Sonja Pavlović

Principal Research Fellow

Institute of Molecular Genetics and Genetic Engineering (IMGGE),
University of Belgrade

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mobile:  +381 65 397 64 45                          
Phone:  +381 11 397 64 45
Fax:      +381 11 397 58 08
E-mail: sonya@sezampro.rs

EDUCATION

2001 - PhD in Molecular Genetics and Genetic Engineering, Faculty of Biology (FB), University of Belgrade (UB) (Molecular genetics of thalassemia syndromes: correlation between molecular pathology and phenotype)
1996 - M.Sc. in Molecular Genetics and Genetic Engineering, FB, UB
1992 - B.Sc. in Molecular Biology and Physiology, FB, University of Belgrade

RESEARCH EXPERIENCE

2011 - Principal Reseach Fellow Laboratory for Molecular Hematology (LMH) and Laboratory for Molecular Biomedicine (LMB), IMGGE
2007 - 2011 - Senior Research AssociateLMH, IMGGE
2002 - 2007 - Research Associate LMH, IMGGE
1996 - 2002 - Research Assistant LMH, IMGGE
1993 - 1996 - Research Trainee, LMH, IMGGE

CAREER HISTORY

2015 - Head of  LMH, IMGGE 
2013 - 2015 -
Principal Investigator LMB, IMGGE
2001- 2013 - Head of  LMH, IMGGE
2000 - Lecturer on Faculty of Biology, UB
2009 - Leader of Science Promotion and Popularization Program “Short Course of DNAlogy” 
2011 - Serbian National Coordinator of PGENI (Pharmacogenetics for Every Nation Initiative)
2011 - Member of the Council of the Institutes University of Belgrade
2012 - Member of the Academic Council of Medical Sciencies University of Belgrade
2005 - Guest scientist. Centro Ricerca M. Tettamanti, Universita di Milano-Biccoca, H. San Gerardo, Monza, Italy
1999 - Guest scientist. Istituto di Clinica e Biologià dell’Età Evolutiva Università degli Studi, Cagliari, Italy
1993 - 2001 - Staff member, LMH, IMGGE
1983 - 1994 - Piano teacher in the Music School

RESEARCH INTEREST

Molecular genetics of rare diseases, thalassemia (regulation of transcription of beta-globin genes, modifier genes), hematological malignancies (molecular markers of childhood and adult acute and chronic myeloid and lymphoid leukemias, lymphomas and multiple myelomas), molecular basis of metabolic diseases (phenylketonuria), molecular genetics of inflammatory bowel diseases (Crohn’s disease, ulcerative colitis, celiac disease), pulmonary diseases (tuberculosis, idiopathic pulmonary fibrosis, hereditary pulmonary hypertension, sarcoidosis), rheumatological diseases (systemic sclerosis, myositis, rheumatoid arthritis), orthopedic diseases, inflammation, autoimmunity, genotype-phenotype correlation, population genetics, molecular diagnosis, stem cell and gene therapy and pharmacogenomics.

SELECTED PUBLICATIONS

Paschou P, Drineas P, Yannaki E, Razou A, Kanaki K, Tsetsos F, Padmanabhuni SS, Michalodimitrakis M, Renda MC, Pavlovic S, Anagnostopoulos A, Stamatoyannopoulos JA, Kidd KK, Stamatoyannopoulos G. Maritime route of colonization of Europe. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9211-6 http://www.ncbi.nlm.nih.gov/pubmed/24927591

Stanković B, Radlović N, Leković Z, Ristić D, Radlović V, Nikčević G, Kotur N, Vučićević K, Kostić T, Pavlović S, Zukic B.HLA genotyping in pediatric celiac disease patients.Bosn J Basic Med Sci. 2014 Aug 16;14(3):171-6.http://www.ncbi.nlm.nih.gov/pubmed/25172978

Srzentić S, Spasovski V, Spasovski D, Zivković Z, Matanović D, Bascarević Z, Supić ZT, Stojiljković M, Karan-Djurasević T, Stanković B, Pavlović S, Nikcević G, Vukasinović Z.Association of gene variants in TLR4 and IL-6 genes with Perthes disease.Srp Arh Celok Lek. 2014 Jul-Aug;142(7-8):450-6.http://www.ncbi.nlm.nih.gov/pubmed/25233690

