-7.

Reversal of FLT3 mutational status and sustained expression of NPM1 mutation in paired presentation, and relapse samples in a patient with acute myeloid leukemia. Radojkovic M, Tosic N, Colovic N, Ristic S, Pavlovic S, Colovic M. Ann Clin Lab Sci. 2012 Spring;42(2):186-90

Mutational status and gene repertoire of IGHV-IGHD-IGHJ rearrangements in Serbian patients with chronic lymphocytic leukemia. Karan-Djurasevic T, Palibrk V, Kostic T, Spasovski V, Nikcevic G, Srzentic S, Colovic M, Colovic N, Vidovic A, Antic D, Mihaljevic B, Pavlovic S, Tosic N. Clin Lymphoma Myeloma Leuk. 2012 Aug;12(4):252-60.

Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies. Puda A, Milosevic JD, Berg T, Klampfl T, Harutyunyan AS, Gisslinger B, Rumi E, Pietra D, Malcovati L, Elena C, Doubek M, Steurer M, Tosic N, Pavlovic S, Guglielmelli P, Pieri L, Vannucchi AM, Gisslinger H, Cazzola M, Kralovics R. Am J Hematol. 2012 Mar;87(3):245-50.

Central nervous system relapse in CD56+, FLT3/ITD+ promyelocytic leukemia. Colovic N, Tomin D, Vidovic A, Tosic N, Atkinson HD, Colovic MD. Med Oncol. 2012 Mar;29(1):260-2

Acute myeloid leukemia with NUP98-HOXC13 fusion and FLT3 internal tandem duplication mutation: case report and literature review. Tosić N, Stojiljković M, Colović N, Colović M, Pavlović S. Cancer Genet Cytogenet. 2009 Sep;193(2):98-103.

Incidence of FLT3 and nucleophosmin gene mutations in childhood acute myeloid leukemia: Serbian experience and the review of the literature. Krstovski N, Tosic N, Janic D, Dokmanovic L, Kuzmanovic M, Spasovski V, Pavlovic S. Med Oncol. 2010 Sep;27(3):640-5.

Clinical features of the most common fusion genes in childhood acute lymphoblastic leukemia. Lazic J, Tosic N, Dokmanovic L, Krstovski N, Rodic P, Pavlovic S, Janic D. Med Oncol. 2010 Jun;27(2):449-53.

Polymorphisms of tumor-necrosis factor-alpha - 308 and lymphotoxin-alpha + 250: possible modulation of susceptibility to apoptosis in chronic lymphocytic leukemia and non-Hodgkin lymphoma mononuclear cells. Jevtovic-Stoimenov T, Kocic G, Pavlovic D, Macukanovic-Golubovic L, Marjanovic G, Djordjevic V, Tosić N, Pavlović S. Leuk Lymphoma. 2008 Nov;49(11):2163-9.

Importance of early detection and follow-up of FLT3 mutations in patients with acute myeloid leukemia. Colovic N, Tosic N, Aveic S, Djuric M, Milic N, Bumbasirevic V, Colovic M, Pavlovic S. Ann Hematol. 2007 Oct;86(10):741-7.

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