Gordana Nikčević

Principal Research Fellow
Laboratory for Molecular Biomedicine

Institute of Molecular Genetics and Genetic Engineering (IMGGE),
University of Belgrade

V. Stepe 444a, P.Fah 23, 11010 Belgrade, Serbia
Mobile: +381 64 208 49 06                          
Phone: +381 11 397 64 45
Fax:     +381 11 397 58 08
E-mail:  gordnik@imgge.bg.ac.rs

EDUCATION

1998 - PhD in Biology, Faculty of Biology (FB), University of Belgrade (UB) (title of the thesis: "The effect of expression of the catalytic domain of myosin light chain kinase on the contractile properties of non-muscle cells")
1988 - M.Sc. in Biology, FB, UB
1984 - B.Sc. in Biology, FB, UB

RESEARCH EXPERIENCE

2006 - Senior Research Associate, IMGGE, UB
2000 - 2006 - Research Associate,IMGGE, UB
1993 - 2000 - Visiting Scientist, University of Illinois at Chicago, USA
1988 - 1993 - Research Assistant, IMGGE
1986 - 1988 - Research Trainee, Genetic Engineering Center, Belgrade

CAREER HISTORY

2014 - Lecturer on Faculty of Biology (FB), UB, at PhD course:
           Personalized Medicine and Pharmacogenomics
2008 - Lecturer on FB, UB, at PhD course:Methodological approaches in molecular biology
2007 - Lecturer on FB, UB, at PhD course:Molecular biology of the gene
2001 - 2006 - Deputy Director of the IMGGE, UB

OTHER ACTIVITIES

2013 - Chairman of the IMGGE, UB Scientific Board
2010 - Deputy Chairman of the IMGGE, UB Board

RESEARCH INTEREST

Studying the molecular mechanisms involved in the regulation of expression of selected eukaryotic genes. The examination of molecular basis of various rare diseases, analysis of genetic polymorphisms important for optimisation of drug therapy in the treatment of inflammatory diseases. The use of animal mesenchymal stem cells from the adipose tissue in regenerative medicine and tissue engineering. Studying the approaches to increase therapeutic capacity of these cells by genetic modifications - by expression of specific transgeneswhose products could be beneficial for remodeling of bone and cartilage tissues.