Karan-Djurasevic T, Palibrk V, Zukic B, Spasovski V, Glumac I, Colovic M, Colovic N, Jurisic V, Scorilas A, Pavlovic S, Tosic N. Expression of Bcl2L12 in chronic lymphocytic leukemia patients: association with clinical and molecular prognostic markers. Med Oncol 2013, 30(1):405. http://www.ncbi.nlm.nih.gov/pubmed/23292833

Radmilovic M, Zukic B, Stojiljkovic M, Bartsakoulia M, Stankovic B, Kotur N, Dokmanovic L, Georgitsi M, Patrinos G, Pavlovic S. Functional analysis of a novel KLF1 gene promoter variation associated with hereditary persistence of fetal hemoglobin. Annals of Hematology 2013, 92(1):53-8.http://www.ncbi.nlm.nih.gov/pubmed/23161389

Spasovski V, Tosic N, Nikcevic G, Stojiljkovic M, Zukic B, Radmilovic M, Karan – Djurasevic T, Srzentic S, Colovic M, Pavlovic S. The influence of novel transcriptional regulatory element in intron 14 on expression of Janus kinase 2 gene in myeloproliferative neoplasms. J Appl Genet 2013, 54(1):21-6.http://www.ncbi.nlm.nih.gov/pubmed/23188718

Rodic P, Pavlovic S, Kostic T, Suvajdzic Vukovic N, Djordjevic M, Sumarac Z, Dajak M, Bonaci Nikolic B, Janic D. Gammopathy and B lymphocyte clonality in patients with Gaucher type I disease. Blood Cells Mol Dis. 2013 50: 222-225.http://www.ncbi.nlm.nih.gov/pubmed/23265739

Jančić I, Arsenović-Ranin N, Sefik-Bukilica M, Zivojinović S, Damjanov N, Spasovski V, Srzentić S, Stanković B, Pavlović S. -174G/C interleukin-6 gene promoter polymorphism predicts therapeutic response to etanercept in rheumatoid arthritis. Rheumatol Int. 2013 Jun;33(6):1481-6. http://www.ncbi.nlm.nih.gov/pubmed/23233117

Klampfl T, Milosevic JD, Puda A, Schönegger A, Bagienski K, Berg T, Harutyunyan AS, Gisslinger B, Rumi E, Malcovati L, Pietra D, Elena C, Della Porta MG, Pieri L, Guglielmelli P, Bock C, Doubek M, Dvorakova D, Suvajdzic N, Tomin D, Tosic N, Racil Z, Steurer M, Pavlovic S, Vannucchi AM, Cazzola M, Gisslinger H, Kralovics R. Complex Patterns of Chromosome 11 Aberrations in Myeloid Malignancies Target CBL, MLL, DDB1 and LMO2. PLoS One. 2013 Oct 16;8(10):e77819. http://www.ncbi.nlm.nih.gov/pubmed/24147083

Milosevic JD, Puda A, Malcovati L, Berg T, Hofbauer M, Stukalov A, Klampfl T, Harutyunyan AS, Gisslinger H, Gisslinger B, Burjanivova T, Rumi E, Pietra D, Elena C, Vannucchi AM, Doubek M, Dvorakova D, Robesova B, Wieser R, Koller E, Suvajdzic N, Tomin D, Tosic N, Colinge J, Racil Z, Steurer M, Pavlovic S, Cazzola M, Kralovics R. Clinical significance of genetic aberrations in secondary acute myeloid leukemia. Am J Hematol. 2012, 87(11):1010-6.http://www.ncbi.nlm.nih.gov/pubmed/22887079

Giardine B, Borg J, Higgs D, Peterson K, Philipsen S, Maglott D, Singleton B, Anstee D, Basak AN, Clark B, Costa F, Faustino P, Fedosyuk H, Felice A, Francina A, Galanello R, Gallivan M, Georgitsi M, Gibbons R, Giordano P, Harteveld C, Hoyer J, Jarvis M, Joly P, Kanavakis E, Kollia P, Menzel S, Miller W, Moradkhani K, Old J, Papachatzopoulou A, Papadakis M, Papadopoulos P, Pavlovic S, Perseu L, Radmilovic M, Riemer C, Satta S, Schrijver I, Stojiljkovic M, Thein SL, Traeger-Synodinos J, Tully R, Wada T, Waye J, Wiemann C, Zukic B, Chui D, Wajcman H, Hardison R, Patrinos P. Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach. Nat Genet 2011: 43(4): 295-301. http://www.ncbi.nlm.nih.gov/pubmed/21423179

Zukic B, Radmilovic M, Stojiljkovic M, Tosic N, Pourfarzad F, Dokmanovic L, Janic D, Colovic N, Philipsen S, Patrinos G, Pavlovic S Functional analysis of the role of the TPMTgene promoter VNTR polymorphism ingene transcription. Pharmacogenomics. 2010:11 (4), 547-557.http://www.ncbi.nlm.nih.gov/pubmed/20350137

Stojiljkovic M, Zukic B, Tosic N, Karan-Djurasevic T, Spasovski V, Nikcevic G, Pavlovic S. Novel transcriptional regulatory element in the phenylalanine hydroxylase gene intron. Mol. Genet. Metab. 2010: 101 (1), 81-83.http://www.ncbi.nlm.nih.gov/pubmed/20599406

Tosic N, Stojiljkovic M, Colovic N, Colovic M, Pavlovic S. Acute myeloid leukemia with NUP98-HOXC13 fusion and FLT3 internal tandem duplication: case report and literature review. Cancer Genet. Cytogenet. 2009: 193, 98-103.http://www.ncbi.nlm.nih.gov/pubmed/19665070

Pavlovic S. TPMT gene polymorphisms: on the doorstep of personalized medicine.Indian J Med Res. 2009 May;129(5):478-80.http://www.ncbi.nlm.nih.gov/pubmed/19675373

Colovic N, Tosic N, Aveic S, Djuric M, Milic N, Bumbasirevic V, Colovic M, Pavlovic S.) Importance of early detection and follow-up of FLT3 mutations in patients with acute myeloid leukemia. Annals of Hematology 2007: 86, 741-747. http://www.ncbi.nlm.nih.gov/pubmed/17579862

Dokmanovic L, Urosevic J, Janic D, Jovanovic N, Petrucev B, Tosic N, Pavlovic S. Analysis of thiopurine S-methyltransferase Polymorhism in the Population of Serbia and Montenegro and Mercaptopurine Therapy Tolerance in Childhood Acute Lymphoblastic Leukemia. Ther. Drug. Monit. 2006: 28, 800-806.http://www.ncbi.nlm.nih.gov/pubmed/17164697

Stojiljkovic M, Jovanovic J, Djordjevic M, Grkovic S, Cvorkov Drazic M, Petrucev B, Tosic N, Karan Djurasevic T, Stojanov L, Pavlovic S. Molecular and phenotypic characteristics of patients with phenylketonuria in Serbia and Montenegro. Clin Genet. 2006 Aug;70(2):151-5. http://www.ncbi.nlm.nih.gov/pubmed/16879198

Pavlovic S, Urosevic J, Poznanic J, Perisic Lj, Petrucev B, Tosic N, Krivokapic-Dokmanovic L, Janic D, Cvorkov-Drazic M, Bunjevacki G. (2005) Molecular basis and origin of thalassemia syndromes in Serbia. Acta Haematologica 113, 175-180.http://www.ncbi.nlm.nih.gov/pubmed/15870487

Pavlovic S, Mitrovic T, Nikcevic G, Grujicic N, Lazic D, Glisin V, Popovic Z. (1999) The rat βbminy-globin promoter: nuclear protein factors and erythroid-specific induction of transcription. Cell. Mol. Life Sci. 56, 871-881.http://www.ncbi.nlm.nih.gov/pubmed/11212345

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