SELECTED PUBLICATIONS

  1. Stanković B, Radlović N, Leković Z, Ristić D, Radlović V, Nikčević G, Kotur N, Vučićević K, Kostić T, Pavlović S, Zukic B. HLAgenotyping inpediatric celiacdiseasepatients. Bosn J Basic Med Sci 2014: 14, 171-176. http://www.ncbi.nlm.nih.gov/pubmed/25172978
  2. Srzentić S, Spasovski V, Spasovski D, Zivković Z, Matanović D, Bascarević Z, Supić ZT, Stojiljković M, Karan-Djurasević T, Stanković B, Pavlović S, Nikcević G, Vukasinović Z. Association of gene variants in TLR4 and IL-6 genes with Perthes disease. Srp Arh Celok Lek 2014: 142, 450-456. http://www.ncbi.nlm.nih.gov/pubmed/25233690
  3. SpasovskiV, TosicN, NikcevicG, StojiljkovicM, ZukicB, RadmilovicM, Karan – DjurasevicT, SrzenticS, ColovicM, PavlovicS. The influence of novel transcriptional regulatory element in intron 14 on expression of Janus kinase 2 gene in myeloproliferative neoplasms. J Appl Genet 2013: 54, 21-26. http://www.ncbi.nlm.nih.gov/pubmed/23188718
  4. Kotur N, Stankovic B, Kassela K, Georgitsi M, Vicha A, Dokmanovic L, Janic D, Krstovski N, Klaassen K, Radmilovic M, Stojiljkovic M, Nikcevic G, Simeonidis A, Sivolapenko G, Pavlovic S, Patrinos GP, Zukic B. Six-mercaptopurine influences TPMT gene transcription in a TPMT gene promoter variable number of tandem repeats-dependent manner. Pharmacogenomics 2012: 13, 283-295. http://www.ncbi.nlm.nih.gov/pubmed/22304581
  5. Nikčević G., Kovačević-Grujičić N.,  Mojsin M., Krstić A., Savić T., and Stevanović M. Regulation of the SOX3 Gene Expression by Retinoid Receptors. Physiol Res 2011: 60, S83-S91. http://www.ncbi.nlm.nih.gov/pubmed/21777018
  6. Stojiljkovic M., Zukic B., Tosic N., Karan-Djurasevic T., Spasovski V., Nikcevic G. and Pavlovic S. Noveltranscriptionalregulatoryelementinthephenylalaninehydroxylasegeneintron 8. Mol Genet Metab 2010: 101, 81-83. http://www.ncbi.nlm.nih.gov/pubmed/20599406
  7. Nikčević G, Savić T, Kovačević-Grujičić N. and Stevanović M, Up-regulation of the SOX3 gene expression by retinoic acid: characterization of the novel promoter-response element and the retinoid receptors involved. J Neurochem 2008: 107, 1206-1215. http://www.ncbi.nlm.nih.gov/pubmed/18786169
  8. Mojsin M, Grujicic KN, Nikcevic G, Krstic A, Savic T, Stevanovic M. Mapping of the RXRalpha binding elements involved in retinoic acid induced transcriptional activation of the human SOX3 gene. Neurosci Res 2006: 56, 409-418. http://www.ncbi.nlm.nih.gov/pubmed/17005281
  9. Nikčević, G., Kovačević-Grujičić, N. and Stevanović, M. Improved transfection efficiency of cultured human cells. Cell Biol Int  2003: 27, 735-737. http://www.ncbi.nlm.nih.gov/pubmed/12972278
  10. Nikčević, G., Perhonen, M., Boateng, S. and Russell, B. Translation is regulated via the 3’ untranslated region of a-myosin heavy chain mRNA by calcium but not by its localization. J Muscle Res Cell M  2000: 21, 599-607. http://www.ncbi.nlm.nih.gov/pubmed/11206137
  11. Nikčević, G., Heidkamp, M., Perhonen, M. and Russell, B. Mechanical activity in heart regulates translation of a-myosin heavy chain mRNA but not its localization. Am J Physiol-Heart Circ 1999: 276, H2013-H2019. http://www.ncbi.nlm.nih.gov/pubmed/10362682
  12. Hecht, G.A., Pestić, L., Nikčević, G., Koutsouris, A., Tripuraneni, J., Lorimer, D., Nowak, G., Guerriero, V., Elson, E. and de Lanerolle, P. Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability. Am J Physiol-Cell Physiol 1996: 271, C1678‑C1684. http://www.ncbi.nlm.nih.gov/pubmed/8944652
  13. Obara, K., Nikčević, G., Pestić, L., Nowak, G., Guerriero, V., Paul, R.J., Elson, E.L. and de Lanerolle, P. Fibroblast contractility without an increase in basal myosin light chain phosphorylation in wild type cells and cells expressing the catalytic domain of myosin light chain kinase. J Biol Chem 1995: 270, 18734‑18737. http://www.ncbi.nlm.nih.gov/pubmed/7642521
  14. Marjanović, J., Savković, S., Nikčević, G., Glišin, V., Ivanović, Z., Milenković, P. and Popović, Z.  The disbalance of a‑ and b‑globins in anemic Belgrade rat red blood cells.Biochem Bioph Res Co 1994: 201, 115‑122. http://www.ncbi.nlm.nih.gov/pubmed/8198563
  15. Knežić, Z., Nikčević, G., Marjanović, J., Glišin, V. and Popović, Z.  Constitutive interferon expression from retroviral vector. Antivir Res 1993: 22, 215‑221. http://www.ncbi.nlm.nih.gov/pubmed/8279813
 

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